Growth Hormone-Releasing Hormone as Potential Diagnostic and Therapeutic Target in Colorectal Cancer

S. Mehrabadi, Azam Alinaghipour, Ghazaleh Khalili-tanha, Amir Avan
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Abstract

As the third most prevalent cancer, there is no convincing treatment for colorectal cancer. Growth Hormone-releasing Hormone (GHRH) is an important hormone for the growth and maturity of humans and other animals. Also, recent studies show both GHRH and GHRH receptor to be expressed in many types of cancers, such as lung, breast, colon, ovarian, gastric, and pancreatic cancer. GHRH has been shown to augment the growth and proliferation of cancer cells in in vivo and in vitro studies, but studies have shown that its antagonist can inhibit the growth or even metastasis of cancer cells. The development of many classes of GHRH-R antagonists over the past three decades has shown strong in vivo and in vitro growth inhibitory effects on cancer. The present study is an attempt to review the studies on the association between GHRH and colorectal cancer and examine if the hormone can be targeted for therapy or used as a prognostic marker for colorectal cancer or not.
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作为结直肠癌潜在诊断和治疗靶点的生长激素释放激素
生长激素释放激素(GHRH)是人类和其他动物生长和成熟的重要激素。最近的研究表明,GHRH 和 GHRH 受体在肺癌、乳腺癌、结肠癌、卵巢癌、胃癌和胰腺癌等多种癌症中均有表达。在过去的三十年中,GHRH-R拮抗剂在体内和体外对癌细胞的生长有很强的抑制作用。本研究试图回顾有关 GHRH 与结直肠癌关系的研究,并探讨该激素是否可作为治疗靶点或结直肠癌预后标志物。
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