Ways to overcome difficulties in diagnosing non-alcoholic fatty liver disease

Abstract

The purpose of the study is to evaluate the status and capabilities of modern types of diagnostics of non-alcoholic fatty liver disease as part of a meta-analysis of scientific data. Materials and methods. The literature search was carried out in electronic databases Cochrane Library, PubMed.gov, Elsevier.com, Google Scholar. The analysis of the data obtained was focused on works published between 2010 and 2023 (the bias in the form of later studies was used in isolated cases when it came to fundamental scientometric data). Results. After reviewing 693 scientific papers for duplication and inconsistency, 38 sources were selected. Conclusions. The analysis of scientific data revealed that despite the understanding of the pathogenetic causes of non-alcoholic fatty liver disease and the complexity of this disease, liver biopsy still remains the gold standard for assessing liver health. In this regard, there is a need to introduce accessible non-imaging tools and accurate biomarkers, with the help of which it will be possible not only to make an adequate diagnosis, but also to analyze new treatments for NAFLD in clinical trials.