Regenerative rehabilitation measures to restore tissue function after arsenic exposure

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2024-03-11 DOI:10.1016/j.cobme.2024.100529

Adam A. Jasper , Kush H. Shah , Helmet Karim , Swathi Gujral , Iva Miljkovic , Caterina Rosano , Aaron Barchowsky , Amrita Sahu

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Abstract

Environmental exposure of arsenic impairs the cardiometabolic profile, skeletal muscle health, and neurological function. Such declining tissue health is observed as early as in one's childhood, where the exposure is prevalent, thereby accelerating the effect of time's arrow. Despite the known deleterious effects of arsenic exposure, there is a paucity of specific treatment plans for restoring tissue function in exposed individuals. In this review, we propose to harness the untapped potential of existing regenerative rehabilitation programs, such as stem cell therapeutics with rehabilitation, acellular therapeutics, and artificial intelligence/robotics technologies, to address this critical gap in environmental toxicology. With regenerative rehabilitation techniques showing promise in other injury paradigms, fostering collaboration between these scientific realms offers an effective means of mitigating the detrimental effects of arsenic on tissue function.

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砷暴露后恢复组织功能的再生康复措施

环境中的砷会损害心脏代谢、骨骼肌健康和神经功能。这种组织健康状况的下降早在童年时期就可观察到，因为童年时期是接触砷的普遍时期，从而加速了时间之箭的效果。尽管已知砷暴露会产生有害影响，但目前还缺乏恢复砷暴露者组织功能的具体治疗方案。在这篇综述中，我们建议利用现有再生康复计划尚未开发的潜力，如干细胞疗法与康复、细胞疗法和人工智能/机器人技术，来解决环境毒理学中的这一关键缺口。随着再生康复技术在其他损伤范例中显示出前景，促进这些科学领域之间的合作为减轻砷对组织功能的有害影响提供了有效手段。

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来源期刊

Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

8.60

自引率

2.60%

发文量