Xiang Yuan , Zhen Sun , Jingqi Wu , Lijian Hui , Ludi Zhang
{"title":"Cell therapy for liver diseases: From hepatocyte transplantation to bioartificial livers","authors":"Xiang Yuan , Zhen Sun , Jingqi Wu , Lijian Hui , Ludi Zhang","doi":"10.1016/j.cobme.2024.100530","DOIUrl":null,"url":null,"abstract":"<div><p>Liver cell therapy presents a promising alternative to liver transplantation for patients with liver failure and hereditary liver diseases. However, its clinical implementation is limited largely due to the scarcity of human hepatocytes. Here, we review strategies to generate functional human hepatocytes with a mature phenotype and liver repopulation capability and highlight their potential clinical applications in hepatocyte transplantation and bioartificial liver transplantation. We summarize new delivery methods to improve hepatocyte engraftment, such as patch grafting and ectopic transplantation, and discuss potential future directions.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"30 ","pages":"Article 100530"},"PeriodicalIF":4.7000,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468451124000102","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
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Abstract
Liver cell therapy presents a promising alternative to liver transplantation for patients with liver failure and hereditary liver diseases. However, its clinical implementation is limited largely due to the scarcity of human hepatocytes. Here, we review strategies to generate functional human hepatocytes with a mature phenotype and liver repopulation capability and highlight their potential clinical applications in hepatocyte transplantation and bioartificial liver transplantation. We summarize new delivery methods to improve hepatocyte engraftment, such as patch grafting and ectopic transplantation, and discuss potential future directions.
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