Tran Trong Binh, Nguyen Thi Thuy Luyen, Le Thi Hoa, Nguyen Khanh Hung, Nguyen Phi Linh, Cao Nhu Anh, Le Thi Phuong, Tran Le Quan, Nguyen Huy Du
Abstract This research has established a totally synthetic route for 6‐C‐prenylated hydroxyflavones (6‐PHyFVs) via the dehydrogenation, employing iodine in pyridine, of 6‐C‐prenylated hydroxyflavanones (6‐PHyFVNs) which were totally synthesized by prior method. The experimental results confirmed that our synthetic route effectively produced 6‐PHyFVs with the desired substitution pattern on the aromatic rings, along with the specified 6‐C‐prenyl chain length. Thanks to the synthetic route, this research identified 6‐PHyFVs as novel anticancer agents against breast cancer. Among the synthesized 6‐C‐prenyl flavonoids, compound 9c (6‐(3,3‐diethylallyl)diosmetin) exhibited the most promising profile, showing potent cytotoxicity toward MCF‐7 breast cancer cells (IC 50 = 9.22 µM) and a selectivity index greater than 10 relative to chondrocytes.
{"title":"Total synthesis and cytotoxic evaluation of 6‐C‐prenylated flavones against MCF‐7 cells","authors":"Tran Trong Binh, Nguyen Thi Thuy Luyen, Le Thi Hoa, Nguyen Khanh Hung, Nguyen Phi Linh, Cao Nhu Anh, Le Thi Phuong, Tran Le Quan, Nguyen Huy Du","doi":"10.1002/vjch.70109","DOIUrl":"https://doi.org/10.1002/vjch.70109","url":null,"abstract":"Abstract This research has established a totally synthetic route for 6‐C‐prenylated hydroxyflavones (6‐PHyFVs) via the dehydrogenation, employing iodine in pyridine, of 6‐C‐prenylated hydroxyflavanones (6‐PHyFVNs) which were totally synthesized by prior method. The experimental results confirmed that our synthetic route effectively produced 6‐PHyFVs with the desired substitution pattern on the aromatic rings, along with the specified 6‐C‐prenyl chain length. Thanks to the synthetic route, this research identified 6‐PHyFVs as novel anticancer agents against breast cancer. Among the synthesized 6‐C‐prenyl flavonoids, compound 9c (6‐(3,3‐diethylallyl)diosmetin) exhibited the most promising profile, showing potent cytotoxicity toward MCF‐7 breast cancer cells (IC 50 = 9.22 µM) and a selectivity index greater than 10 relative to chondrocytes.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"64 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ngoc Tran, Thien An Le, An Nang Vu, Quoc Thiet Nguyen, Pei Yuin Keng, Tiến Khoa Lê, Tien Khoa Le, Tien Khoa Le
Abstract In this study, we aimed to synthesize heterogeneous and recoverable Cu 2 O‐loaded perlite catalysts for the rapid conversion of 4‐nitroaniline to p ‐phenylenediamine utilizing NaBH 4 as a reducing agent. The catalysts were prepared by immobilizing Cu(OH) 2 onto perlite granules at varying Cu 2+ molar concentrations, followed by reduction with ascorbic acid. These materials were characterized using XRD, FESEM, EDS, FTIR and N 2 adsorption‐desorption techniques. The experimental results revealed that increasing the Cu 2+ concentration in the synthesis solution significantly enhanced the Cu 2 O content on the perlite surface, as well as the roughness and specific surface area of the catalysts. These improvements in structure and surface properties led to a marked increase in catalytic activity, enabling the complete conversion of 4‐nitroaniline to p ‐phenylenediamine within just 2 min. Notably, the incorporation of perlite allowed the catalysts to float on the water surface, facilitating easy recovery and reuse.
{"title":"Synthesis of Cu <sub>2</sub> O‐loaded perlite granules as floating catalysts for the rapid reduction of 4‐nitroaniline","authors":"Ngoc Tran, Thien An Le, An Nang Vu, Quoc Thiet Nguyen, Pei Yuin Keng, Tiến Khoa Lê, Tien Khoa Le, Tien Khoa Le","doi":"10.1002/vjch.70093","DOIUrl":"https://doi.org/10.1002/vjch.70093","url":null,"abstract":"Abstract In this study, we aimed to synthesize heterogeneous and recoverable Cu 2 O‐loaded perlite catalysts for the rapid conversion of 4‐nitroaniline to p ‐phenylenediamine utilizing NaBH 4 as a reducing agent. The catalysts were prepared by immobilizing Cu(OH) 2 onto perlite granules at varying Cu 2+ molar concentrations, followed by reduction with ascorbic acid. These materials were characterized using XRD, FESEM, EDS, FTIR and N 2 adsorption‐desorption techniques. The experimental results revealed that increasing the Cu 2+ concentration in the synthesis solution significantly enhanced the Cu 2 O content on the perlite surface, as well as the roughness and specific surface area of the catalysts. These improvements in structure and surface properties led to a marked increase in catalytic activity, enabling the complete conversion of 4‐nitroaniline to p ‐phenylenediamine within just 2 min. Notably, the incorporation of perlite allowed the catalysts to float on the water surface, facilitating easy recovery and reuse.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"64 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anh‐Tuan Pham, Pierre–Alain Duc, Ha Thi Ha, Mai Quan Doan, Dieu Vinh Tran
Abstract Epoxy resin, a pivotal polymer with extensive applications, is hampered by inherent inflexibility and brittleness, limiting its potential in scenarios demanding resilience against external forces. This study addresses this limitation by introducing an innovative modification through the integration of epoxy‐oligoester (EOS), derived as a byproduct of unsaturated polyester resin synthesis. EOS, with an epoxy group content of 7.5% and an acid value of 0.25 mg KOH/g, functions as an effective internal toughening agent for epoxy resin. At 15 wt%, EOS significantly augments impact strength (67.7%) and fracture toughness (92.1%), achieved by reducing network density from 0.792 × 10 −3 to 0.678 × 10 −3 mol cm −3 , resulting in lower storage modulus ( E ′) and glass transition temperature. Additionally, the addition of 15 wt% EOS retards delamination and amplifies delamination energy. Mode I critical strain energy release rate (GIC) increases by 51.2%, from 608.1 to 911.5 J/m 2 , and Mode II critical strain energy release rate (GIP) rises by 51.7%, from 664.0 to 1007.6 J/m 2 . These findings underscore the promise of EOS‐modified epoxy in industries necessitating materials with elevated fracture toughness and superior resistance to delamination, such as transportation, maritime, and automotive sectors.
{"title":"Improving impact strength and fracture toughness of epoxy resin through oligoester—A byproduct derived from the unsaturated polyester resin manufacturing process","authors":"Anh‐Tuan Pham, Pierre–Alain Duc, Ha Thi Ha, Mai Quan Doan, Dieu Vinh Tran","doi":"10.1002/vjch.202400247","DOIUrl":"https://doi.org/10.1002/vjch.202400247","url":null,"abstract":"Abstract Epoxy resin, a pivotal polymer with extensive applications, is hampered by inherent inflexibility and brittleness, limiting its potential in scenarios demanding resilience against external forces. This study addresses this limitation by introducing an innovative modification through the integration of epoxy‐oligoester (EOS), derived as a byproduct of unsaturated polyester resin synthesis. EOS, with an epoxy group content of 7.5% and an acid value of 0.25 mg KOH/g, functions as an effective internal toughening agent for epoxy resin. At 15 wt%, EOS significantly augments impact strength (67.7%) and fracture toughness (92.1%), achieved by reducing network density from 0.792 × 10 −3 to 0.678 × 10 −3 mol cm −3 , resulting in lower storage modulus ( E ′) and glass transition temperature. Additionally, the addition of 15 wt% EOS retards delamination and amplifies delamination energy. Mode I critical strain energy release rate (GIC) increases by 51.2%, from 608.1 to 911.5 J/m 2 , and Mode II critical strain energy release rate (GIP) rises by 51.7%, from 664.0 to 1007.6 J/m 2 . These findings underscore the promise of EOS‐modified epoxy in industries necessitating materials with elevated fracture toughness and superior resistance to delamination, such as transportation, maritime, and automotive sectors.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"63 2","pages":"338-347"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/vjch.202400247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract COVID‐19 is an infectious disease caused by SARS‐CoV‐2 that is spreading in many countries around the world. In attempts to discover compounds that have an effect on SARS‐CoV‐2, many important molecular targets have been identified, involved in viral infection and replication including spike protein, main protease, capthesin L, helicase, 2‐O‐methyltransferase, endoRNAse. In this study, we would like to identify pot ential flavonoids that could simultaneously inhibit 3CLP, capthesin L, endoRNAse, 2‐O‐methyltransferase, and PLP from a 4389‐flavonoid database using molecular docking, molecular dynamics simulation, pharmacokinetic and toxicity prediction. Out of 4389 compounds, 79 potential flavonoids that could simultaneously inhibit five COVID‐19 molecular targets were identified. Pharmacokinetic and toxicity prediction showed that these compounds were well absorbed from the gastrointestinal tract and safe for human use. These potential compounds were noteworthy during drug research and development for SARS‐CoV‐2 treatment.
{"title":"Flavonoids as potential agents for development of multi‐target drugs for covid‐19 treatment: An in silico study","authors":"Nguyễn Thị Thu Hằng, N. Van Phuong","doi":"10.1002/vjch.202100108","DOIUrl":"https://doi.org/10.1002/vjch.202100108","url":null,"abstract":"Abstract COVID‐19 is an infectious disease caused by SARS‐CoV‐2 that is spreading in many countries around the world. In attempts to discover compounds that have an effect on SARS‐CoV‐2, many important molecular targets have been identified, involved in viral infection and replication including spike protein, main protease, capthesin L, helicase, 2‐O‐methyltransferase, endoRNAse. In this study, we would like to identify pot ential flavonoids that could simultaneously inhibit 3CLP, capthesin L, endoRNAse, 2‐O‐methyltransferase, and PLP from a 4389‐flavonoid database using molecular docking, molecular dynamics simulation, pharmacokinetic and toxicity prediction. Out of 4389 compounds, 79 potential flavonoids that could simultaneously inhibit five COVID‐19 molecular targets were identified. Pharmacokinetic and toxicity prediction showed that these compounds were well absorbed from the gastrointestinal tract and safe for human use. These potential compounds were noteworthy during drug research and development for SARS‐CoV‐2 treatment.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"23 1","pages":"281 - 296"},"PeriodicalIF":0.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83295802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Thi Ai My, Nguyen Ho Vu Phong, N. Nhan, P. Quy, N. D. Nguyen, N. Nhung
Abstract Baloxavir marboxil (D1), Baricitinib (D2), Galidesivir (D3), Nitazoxanide (D4), and Oseltamivir (D5) are well‐known performing broad‐spectrum activity against a variety of viruses, thus holding high potentiality towards SARS‐CoV‐2. Quantum properties were examined using density functional theory (DFT). The inhibitability of the drugs towards Angiotensin‐converting enzyme 2 (ACE2) and SARS‐CoV‐2 main protease (6LU7) was evaluated by molecular docking simulation, while their bio‐compatibility was justified by physicochemical properties obtained from QSARIS‐based analysis in reference to Lipinski's rule of five. Quantum analysis suggests that the compounds are highly favourable for intermolecular interaction towards protein structures. Given ligand‐ACE2 systems, the inhibitory effectiveness follows the order D3‐ACE2 > D4‐ACE2 > D2‐ACE2 > D5‐ACE2 > D1‐ACE2; and the corresponding order for ligand‐6LU7 systems is D2‐6LU7 > D4‐6LU7 > D3‐6LU7 > D5‐6LU7 > D1‐6LU7. Galidesivir is predicted as the most effective inhibitor towards both targeted protein structures (DSaverage ‐13.1 kcal.mol‐1) and the most bio‐compatible molecule (Mass 264.9 amu; LogP ‐0.9; Polarisability 26.8 Å3). The theoretical screening suggests all drugs, especially Galidesivir (D3), promising for treatment of SARS‐CoV‐2 infection and encourages in‐related clinical trials.
{"title":"An in silico study on inhibitability of Baloxavir marboxil, Baricitinib, Galidesivir, Nitazoxanide, and Oseltamivir against SARS‐CoV‐2","authors":"Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Thi Ai My, Nguyen Ho Vu Phong, N. Nhan, P. Quy, N. D. Nguyen, N. Nhung","doi":"10.1002/vjch.202100145","DOIUrl":"https://doi.org/10.1002/vjch.202100145","url":null,"abstract":"Abstract Baloxavir marboxil (D1), Baricitinib (D2), Galidesivir (D3), Nitazoxanide (D4), and Oseltamivir (D5) are well‐known performing broad‐spectrum activity against a variety of viruses, thus holding high potentiality towards SARS‐CoV‐2. Quantum properties were examined using density functional theory (DFT). The inhibitability of the drugs towards Angiotensin‐converting enzyme 2 (ACE2) and SARS‐CoV‐2 main protease (6LU7) was evaluated by molecular docking simulation, while their bio‐compatibility was justified by physicochemical properties obtained from QSARIS‐based analysis in reference to Lipinski's rule of five. Quantum analysis suggests that the compounds are highly favourable for intermolecular interaction towards protein structures. Given ligand‐ACE2 systems, the inhibitory effectiveness follows the order D3‐ACE2 > D4‐ACE2 > D2‐ACE2 > D5‐ACE2 > D1‐ACE2; and the corresponding order for ligand‐6LU7 systems is D2‐6LU7 > D4‐6LU7 > D3‐6LU7 > D5‐6LU7 > D1‐6LU7. Galidesivir is predicted as the most effective inhibitor towards both targeted protein structures (DSaverage ‐13.1 kcal.mol‐1) and the most bio‐compatible molecule (Mass 264.9 amu; LogP ‐0.9; Polarisability 26.8 Å3). The theoretical screening suggests all drugs, especially Galidesivir (D3), promising for treatment of SARS‐CoV‐2 infection and encourages in‐related clinical trials.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"73 1","pages":"333 - 345"},"PeriodicalIF":0.9,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85817632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Van Chen, P. Quy, Ly Nguyen Hai Du, T. Cuong, Nguyen Thanh Triet, Nguyen Thi Thu Thuy, N. Nhung
Abstract Berberine (V1), lycorine (V2), hemanthamine (V3), aloperin (V4), dendrobine (V5) possess structural frameworks resembling known anti‐influenza and anti‐SARS‐CoV‐2 drugs, thus subjected for a computational screening. Their quantum properties were examined using density functional theory (DFT); the ligand‐protein inhibitability was evaluated using molecular docking simulation; physicochemical properties were obtained from QSARIS‐based analysis in reference to Lipinski's rule of five; pharmacokinetic parameters were assessed by ADMET‐based analysis. DFT calculations indicate that there are no abnormal bonding constraints observed; NBO analysis suggests all possessing favorable electric configurations for intermolecular inhibition. Regarding ligand‐2VIU, the order for static inhibitability is V3‐2VIU > V2‐2VIU > V1‐2VIU > V5‐2VIU > V4‐2VIU; Regarding ligand‐6LU7, the corresponding order follows: V2‐6LU7 > V3‐6LU7 > V1‐6LU7 > V5‐6LU7 > V4‐6LU7. An exceptional hydrophilic bonding (π‐cation) with the associated Gibbs free energy of ‐10.9 kcal.mol‐1 is detected in inhibitory complex V1‐2VIU. QSARIS‐based analysis reveals that all the candidates are highly bio‐compatible. ADMET‐based analysis specifies V2 and V3 as being safe and suitable for the use as orally administrated drugs. The results encourage further investigations for more in‐depth mechanisms and experimental validations, such as molecular dynamics simulation and in vitro enzyme assays.
{"title":"Theoretical study on inhibitability of some natural alkaloids against influenza virus hemagglutinin and SARS‐CoV‐2 main protease","authors":"Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Van Chen, P. Quy, Ly Nguyen Hai Du, T. Cuong, Nguyen Thanh Triet, Nguyen Thi Thu Thuy, N. Nhung","doi":"10.1002/vjch.202100175","DOIUrl":"https://doi.org/10.1002/vjch.202100175","url":null,"abstract":"Abstract Berberine (V1), lycorine (V2), hemanthamine (V3), aloperin (V4), dendrobine (V5) possess structural frameworks resembling known anti‐influenza and anti‐SARS‐CoV‐2 drugs, thus subjected for a computational screening. Their quantum properties were examined using density functional theory (DFT); the ligand‐protein inhibitability was evaluated using molecular docking simulation; physicochemical properties were obtained from QSARIS‐based analysis in reference to Lipinski's rule of five; pharmacokinetic parameters were assessed by ADMET‐based analysis. DFT calculations indicate that there are no abnormal bonding constraints observed; NBO analysis suggests all possessing favorable electric configurations for intermolecular inhibition. Regarding ligand‐2VIU, the order for static inhibitability is V3‐2VIU > V2‐2VIU > V1‐2VIU > V5‐2VIU > V4‐2VIU; Regarding ligand‐6LU7, the corresponding order follows: V2‐6LU7 > V3‐6LU7 > V1‐6LU7 > V5‐6LU7 > V4‐6LU7. An exceptional hydrophilic bonding (π‐cation) with the associated Gibbs free energy of ‐10.9 kcal.mol‐1 is detected in inhibitory complex V1‐2VIU. QSARIS‐based analysis reveals that all the candidates are highly bio‐compatible. ADMET‐based analysis specifies V2 and V3 as being safe and suitable for the use as orally administrated drugs. The results encourage further investigations for more in‐depth mechanisms and experimental validations, such as molecular dynamics simulation and in vitro enzyme assays.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"9 1","pages":"502 - 517"},"PeriodicalIF":0.9,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90137613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Coronavirus infectious disease 2019 (COVID‐19) is an infectious disease of the human respiratory tract caused by the SARS‐CoV‐2 virus. Spike protein is a class I glycoprotein trimeric TM involved in viral entry and infection. Four major targets to inhibit the SARS‐CoV‐2 virus are spike protein, angiotensin‐converting enzyme 2 (ACE2), main protease and the enzyme RNA‐dependent RNA polymerase (RdRp). In this study, we evaluated the inhibitory potential of natural antiviral compounds against spike protein, ACE2, main protease, RdRp targets by molecular docking and molecular dynamics simulations. Lipinski Rule of Five was used to evaluate the drug‐like properties of these compounds. The pkCSM tool was used to assess the pharmacokinetic parameters of prospective substances. Based on the ChemFaces database, we have collected 273 natural antiviral compounds. The results showed that the 7/273 compounds with the most potential to inhibit SARS‐CoV‐2 were: hinokiflavone, sotetsuflavone, mulberroside C, daphnoretin, morellic acid, digitoxin, and hypericin. Among them, sotetsuflavone is the most potent compound that inhibits four targets, with drug‐like properties, good intestinal absorption, and low toxicity. The molecular dynamics simulation results of the complexes are also relatively stable. As a results, in vitro and in vivo test should be carried out to verify the potential for COVID‐19 treatment of this compound.
{"title":"In silico screening of natural antivirals as potential inhibitors of SARS‐CoV‐2 virus","authors":"T. Hằng, Do Thi Hong Khanh, B. Tùng","doi":"10.1002/vjch.202100187","DOIUrl":"https://doi.org/10.1002/vjch.202100187","url":null,"abstract":"Abstract Coronavirus infectious disease 2019 (COVID‐19) is an infectious disease of the human respiratory tract caused by the SARS‐CoV‐2 virus. Spike protein is a class I glycoprotein trimeric TM involved in viral entry and infection. Four major targets to inhibit the SARS‐CoV‐2 virus are spike protein, angiotensin‐converting enzyme 2 (ACE2), main protease and the enzyme RNA‐dependent RNA polymerase (RdRp). In this study, we evaluated the inhibitory potential of natural antiviral compounds against spike protein, ACE2, main protease, RdRp targets by molecular docking and molecular dynamics simulations. Lipinski Rule of Five was used to evaluate the drug‐like properties of these compounds. The pkCSM tool was used to assess the pharmacokinetic parameters of prospective substances. Based on the ChemFaces database, we have collected 273 natural antiviral compounds. The results showed that the 7/273 compounds with the most potential to inhibit SARS‐CoV‐2 were: hinokiflavone, sotetsuflavone, mulberroside C, daphnoretin, morellic acid, digitoxin, and hypericin. Among them, sotetsuflavone is the most potent compound that inhibits four targets, with drug‐like properties, good intestinal absorption, and low toxicity. The molecular dynamics simulation results of the complexes are also relatively stable. As a results, in vitro and in vivo test should be carried out to verify the potential for COVID‐19 treatment of this compound.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"6 1","pages":"211 - 222"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84443870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Quang, Le Ngoc Anh, T. H. Hanh, N. X. Cuong, N. Ngan, N. Q. Trung, N. H. Nam
{"title":"Cytotoxic and antimicrobial benzodiazepine and phenolic metabolites from Aspergillus ostianus IMBC-NMTP03","authors":"T. Quang, Le Ngoc Anh, T. H. Hanh, N. X. Cuong, N. Ngan, N. Q. Trung, N. H. Nam","doi":"10.1002/VJCH.202100032","DOIUrl":"https://doi.org/10.1002/VJCH.202100032","url":null,"abstract":"","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"3 1","pages":"660-666"},"PeriodicalIF":0.9,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81396453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mg2+ embedded MIL-101(Cr)-NH2 framework for improved CO2 adsorption and CO2/N2 selectivity","authors":"Duong Tuan Quang","doi":"10.1002/VJCH.202100035","DOIUrl":"https://doi.org/10.1002/VJCH.202100035","url":null,"abstract":"","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"3 1","pages":"667-675"},"PeriodicalIF":0.9,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84184951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. A. Adole, R. More, R. Shinde, Sunil L. Dhonnar, Bapusonu Jagdale, S. Shinde, A. V. Patil, T. B. Pawar
{"title":"Spectroscopic (FTIR and UV), quantum Chemical, antifungal and antioxidant investigations of (E)-7-(4-(trifluoromethyl)benzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one: A combined experimental and theoretical study","authors":"V. A. Adole, R. More, R. Shinde, Sunil L. Dhonnar, Bapusonu Jagdale, S. Shinde, A. V. Patil, T. B. Pawar","doi":"10.1002/VJCH.202100034","DOIUrl":"https://doi.org/10.1002/VJCH.202100034","url":null,"abstract":"","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"72 1","pages":"689-700"},"PeriodicalIF":0.9,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74058355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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