Optimizing Drug Delivery Vehicle with Multi-Criteria Decision Making (MCDM) - Based Excipient Selection

Abstract

Excipients are used in drug delivery systems as a means of effectively delivering drugs to their target site. Multi-criteria decision-making (MCDM) methods are tools for decision-making that consider multidimensional factors. Such methods are a comparative technology used in medicine that combines individual criteria into the total assessment of selected alternatives. This study aims to enhance the solubility and bioavailability of drugs through the application of MCDM-based excipient selection. By incorporating the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE), various excipients can be evaluated and ranked based on their suitability for specific applications, considering parameters related to drug solubility and bioavailability. The results highlight the potential of cyclodextrins (net flow: 0.0023) and Eudragit polymers (net flow: 0.0016) as preferred options for drug carriers, while Poloxamer 188 (P188) (net flow: -0.0030) is identified as the least preferred option. This study demonstrates the effectiveness of the PROMETHEE method in improving the performance of poorly soluble and bioavailable drugs, ultimately contributing to the development of new drug delivery systems. The findings have significant implications for therapeutic outcomes in the treatment of diseases.