Comparative Study on the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) and Albumin Gel (ALB-Gel) in Facial Rejuvenation: A Clinical Ultrasonographic Evaluation

Abstract

Cutaneous ageing is a natural process associated with advancing age, potentially resulting in negative consequences on individuals' self-esteem. The primary manifestations of this process are the emergence of wrinkles, spots, dehydration, sagging, and loss of tissue vitality. In recent years, there has been a significant increase in the pursuit of more natural treatments for facial rejuvenation. In this context, using ALB-Gel and i-PRF stands out as a biological and autologous material. Materials and Methods: The measurement of the dermis using a 16 MHz ultrasound device and photographic documentation allowed for evaluating the technique's efficacy in reducing signs of ageing and nasolabial fold depth. The clinical study was conducted with 13 female participants aged 35 to 55 who underwent a session of ALB-Gel and i-PRF application in the right hemiface nasolabial fold region and i-PRF in the left hemiface. A paired t-test with a significance level of 5% was used in the statistical analysis. The scores on the Self-Perception Index were also statistically assessed using the Wilcoxon test at 5% to verify significant improvement. Additionally, new frontal and profile D and E photos were taken and compared with the initial images. Results: For the right hemiface nasolabial fold, a P < 0.0074 was observed to compare initial and final signs; for the left hemiface, a P < 0.1259 was obtained. These statistical results evidence a significant increase in dermal thickness in the right hemiface nasolabial fold (D) region after intradermal application of ALB-Gel and i-PRF; in the left hemiface nasolabial fold (E) region, treated only with i-PRF, no significant change in dermal thickness was observed. The statistical analysis conducted for the Self-Perception Index revealed a P < 0.0001, indicating a highly significant improvement in participant perception post-treatment. Conclusion: The intradermal application of ALB-Gel and i-PRF in a single session significantly increased dermal thickness, indicating this is a simple and low-cost alternative for dermal restructuring.