The Role of Quorum Quenching in Medical Application

Abstract

The attempts are continuing in the various fields of life sciences to resolve a big problem, which is the ability of bacteria to cause pathogenicity for humans, animals, and plants, whether by chemical or biological methods and in ways that are hoped to be safe. Among these attempts, the control of the Quorum Sensing (QS) mechanism that occurs naturally in bacteria under certain conditions helps to increase the virulence of bacteria, starting from its ability to adhere and form a biofilm. Then, the tissues are invaded with various enzymes according to the tissue type, increasing antibiotic resistance. Therefore, the idea came to solve these problems through a mechanism opposite to the Quorum Quenching (QQ), which lies in the investigation of substances that can disrupt the QS pathway, whether at the molecular level or the physiological level, as well as benefiting from different organisms (Prokaryotes or Eukaryotes) that live in the same environment and produce substances that inhibit bacterial signaling molecules. Lastly, the discovery of varying novel QQ agents from extreme environmental bacteria will be most interesting in the future. Keywords: Quorum sensing, quorum quenching, acyl homoserine lactones, medical application