Pub Date : 2025-01-01Epub Date: 2024-11-17DOI: 10.1016/j.addr.2024.115473
Boaz Barak, Paolo Decuzzi
{"title":"Drug delivery systems for treating neurodevelopmental disorders.","authors":"Boaz Barak, Paolo Decuzzi","doi":"10.1016/j.addr.2024.115473","DOIUrl":"10.1016/j.addr.2024.115473","url":null,"abstract":"","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":" ","pages":"115473"},"PeriodicalIF":15.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-09-14DOI: 10.1016/j.addr.2024.115455
Qixin Chen, Jiajie Diao
{"title":"Editorial: Super-resolution imaging of sub-cellular dynamics of drug molecules.","authors":"Qixin Chen, Jiajie Diao","doi":"10.1016/j.addr.2024.115455","DOIUrl":"10.1016/j.addr.2024.115455","url":null,"abstract":"","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":" ","pages":"115455"},"PeriodicalIF":15.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-19DOI: 10.1016/j.addr.2024.115504
Auel Tobias, Mentrup Aaron Felix Christofer, Oldfield Lee Roy, Seidlitz Anne
Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if individualization is desired. In this review article the authors systematically researched literature published during the last 5 years (2019 – spring 2024) on the topic of 3D printed dosage forms. Besides all kinds of oral dosage forms ranging from tablets and capsules to films, pellets, etc., numerous reports were also identified on parenteral and cutaneous dosage forms and also rectal, vaginal, dental, intravesical, and ophthalmic preparations. In total, more than 500 publications were identified and grouped according to the site of administration, and an overview of the manuscripts is presented here. Furthermore, selected publications are described and discussed in more detail. The review highlights the very different approaches that are currently used in order to develop 3D printed dosage forms but also addresses remaining challenges.
三维（3D）打印，也称为增材制造，被认为是改变许多行业游戏规则的技术，也被认为在医药制造中具有潜在的用例，尤其是在需要个性化的情况下。在这篇综述文章中，作者系统地研究了过去 5 年（2019 年至 2024 年春）内发表的有关 3D 打印剂型主题的文献。除了从片剂、胶囊到薄膜、颗粒等各种口服剂型外，还发现了大量关于肠外和皮肤剂型以及直肠、阴道、牙科、膀胱内和眼科制剂的报道。总共确定了 500 多篇出版物，并根据给药部位进行了分组，在此对这些手稿进行了概述。此外，还对部分出版物进行了详细描述和讨论。综述重点介绍了目前用于开发 3D 打印剂型的各种不同方法，同时也探讨了仍然存在的挑战。
{"title":"3D printing of pharmaceutical dosage forms: Recent advances and applications","authors":"Auel Tobias, Mentrup Aaron Felix Christofer, Oldfield Lee Roy, Seidlitz Anne","doi":"10.1016/j.addr.2024.115504","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115504","url":null,"abstract":"Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if individualization is desired. In this review article the authors systematically researched literature published during the last 5 years (2019 – spring 2024) on the topic of 3D printed dosage forms. Besides all kinds of oral dosage forms ranging from tablets and capsules to films, pellets, etc., numerous reports were also identified on parenteral and cutaneous dosage forms and also rectal, vaginal, dental, intravesical, and ophthalmic preparations. In total, more than 500 publications were identified and grouped according to the site of administration, and an overview of the manuscripts is presented here. Furthermore, selected publications are described and discussed in more detail. The review highlights the very different approaches that are currently used in order to develop 3D printed dosage forms but also addresses remaining challenges.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"201 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-19DOI: 10.1016/j.addr.2024.115505
Nicolas Burns, Arjun Rajesh, Avinash Manjula-Basavanna, Anna Duraj-Thatte
In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications. Herein, microbes are genetically engineered to produce 1) extrudable bioink and 2) life-like functionalities such as self-regeneration, self-healing, self-regulation, biosynthesis, biosensing, biosignaling, biosequestration, etc. We also discuss some of the promising applications of 3D extrusion printed microbial inks, such as 1) drugs and probiotics delivery, 2) metabolite production, 3) tissue engineering, 4) bioremediation, 5) biosensors and bioelectronics, 6) biominerals and biocomposites, and 7) infectious disease modeling. Finally, we describe some of the current challenges of microbial inks that needs to be addressed in the coming years, to make a greater impact in health science and technology and many other fields.
{"title":"3D extrusion bioprinting of microbial inks for biomedical applications","authors":"Nicolas Burns, Arjun Rajesh, Avinash Manjula-Basavanna, Anna Duraj-Thatte","doi":"10.1016/j.addr.2024.115505","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115505","url":null,"abstract":"In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications. Herein, microbes are genetically engineered to produce 1) extrudable bioink and 2) life-like functionalities such as self-regeneration, self-healing, self-regulation, biosynthesis, biosensing, biosignaling, biosequestration, etc. We also discuss some of the promising applications of 3D extrusion printed microbial inks, such as 1) drugs and probiotics delivery, 2) metabolite production, 3) tissue engineering, 4) bioremediation, 5) biosensors and bioelectronics, 6) biominerals and biocomposites, and 7) infectious disease modeling. Finally, we describe some of the current challenges of microbial inks that needs to be addressed in the coming years, to make a greater impact in health science and technology and many other fields.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"87 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-19DOI: 10.1016/j.addr.2024.115503
Yuan Xiong, Mahesh N. Samtani, Daniele Ouellet
The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches. It is now an indispensable component throughout the whole continuum of drug discovery, development, regulatory review, and approval. Today, applications of pharmacometrics are common in designing better trials and accelerating evidence-based decisions. Newly emerging technologies, especially those from data and computer sciences, are being integrated with existing computational tools used in the pharmaceutical industry at a remarkably fast pace. The new challenges faced by the pharmacometrics community are not what or how to contribute, but which optimal MIDD strategy should be adopted to maximize its value in the decision-making process. While we are embracing new innovative approaches and tools, this article discusses how a variety of existing modeling tools, with differentiated advantages and focus, can work in concert to inform drug development.
{"title":"Application of pharmacometrics in drug development","authors":"Yuan Xiong, Mahesh N. Samtani, Daniele Ouellet","doi":"10.1016/j.addr.2024.115503","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115503","url":null,"abstract":"The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches. It is now an indispensable component throughout the whole continuum of drug discovery, development, regulatory review, and approval. Today, applications of pharmacometrics are common in designing better trials and accelerating evidence-based decisions. Newly emerging technologies, especially those from data and computer sciences, are being integrated with existing computational tools used in the pharmaceutical industry at a remarkably fast pace. The new challenges faced by the pharmacometrics community are not what or how to contribute, but which optimal MIDD strategy should be adopted to maximize its value in the decision-making process. While we are embracing new innovative approaches and tools, this article discusses how a variety of existing modeling tools, with differentiated advantages and focus, can work in concert to inform drug development.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"7 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-13DOI: 10.1016/j.addr.2024.115483
Zhewen Luo, Haoran Chen, Xinyuan Bi, Jian Ye
Monitoring the kinetic changes of drugs and metabolites plays a crucial role in fundamental research, preclinical and clinical application. Raman spectroscopy (RS) is regarded as a fingerprinting technique that can reflect molecular structures but limited in applications due to poor sensitivity. Surface-enhanced Raman spectroscopy (SERS) significantly amplifies the detection sensitivity by plasmonic substrates, facilitating the identification and quantification of small molecules in biological samples, such as serum, urine, and living cells. This review will focus on advances in how SERS has been utilized to monitor the dynamic processes of small molecule drugs and metabolites in recent years. We first provide readers with a comprehensive overview of the mechanism and practical considerations of SERS, including enhancement theory, substrate design, sample pretreatment, molecule–substrate interactions and spectral analysis. Then we describe the latest advances in SERS for the detection and analysis of metabolites and drugs in cells, dynamic monitoring of drug in various biological matrices, and metabolic profiling for health assessment in biological fluids. We believe that high-performance SERS substrates, standardized technical regulations, and artificial intelligence spectral analysis will boost sensitive, accurate, reproducible, and universal molecular detection in the future. We hoped this review could inspire researchers working in related fields to better understand and utilize SERS for the analytical detection of drugs and metabolites.
{"title":"Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy","authors":"Zhewen Luo, Haoran Chen, Xinyuan Bi, Jian Ye","doi":"10.1016/j.addr.2024.115483","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115483","url":null,"abstract":"Monitoring the kinetic changes of drugs and metabolites plays a crucial role in fundamental research, preclinical and clinical application. Raman spectroscopy (RS) is regarded as a fingerprinting technique that can reflect molecular structures but limited in applications due to poor sensitivity. Surface-enhanced Raman spectroscopy (SERS) significantly amplifies the detection sensitivity by plasmonic substrates, facilitating the identification and quantification of small molecules in biological samples, such as serum, urine, and living cells. This review will focus on advances in how SERS has been utilized to monitor the dynamic processes of small molecule drugs and metabolites in recent years. We first provide readers with a comprehensive overview of the mechanism and practical considerations of SERS, including enhancement theory, substrate design, sample pretreatment, molecule–substrate interactions and spectral analysis. Then we describe the latest advances in SERS for the detection and analysis of metabolites and drugs in cells, dynamic monitoring of drug in various biological matrices, and metabolic profiling for health assessment in biological fluids. We believe that high-performance SERS substrates, standardized technical regulations, and artificial intelligence spectral analysis will boost sensitive, accurate, reproducible, and universal molecular detection in the future. We hoped this review could inspire researchers working in related fields to better understand and utilize SERS for the analytical detection of drugs and metabolites.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"1 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a new application of the recently developed technique, Optical Coherence Elastography (OCE) to quantitatively visualize kinetics of osmotic strains due to diffusive penetration of various osmotically active solutions into biological tissues. The magnitude of osmotic strains may range from fractions of one per cent to tens per cent. The visualized spatio-tempotal dynamics of the strains reflect the rates of osmotic dehydration and diffusional penetration of the active solute, which can be controlled by concentration of the solution components. Main features of the OCE-visualized diffusion-front dynamics well agree with Fick’s theory yielding diffusivity coefficients consistent with the literature data. The OCE technique may be used to study diffusion of a broad variety of osmotically-active substances − drugs, cosmetic agents, preservative solutions, so-called optical clearing agents enhancing the depth of optical visualization, etc. The corresponding experimental examples, some results of theoretical interpretations and numerical simulations are given.
{"title":"Visualizing kinetics of diffusional penetration in tissues using OCT-based strain imaging","authors":"Y.M. Alexandrovskaya, A.A. Sovetsky, E.M. Kasianenko, A.L. Matveyev, L.A. Matveev, O.I. Baum, V.Y. Zaitsev","doi":"10.1016/j.addr.2024.115484","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115484","url":null,"abstract":"We report a new application of the recently developed technique, Optical Coherence Elastography (OCE) to quantitatively visualize kinetics of osmotic strains due to diffusive penetration of various osmotically active solutions into biological tissues. The magnitude of osmotic strains may range from fractions of one per cent to tens per cent. The visualized spatio-tempotal dynamics of the strains reflect the rates of osmotic dehydration and diffusional penetration of the active solute, which can be controlled by concentration of the solution components. Main features of the OCE-visualized diffusion-front dynamics well agree with Fick’s theory yielding diffusivity coefficients consistent with the literature data. The OCE technique may be used to study diffusion of a broad variety of osmotically-active substances − drugs, cosmetic agents, preservative solutions, so-called optical clearing agents enhancing the depth of optical visualization, etc. The corresponding experimental examples, some results of theoretical interpretations and numerical simulations are given.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"19 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, the conventional criterion of “one-size-fits-all” is not qualified for each individual patient, requiring precision medicine for enhanced therapeutic effects. Besides, drug screening is a high-cost and time-consuming process which requires innovative approaches to facilitate drug development rate. Benefiting from consistent technical advances in 3D bioprinting techniques, droplet-based 3D bioprinting techniques have been broadly utilized in pharmaceutics due to the noncontact printing mechanism and precise control on the deposition position of droplets. More specifically, cell-free/cell-laden bioinks which are deposited for the fabrication of drug carriers/3D tissue constructs have been broadly utilized for precise drug delivery and high throughput drug screening, respectively. This review summarizes the mechanism of various droplet-based 3D bioprinting techniques and the most up-to-date applications in drug delivery and screening and discusses the potential improvements of droplet-based 3D bioprinting techniques from both technical and material aspects. Through technical innovations, materials development, and the assistance from artificial intelligence, the formation process of drug carriers will be more stable and accurately controlled guaranteeing precise drug delivery. Meanwhile, the shape fidelity and uniformity of the printed tissue models will be significantly improved ensuring drug screening efficiency and efficacy.
{"title":"Droplet-based 3D bioprinting for drug delivery and screening","authors":"Heqi Xu, Shaokun Zhang, Kaidong Song, Huayong Yang, Jun Yin, Yong Huang","doi":"10.1016/j.addr.2024.115486","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115486","url":null,"abstract":"Recently, the conventional criterion of “one-size-fits-all” is not qualified for each individual patient, requiring precision medicine for enhanced therapeutic effects. Besides, drug screening is a high-cost and time-consuming process which requires innovative approaches to facilitate drug development rate. Benefiting from consistent technical advances in 3D bioprinting techniques, droplet-based 3D bioprinting techniques have been broadly utilized in pharmaceutics due to the noncontact printing mechanism and precise control on the deposition position of droplets. More specifically, cell-free/cell-laden bioinks which are deposited for the fabrication of drug carriers/3D tissue constructs have been broadly utilized for precise drug delivery and high throughput drug screening, respectively. This review summarizes the mechanism of various droplet-based 3D bioprinting techniques and the most up-to-date applications in drug delivery and screening and discusses the potential improvements of droplet-based 3D bioprinting techniques from both technical and material aspects. Through technical innovations, materials development, and the assistance from artificial intelligence, the formation process of drug carriers will be more stable and accurately controlled guaranteeing precise drug delivery. Meanwhile, the shape fidelity and uniformity of the printed tissue models will be significantly improved ensuring drug screening efficiency and efficacy.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"78 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-07DOI: 10.1016/j.addr.2024.115485
Corrado Mazzaglia, Yan Yan Shery Huang, Jacqueline D. Shields
Cancer progression is significantly influenced by the complex interactions within the tumor microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors from the circulation and surrounding lymphoid tissues in an attempt to control their spread. However, they often fail in this task. Current in vivo and in vitro preclinical models struggle to fully capture these intricate interactions affecting our ability to understand immune evasion and predict drugs behaviour in the clinic. To address this challenge, biofabrication and particularly 3D bioprinting has emerged as a promising tool for modeling both tumors and the immune system. Its ability to incorporate multiple cell types into 3D matrices, enable tissue compartmentalization with high spatial accuracy, and integrate vasculature makes it a valuable approach. Nevertheless, limited research has focused on capturing the complex tumor-immune interplay in vitro. This review highlights the composition and significance of the TME, the architecture and function of lymphoid tissues, and innovative approaches to modeling their interactions in vitro, while proposing the concept of an extended TME.
{"title":"Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication","authors":"Corrado Mazzaglia, Yan Yan Shery Huang, Jacqueline D. Shields","doi":"10.1016/j.addr.2024.115485","DOIUrl":"https://doi.org/10.1016/j.addr.2024.115485","url":null,"abstract":"Cancer progression is significantly influenced by the complex interactions within the tumor microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors from the circulation and surrounding lymphoid tissues in an attempt to control their spread. However, they often fail in this task. Current <em>in vivo</em> and <em>in vitro</em> preclinical models struggle to fully capture these intricate interactions affecting our ability to understand immune evasion and predict drugs behaviour in the clinic. To address this challenge, biofabrication and particularly 3D bioprinting has emerged as a promising tool for modeling both tumors and the immune system. Its ability to incorporate multiple cell types into 3D matrices, enable tissue compartmentalization with high spatial accuracy, and integrate vasculature makes it a valuable approach. Nevertheless, limited research has focused on capturing the complex tumor-immune interplay <em>in vitro</em>. This review highlights the composition and significance of the TME, the architecture and function of lymphoid tissues, and innovative approaches to modeling their interactions <em>in vitro</em>, while proposing the concept of an extended TME.","PeriodicalId":7254,"journal":{"name":"Advanced drug delivery reviews","volume":"1 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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