Multiple Bccs after Lisinopril Intake – Significant Connections to The Drug Related Photo- (Nitroso)-Carcinogenesis in The Context of Oncopharmacogenesis

Kordeva S, Parambi S, Ivanov L, Khanom S, Tchernev G
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Abstract

An 80-year-old female presented to the dermatology department due to an atrophic lesion in the area of the nasal apex, dating for the past 5-6 years. Moreover, there was a slowly developing tumor-like growth in her left temporal region, initially noticed 1-2 years ago. Over the last month, the formation began to bleed upon light touch. Furthermore, there was another lesion in the sacral area with an irregular hyperpigmented edge, also dating back 1-2 years. The patient denied having any allergies or family history of skin malignancies. Regarding comorbidities, she underwent cholecystectomy in 2016. She has been managing arterial hypertension with lisinopril dehydrate 10 mg once daily for the past 10 years. Additionally, she has been treating vertigo with a daily intake of betahistine dihydrochloride 16 mg for the same duration. She is also taking spironolactone 25 mg once daily at noon and diosmin 600 mg once daily at noon both for the past two months (prior to the consultation). The patient presented with a request for physical evaluation of the lesions and further therapeutic approach to be established.
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摄入利辛普利后出现多种 Bccs - 在肿瘤发生的背景下与药物相关的光(亚硝基)致癌作用密切相关
一位 80 岁的女性因鼻尖部位的萎缩性病变到皮肤科就诊,病程已有 5-6 年。此外,她的左颞部有一个缓慢发展的肿瘤样增生,最初在 1-2 年前发现。在过去的一个月里,该肿瘤开始在轻触时出血。此外,在骶骨部位还有另一个病变,边缘有不规则的色素沉着,也是在 1-2 年前发现的。患者否认有任何过敏史或皮肤恶性肿瘤家族史。关于合并症,她于 2016 年接受了胆囊切除术。在过去的 10 年中,她一直在使用 10 毫克脱水利辛普利治疗动脉高血压,每天一次。此外,她每天服用盐酸倍他司汀 16 毫克治疗眩晕,持续时间相同。在过去的两个月里(就诊前),她还在服用螺内酯 25 毫克,每天中午一次,以及地奥司明 600 毫克,每天中午一次。患者要求对病变部位进行物理评估,并确定进一步的治疗方法。
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