Características sociodemográficas, clínicas y bioquímicas de pacientes que debutaron con y sin nefritis lúpica en una cohorte de pacientes mexicanos con lupus eritematoso sistémico en un centro de referencia

Abstract

Introduction

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that presents great clinical heterogeneity, so that up to 60% of patients may develop lupus nephropathy (LN).

Objective

To identify demographic, clinical, and biochemical characteristics of patients presenting with and without lupus nephritis at the time of SLE diagnosis in a cohort of Mexican patients.

Materials and methods

This is a cross-sectional, analytical, and single-centre study. Frequencies and percentages were used for categorical variables and the comparison was made with Pearson's Chi2 statistical test or Fisher's exact test. For the quantitative variables, their distribution was calculated and according to this, Student's t was used in case of normal distribution and Mann-Whitney U for those with free distribution.

Results

Of 160 patients, 79 (49.37%) had LN. These individuals had a higher prevalence of serositis (14.3 vs 8.1%, p = .048) and arterial hypertension (40.50% vs 24.6%, p = .033), while those without LN had a higher prevalence of rheumatoid arthritis and joint disease (6 vs 1%, p = .052), allergies (43.2 vs 20.25%, p = .002), infections (23.45 vs 10%, p = .020), and lower levels of C3 (52.25 ± 28.7 vs 74.6 ± 32.2 mg/dl, p < .001).

Conclusions

The characteristics described in our cohort are like those presented in other Latino and Asian series. However, the presence of concomitant infections at the time of SLE diagnosis has not been described and should be considered for future research.