Porous Mg–Zn–Ca scaffolds for bone repair: a study on microstructure, mechanical properties and in vitro degradation behavior

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-03-25 DOI:10.1007/s10856-023-06754-y

Lei Huo, Qiang Li, Linlin Jiang, Huiqin Jiang, Jianping Zhao, Kangjian Yang, Qiangsheng Dong, Yi Shao, Chenglin Chu, Feng Xue, Jing Bai

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Abstract

Biodegradable porous Mg scaffolds are a promising approach to bone repair. In this work, 3D-spherical porous Mg–1.5Zn–0.2Ca (wt.%) scaffolds were prepared by vacuum infiltration casting technology, and MgF₂ and fluorapatite coatings were designed to control the degradation behavior of Mg-based scaffolds. The results showed that the pores in Mg-based scaffolds were composed of the main spherical pores (450–600 μm) and interconnected pores (150–200 μm), and the porosity was up to 74.97%. Mg-based porous scaffolds exhibited sufficient mechanical properties with a compressive yield strength of about 4.04 MPa and elastic modulus of appropriately 0.23 GPa. Besides, both MgF₂ coating and fluorapatite coating could effectively improve the corrosion resistance of porous Mg-based scaffolds. In conclusion, this research would provide data support and theoretical guidance for the application of biodegradable porous Mg-based scaffolds in bone tissue engineering.

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用于骨修复的多孔镁锌钙支架：关于微观结构、机械性能和体外降解行为的研究

生物可降解多孔镁支架是一种很有前景的骨修复方法。该研究采用真空渗透铸造技术制备了三维球形多孔镁-1.5锌-0.2钙（重量百分比）支架，并设计了MgF2和氟磷灰石涂层来控制镁基支架的降解行为。结果表明，镁基多孔支架的孔隙由主要的球形孔隙（450-600 μm）和相互连接的孔隙（150-200 μm）组成，孔隙率高达 74.97%。镁基多孔支架具有足够的机械性能，抗压屈服强度约为 4.04 兆帕，弹性模量约为 0.23 千兆帕。此外，MgF2 涂层和氟磷灰石涂层都能有效提高多孔镁基支架的耐腐蚀性。总之，该研究将为生物可降解多孔镁基支架在骨组织工程中的应用提供数据支持和理论指导。

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.