Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-222-2-55-63
A. A. Goncharov, A. Sasunova, V. A. Isakov
{"title":"Comparative value of controlled attenuation (CAPc) and continuous controlled attenuation (CAP) parameters for different stages of non-alcoholic fatty liver disease","authors":"A. A. Goncharov, A. Sasunova, V. A. Isakov","doi":"10.31146/1682-8658-ecg-222-2-55-63","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-55-63","url":null,"abstract":"","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"83 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-219-11-146-152
S. V. Tarasenko, D. A. Glotov, O. D. Peskov, S. N. Sokolova, U. V. Zhuchkova, T. S. Rakhmaev, I. Bakonina, A. Bogomolov, D. O. Tyulenev, S. N. Brovkina, S. G. Bykova
The aim of the study - to analyze the pathogenesis of liver damage in COVID-19, as well as to study the features of diagnosis. Research materials: literature and own data on the peculiarities of the pathogenesis of liver damage were analyzed, as well as an assessment of laboratory and instrumental diagnostics in patients with COVID-19. The results of the research. In patients, liver damage was manifested by an increase in liver enzymes, as well as a diffuse decrease in its density during CT. The severity of the disease is caused by a cytokine storm caused by a dysfunctional immune response to the virus, viral virulence factors, as well as the presence of concomitant diseases, especially those associated with liver pathology, such as cirrhosis or steatosis. Conclusions. The new COVID-19 coronavirus infection caused by SARS-CoV-2 continues to spread worldwide. The main target is the organs of the respiratory system. However, among the patients with COVID-19, there were lesions of the central nervous system, intestines, myocardium and liver. Liver dysfunction in most cases should be considered as a result of secondary damage due to CVD, ARDS, hypoxia, multiple organ failure, exposure to immune factors, and taking hepatotoxic drugs.
{"title":"COVID-19 liver damage. Features of laboratory and instrumental diagnostics","authors":"S. V. Tarasenko, D. A. Glotov, O. D. Peskov, S. N. Sokolova, U. V. Zhuchkova, T. S. Rakhmaev, I. Bakonina, A. Bogomolov, D. O. Tyulenev, S. N. Brovkina, S. G. Bykova","doi":"10.31146/1682-8658-ecg-219-11-146-152","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-146-152","url":null,"abstract":"The aim of the study - to analyze the pathogenesis of liver damage in COVID-19, as well as to study the features of diagnosis. Research materials: literature and own data on the peculiarities of the pathogenesis of liver damage were analyzed, as well as an assessment of laboratory and instrumental diagnostics in patients with COVID-19. The results of the research. In patients, liver damage was manifested by an increase in liver enzymes, as well as a diffuse decrease in its density during CT. The severity of the disease is caused by a cytokine storm caused by a dysfunctional immune response to the virus, viral virulence factors, as well as the presence of concomitant diseases, especially those associated with liver pathology, such as cirrhosis or steatosis. Conclusions. The new COVID-19 coronavirus infection caused by SARS-CoV-2 continues to spread worldwide. The main target is the organs of the respiratory system. However, among the patients with COVID-19, there were lesions of the central nervous system, intestines, myocardium and liver. Liver dysfunction in most cases should be considered as a result of secondary damage due to CVD, ARDS, hypoxia, multiple organ failure, exposure to immune factors, and taking hepatotoxic drugs.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"120 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-222-2-89-100
S. Bulgakova, D. P. Kurmaev, E. Treneva
Aging is associated with a change in body composition, which is an increase in the proportion of fat mass, usually against with decrease in muscle mass. In addition, obesity is often associated with metabolic syndrome, type 2 diabetes mellitus (DM2), and cardiovascular diseases. Visceral obesity is more dangerous than excessive accumulation of subcutaneous fat. An accurate assessment of body composition can provide useful information about the health and functions of the body. However, it can be difficult to determine the exact content of musculoskeletal and adipose tissue in the body of geriatric patients. Anthropometric methods are easy to use and do not require complex and expensive equipment, but they are uninformative and have low accuracy. The issue of timely diagnosis of the compositional composition of the body in older age groups is relevant for predicting the risk of developing chronic non-communicable diseases, disability.
{"title":"Diagnostics of the body composition of an elderly person to assess the prognosis of his health","authors":"S. Bulgakova, D. P. Kurmaev, E. Treneva","doi":"10.31146/1682-8658-ecg-222-2-89-100","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-89-100","url":null,"abstract":"Aging is associated with a change in body composition, which is an increase in the proportion of fat mass, usually against with decrease in muscle mass. In addition, obesity is often associated with metabolic syndrome, type 2 diabetes mellitus (DM2), and cardiovascular diseases. Visceral obesity is more dangerous than excessive accumulation of subcutaneous fat. An accurate assessment of body composition can provide useful information about the health and functions of the body. However, it can be difficult to determine the exact content of musculoskeletal and adipose tissue in the body of geriatric patients. Anthropometric methods are easy to use and do not require complex and expensive equipment, but they are uninformative and have low accuracy. The issue of timely diagnosis of the compositional composition of the body in older age groups is relevant for predicting the risk of developing chronic non-communicable diseases, disability.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"112 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-219-11-75-80
I. V. Melnyk
A case from practice is presented, demonstrating the development of small-intestinal intussusception in a patient, the pathogenetic cause of which was polyps of the small intestine. Despite the fact that the patient twice, before entering the surgical clinic with acute intestinal obstruction, came to the attention of medical workers (the first time with signs of gastrointestinal bleeding, the second time with abdominal pain), the patient was not properly examined, although, retrospectively, it can be assumed that the arsenal of diagnostic methods that were at the disposal of physicians made it possible to make a correct clinical diagnosis. With a very high degree of probability, it can be argued that in both cases, the cause of the patient's problems was the polyps of the small intestine. During the last hospitalization, the patient, despite the preoperative diagnosis that was not entirely accurate in terms of the wording, but absolutely correct in terms of tactics, was promptly performed an adequate surgical intervention in terms of volume. Particular attention of surgeons is drawn to the mandatory need for careful palpation and visual revision of all parts of the small intestine when performing surgical interventions for completed small intestinal intussusceptions.
{"title":"Small intestinal polyps in adults: complications, diagnosis and treatment problems","authors":"I. V. Melnyk","doi":"10.31146/1682-8658-ecg-219-11-75-80","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-75-80","url":null,"abstract":"A case from practice is presented, demonstrating the development of small-intestinal intussusception in a patient, the pathogenetic cause of which was polyps of the small intestine. Despite the fact that the patient twice, before entering the surgical clinic with acute intestinal obstruction, came to the attention of medical workers (the first time with signs of gastrointestinal bleeding, the second time with abdominal pain), the patient was not properly examined, although, retrospectively, it can be assumed that the arsenal of diagnostic methods that were at the disposal of physicians made it possible to make a correct clinical diagnosis. With a very high degree of probability, it can be argued that in both cases, the cause of the patient's problems was the polyps of the small intestine. During the last hospitalization, the patient, despite the preoperative diagnosis that was not entirely accurate in terms of the wording, but absolutely correct in terms of tactics, was promptly performed an adequate surgical intervention in terms of volume. Particular attention of surgeons is drawn to the mandatory need for careful palpation and visual revision of all parts of the small intestine when performing surgical interventions for completed small intestinal intussusceptions.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"110 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-219-11-5-11
Laiegh Mohsen, Fakheri Hafez, Rasouli Mehdi
Background: Histamine receptors are involved to regulate lipid metabolism, so the hypothesis will arise that pathological states with abnormal histamine levels are associated with altered plasma lipids. Objectives: To study the profile of plasma lipids in patients with gastritis and peptic ulcer (GPU). Methods: In a case-control study, 70 dyspeptic patients were selected according to clinical criteria and using gastroduodenoscopy and compared with sex and age matched normal subjects. Results: There were no significant differences in age, sex, and the prevalence of hypertension and diabetes between two groups. But allergy, the familial history of allergy and dyspeptic and H. pylori infection were more prevalent in case group compared with controls. The levels of the indices of inflammation and body hydration were the same in two groups. Patients with dyspeptic compared with the controls had the lower concentrations of serum triglyceride (139.2±44.3 vs. 153.4±91.3), p≤0.553), total cholesterol (174.6±32.4 vs. 192.8±52.0, p≤0.073, LDLc (93.4±20.2 vs. 105.4±32.2, p≤0.015) and NonHDLc (130.2±38.1 vs. 159.2±42.2, p≤0.008). The level of HDL had not a significant change (43.4±7.8 vs. 43.5±12.7, p≤0.930). Dyspeptic state had negative significant correlation with total cholesterol, LDLc and NonHDLc but not HDLc. Neither the markers of inflammation nor the indices of body hydration had significant correlation with GPU. Conclusions: The GPU patients relative to normal group had the lower levels of serum lipids. The hypolipemic effects may be attributed to increased level of histamine in GPU patients.
背景：组胺受体参与调节脂质代谢，因此假设组胺水平异常的病理状态与血浆脂质的改变有关。研究目的研究胃炎和消化性溃疡（GPU）患者的血浆脂质概况。方法：在一项病例对照研究中，对胃炎和消化性溃疡（GPU）患者的血脂进行分析：在一项病例对照研究中，根据临床标准和胃十二指肠镜检查筛选出 70 名消化不良患者，并与性别和年龄匹配的正常人进行比较。结果两组患者在年龄、性别、高血压和糖尿病患病率方面无明显差异。但病例组与对照组相比，过敏、家族过敏史、消化不良和幽门螺杆菌感染的发病率更高。两组患者的炎症指数和体内水分含量水平相同。与对照组相比，消化不良患者的血清甘油三酯浓度较低（139.2±44.3 vs. 153.4±91.3），P≤0.553）、总胆固醇（174.6±32.4 vs. 192.8±52.0，p≤0.073）、低密度脂蛋白胆固醇（93.4±20.2 vs. 105.4±32.2，p≤0.015）和非高密度脂蛋白胆固醇（130.2±38.1 vs. 159.2±42.2，p≤0.008）。高密度脂蛋白水平变化不大（43.4±7.8 vs. 43.5±12.7，p≤0.930）。消化不良状态与总胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇呈负相关，但与高密度脂蛋白胆固醇无关。炎症指标和身体水合指数与 GPU 均无明显相关性。结论：与正常组相比，GPU 患者的血清脂质水平较低。低血脂效应可能是由于 GPU 患者体内组胺水平升高所致。
{"title":"Gastritis and peptic ulcers are associated with the lower levels of plasma lipids: possible involvement of histamine","authors":"Laiegh Mohsen, Fakheri Hafez, Rasouli Mehdi","doi":"10.31146/1682-8658-ecg-219-11-5-11","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-5-11","url":null,"abstract":"Background: Histamine receptors are involved to regulate lipid metabolism, so the hypothesis will arise that pathological states with abnormal histamine levels are associated with altered plasma lipids. Objectives: To study the profile of plasma lipids in patients with gastritis and peptic ulcer (GPU). Methods: In a case-control study, 70 dyspeptic patients were selected according to clinical criteria and using gastroduodenoscopy and compared with sex and age matched normal subjects. Results: There were no significant differences in age, sex, and the prevalence of hypertension and diabetes between two groups. But allergy, the familial history of allergy and dyspeptic and H. pylori infection were more prevalent in case group compared with controls. The levels of the indices of inflammation and body hydration were the same in two groups. Patients with dyspeptic compared with the controls had the lower concentrations of serum triglyceride (139.2±44.3 vs. 153.4±91.3), p≤0.553), total cholesterol (174.6±32.4 vs. 192.8±52.0, p≤0.073, LDLc (93.4±20.2 vs. 105.4±32.2, p≤0.015) and NonHDLc (130.2±38.1 vs. 159.2±42.2, p≤0.008). The level of HDL had not a significant change (43.4±7.8 vs. 43.5±12.7, p≤0.930). Dyspeptic state had negative significant correlation with total cholesterol, LDLc and NonHDLc but not HDLc. Neither the markers of inflammation nor the indices of body hydration had significant correlation with GPU. Conclusions: The GPU patients relative to normal group had the lower levels of serum lipids. The hypolipemic effects may be attributed to increased level of histamine in GPU patients.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"108 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-222-2-50-54
A. V. Pashentseva, L. Y. Shvan, I. V. Gubareva, G. V. Supornik
The increase in the prevalence of obesity in recent decades is an urgent medical and social problem for all countries, increasing the cost of medical care and worsening the quality of life of patients. Obesity is an independent risk factor for the development of a number of chronic non-infectious diseases, including respiratory diseases. The presence of excess body weight not only provokes the development of bronchopulmonary pathology, but also aggravates its course. The article discusses the mechanisms of the impact of obesity on the pathogenesis of diseases such as bronchial asthma, chronic obstructive pulmonary disease and coronavirus infection.
{"title":"Obesity provokes the development of bronchopulmonary pathology and aggravates its course","authors":"A. V. Pashentseva, L. Y. Shvan, I. V. Gubareva, G. V. Supornik","doi":"10.31146/1682-8658-ecg-222-2-50-54","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-50-54","url":null,"abstract":"The increase in the prevalence of obesity in recent decades is an urgent medical and social problem for all countries, increasing the cost of medical care and worsening the quality of life of patients. Obesity is an independent risk factor for the development of a number of chronic non-infectious diseases, including respiratory diseases. The presence of excess body weight not only provokes the development of bronchopulmonary pathology, but also aggravates its course. The article discusses the mechanisms of the impact of obesity on the pathogenesis of diseases such as bronchial asthma, chronic obstructive pulmonary disease and coronavirus infection.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"122 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140381255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-219-11-163-166
S. Styazhkina, R. R. Shaymukhametov, T. E. Chernyshova, D. G. Amarantov, S. A. Denisov
Zarivchatsky Mikhail Fedorovich - surgeon, Honored Doctor of the Russian Federation, Academician of the Academy of Natural Sciences, former Vice-Rector for academic work, head of the Department of Surgical Diseases of Medical Faculty of Prevention, Perm State Medical University named after Academician E. A. Wagner, Doctor of Medical Sciences, Professor Aim to highlight the life path, the biography of the great doctor Zarivchatsky Mikhail Fedorovich and his contribution to the development of surgery, science and healthcare of the Udmurt Republic Materials and research methods. To achieve this goal, it was carried out a theoretical analysis and generalization of literature data on the topic.
{"title":"Tribute to the memory of Zarivchatsky Mikhail Fedorovich - surgeon, organizer of health care, professor of Perm State Medical University","authors":"S. Styazhkina, R. R. Shaymukhametov, T. E. Chernyshova, D. G. Amarantov, S. A. Denisov","doi":"10.31146/1682-8658-ecg-219-11-163-166","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-163-166","url":null,"abstract":"Zarivchatsky Mikhail Fedorovich - surgeon, Honored Doctor of the Russian Federation, Academician of the Academy of Natural Sciences, former Vice-Rector for academic work, head of the Department of Surgical Diseases of Medical Faculty of Prevention, Perm State Medical University named after Academician E. A. Wagner, Doctor of Medical Sciences, Professor Aim to highlight the life path, the biography of the great doctor Zarivchatsky Mikhail Fedorovich and his contribution to the development of surgery, science and healthcare of the Udmurt Republic Materials and research methods. To achieve this goal, it was carried out a theoretical analysis and generalization of literature data on the topic.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"33 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-219-11-160-162
S. Kutia, N. Nikolaeva
The article presents a translation of the chapter 404 of the work of Austrian anatomist Josef Hyrtl "Onomatologia anatomica" (1880, Vien), where author provides own point of view on discovery of ileo-caecal valve (Bauhin’s valve). According to Hyrtl, the Italian anatomist Gabriele Fallopio (1523-1562) should be considered the discoverer of this structure.
{"title":"History of discovery of ileo-caecal valve: Josef Hyrtl’s version","authors":"S. Kutia, N. Nikolaeva","doi":"10.31146/1682-8658-ecg-219-11-160-162","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-160-162","url":null,"abstract":"The article presents a translation of the chapter 404 of the work of Austrian anatomist Josef Hyrtl \"Onomatologia anatomica\" (1880, Vien), where author provides own point of view on discovery of ileo-caecal valve (Bauhin’s valve). According to Hyrtl, the Italian anatomist Gabriele Fallopio (1523-1562) should be considered the discoverer of this structure.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"27 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-222-2-149-155
E. Treneva, S. Bulgakova, D. P. Kurmaev, L. A. Sharonova, Y. Dolgikh
Adipose tissue is an active endocrine organ that regulates energy homeostasis throughout the body by releasing hundreds of biologically active substances called adipokines. Dysregulation of adipokines is a key feature of insulin resistance with the development of metabolic syndrome and type 2 diabetes mellitus, which is an age-dependent pathology. In turn, dysregulation of adipokines and insulin resistance are associated with the development of metabolic deficiency and senile asthenia syndrome in older age groups. Previous studies have shown that the absence of insulin resistance and low prevalence of diabetes among centenarians are metabolic prerequisites for increased lifespan, suggesting a possible role for adipokine homeostasis in healthy longevity. Among numerous adipokines, adiponectin is considered a protective factor, showing a negative correlation with major metabolic disorders associated with age and obesity, and a positive association with life expectancy and insulin sensitivity among centenarians. Despite all the apparent protective effects of adiponectin, large-scale epidemiological studies have revealed the opposite aspect of adiponectin as a predictor of all-cause mortality and cardiovascular disease in patients with heart failure as well as kidney disease. In this review, the clinical significance of adiponectin is considered in centenarians from the point of view of the development of the main geriatric syndrome - senile asthenia, as well as cardiovascular risk and mortality.
{"title":"Adipocines and longevity: connections and paradoxes","authors":"E. Treneva, S. Bulgakova, D. P. Kurmaev, L. A. Sharonova, Y. Dolgikh","doi":"10.31146/1682-8658-ecg-222-2-149-155","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-149-155","url":null,"abstract":"Adipose tissue is an active endocrine organ that regulates energy homeostasis throughout the body by releasing hundreds of biologically active substances called adipokines. Dysregulation of adipokines is a key feature of insulin resistance with the development of metabolic syndrome and type 2 diabetes mellitus, which is an age-dependent pathology. In turn, dysregulation of adipokines and insulin resistance are associated with the development of metabolic deficiency and senile asthenia syndrome in older age groups. Previous studies have shown that the absence of insulin resistance and low prevalence of diabetes among centenarians are metabolic prerequisites for increased lifespan, suggesting a possible role for adipokine homeostasis in healthy longevity. Among numerous adipokines, adiponectin is considered a protective factor, showing a negative correlation with major metabolic disorders associated with age and obesity, and a positive association with life expectancy and insulin sensitivity among centenarians. Despite all the apparent protective effects of adiponectin, large-scale epidemiological studies have revealed the opposite aspect of adiponectin as a predictor of all-cause mortality and cardiovascular disease in patients with heart failure as well as kidney disease. In this review, the clinical significance of adiponectin is considered in centenarians from the point of view of the development of the main geriatric syndrome - senile asthenia, as well as cardiovascular risk and mortality.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"123 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.31146/1682-8658-ecg-222-2-131-140
E. D. Bulgakova, E. Shrayner, A. I. Khavkin, G. Lifshits, K. Nikolaychuk, M. Denisov
Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.
{"title":"The relationship between gastroesophageal pathogenic reflux and metabolic syndrome","authors":"E. D. Bulgakova, E. Shrayner, A. I. Khavkin, G. Lifshits, K. Nikolaychuk, M. Denisov","doi":"10.31146/1682-8658-ecg-222-2-131-140","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-131-140","url":null,"abstract":"Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"115 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：