Green synthesis of selenium nanoparticles capped by Tithonia diversifolia pectin for anti‐inflammation activity

IF 1.3 Q3 CHEMISTRY, MULTIDISCIPLINARY Vietnam Journal of Chemistry Pub Date : 2024-03-14 DOI:10.1002/vjch.202300284
Nguyen Thi Hanh, Tran Thi Thanh Thuy, Tran Huu Quang
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Abstract

This work reports a green method to synthesize pectin‐capped selenium nanoparticles (PT‐SeNPs) using ascorbic acid as a reductant under mild conditions. Pectin was extracted from Tithonia diversifolia (Hemsley) A. Gray plant. Pectin played the role of a capping agent preventing the agglomeration of selenium nanoparticles. The synthesized PT‐SeNPs were characterized by UV–Vis spectrophotometry, EDX spectroscopy, TEM, DLS, FT‐IR, XRD, and TG‐DTA. The TEM and DLS techniques revealed monodispersed spherical selenium nanoparticles with sizes range of 100–200 nm. The amorphous PT‐SeNPs showed a phase transformation of nanostructure at 132 °C and a sublimation at 486 °C. The anti‐inflammatory of the obtained PT‐SeNPs was investigated in ethyl phenylpropiolate (EPP)‐induced rats. Rats treated with PT‐SeNPs exhibited ear edema inhibitions of 34.8%, 43.3%, and 46.7%, respectively at 30, 60 and 90 min after EPP injection.
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用多孔蓼果胶绿色合成具有抗炎活性的硒纳米颗粒
本研究报告了一种在温和条件下以抗坏血酸为还原剂合成果胶封端硒纳米粒子(PT-SeNPs)的绿色方法。果胶是从 Tithonia diversifolia (Hemsley) A. Gray 植物中提取的。果胶起着封盖剂的作用,可防止硒纳米粒子团聚。合成的 PT-SeNPs 通过紫外可见分光光度法、EDX 光谱法、TEM、DLS、FT-IR、XRD 和 TG-DTA 进行了表征。TEM 和 DLS 技术显示了单分散球形硒纳米粒子,尺寸范围为 100-200 nm。无定形的 PT-SeNPs 在 132 °C 时发生了纳米结构的相变,并在 486 °C 时升华。研究人员在苯丙酸乙酯(EPP)诱导的大鼠身上考察了所获得的 PT-SeNPs 的抗炎性。注射 EPP 后 30、60 和 90 分钟,用 PT-SeNPs 处理的大鼠的耳部水肿抑制率分别为 34.8%、43.3% 和 46.7%。
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来源期刊
Vietnam Journal of Chemistry
Vietnam Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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1.70
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