{"title":"Do vitamin D levels affect forced expiratory flow 25-75 among children with asthma?","authors":"Veena Anand, S. Joseph, I. Yadev","doi":"10.4038/sljch.v53i1.10706","DOIUrl":null,"url":null,"abstract":"Background: Previous reports of association between vitamin D levels and pulmonary function based on forced expiratory volume in one second (FEV1) and ratio of FEV1 to forced vital capacity (FEV1/FVC) gave mixed results. Forced expiratory flow 25-75 (FEF 25-75) is considered a sensitive parameter in children as it is effort independent.Objectives: To assess the correlation between serum vitamin D levels and pulmonary function parameters in children with asthma.Method: This cross-sectional analytic study was conducted at the paediatric respiratory clinic of a tertiary care referral hospital. Children aged 6-12 years, having asthma, on controllers with good compliance and under regular follow-up were enrolled.Results: Mean serum vitamin D level (16.8± 6.69ng/ml) was low and deficiency was seen in 36 (72%) children with asthma. Positive correlation (r=0.41) was seen between serum vitamin D levels and predicted FEF 25-75%. Univariate analysis between vitamin D and FEF 25-75 showed decreased vitamin D levels were associated with significantly low FEF 25-75 (p<0.001). In multivariate linear regression analysis after adjustment for age and sex, the relationship was direct and significant (R2=0.18, p<0.05) but for FEV1 the relationship was not significant (R2=-0.034, p=0.336).Conclusions: Vitamin D levels showed direct and significant relationship with FEF 25-75 outcome in children with asthma.","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":"17 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sri Lanka Journal of Child Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4038/sljch.v53i1.10706","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Previous reports of association between vitamin D levels and pulmonary function based on forced expiratory volume in one second (FEV1) and ratio of FEV1 to forced vital capacity (FEV1/FVC) gave mixed results. Forced expiratory flow 25-75 (FEF 25-75) is considered a sensitive parameter in children as it is effort independent.Objectives: To assess the correlation between serum vitamin D levels and pulmonary function parameters in children with asthma.Method: This cross-sectional analytic study was conducted at the paediatric respiratory clinic of a tertiary care referral hospital. Children aged 6-12 years, having asthma, on controllers with good compliance and under regular follow-up were enrolled.Results: Mean serum vitamin D level (16.8± 6.69ng/ml) was low and deficiency was seen in 36 (72%) children with asthma. Positive correlation (r=0.41) was seen between serum vitamin D levels and predicted FEF 25-75%. Univariate analysis between vitamin D and FEF 25-75 showed decreased vitamin D levels were associated with significantly low FEF 25-75 (p<0.001). In multivariate linear regression analysis after adjustment for age and sex, the relationship was direct and significant (R2=0.18, p<0.05) but for FEV1 the relationship was not significant (R2=-0.034, p=0.336).Conclusions: Vitamin D levels showed direct and significant relationship with FEF 25-75 outcome in children with asthma.
期刊介绍:
This is the only journal of child health in Sri Lanka. It is designed to publish original research articles and scholarly articles by recognized authorities on paediatric subjects. It is distributed widely in Sri Lanka and bears the ISSN number 1391-5452 for the print issues and e-ISSN 2386-110x for the electronic version in the internet. The journal is published quarterly and the articles are reviewed by both local and foreign peers. The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka.