A Pilot Study of Urine Oxytocin as an Objective Biomarker for Chronic Pain

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-22 DOI:10.1177/09727531231224141

Daisuke Ono, T. Matsusaki, Yoshikazu Matsuoka, R. Kaku, Hiroshi Morimatsu

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Abstract

Background: Measuring pain objectively or quantitatively is difficult. Since urine oxytocin (OXT) concentration has been reported to be potentially associated with chronic pain. Purpose: We conducted a pilot study to evaluate the relationship between changes in numerical rating scale (NRS) score following nerve block and urine OXT concentration in patients with chronic pain. Methods: We investigated 19 chronic pain patients who were admitted to our hospital for nerve intervention. NRS score and urine OXT concentration were assessed before and after the nerve block. Results: NRS scores were 7 [6, 9] and 2 [1, 4] (median [interquartile range]) before and after the treatment intervention, respectively. Urinary OXT levels were 523 [293, 743] and 531 [308, 887] pg/mL (median [interquartile range]) before and after the treatment, respectively. We compared the group with greater improvement in NRS after the treatment intervention and those with less improvement. The group with greater improvement in NRS after the treatment intervention showed a greater increase in OXT level. However, baseline urine OXT concentrations were highly variable in patients with chronic pain and the changes in urinary OXT concentrations were also variable. Conclusion: Based on this pilot study, the utility of urine OXT concentration as an objective biomarker of chronic pain needs further investigation.

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尿催产素作为慢性疼痛客观生物标志物的试点研究

背景：对疼痛进行客观或定量的测量非常困难。据报道，尿液催产素（OXT）浓度可能与慢性疼痛有关。目的：我们进行了一项试验性研究，以评估慢性疼痛患者神经阻滞后的数字评分量表（NRS）评分变化与尿液催产素浓度之间的关系。方法：我们对 19 名慢性疼痛患者进行了调查：我们调查了 19 名在我院接受神经介入治疗的慢性疼痛患者。评估神经阻滞前后的 NRS 评分和尿液 OXT 浓度。结果：NRS治疗干预前后的 NRS 评分分别为 7 [6, 9]和 2 [1, 4]（中位数[四分位数间距]）。治疗前后尿液中的 OXT 水平分别为 523 [293, 743] pg/mL 和 531 [308, 887] pg/mL（中位数[四分位数间距]）。我们比较了治疗干预后 NRS 改善较大的组别和改善较小的组别。治疗干预后 NRS 改善幅度较大的一组患者的 OXT 水平上升幅度较大。然而，慢性疼痛患者尿液中 OXT 的基线浓度差异很大，尿液中 OXT 浓度的变化也不尽相同。结论：基于这项试点研究，尿液中 OXT 浓度作为慢性疼痛客观生物标志物的实用性有待进一步研究。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.