Gut pathobiome mediates behavioral and developmental disorders in biotoxin-exposed amphibians

IF 14 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Science and Ecotechnology Pub Date : 2024-03-21 DOI:10.1016/j.ese.2024.100415
Qianqian Pan , Tianxing Lv , Haorong Xu , Hongda Fang , Meng Li , Jiaping Zhu , Yue Wang , Xiaoyan Fan , Ping Xu , Xiuguo Wang , Qiangwei Wang , Haruna Matsumoto , Mengcen Wang
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Abstract

Emerging evidence suggests a link between alterations in the gut microbiome and adverse health outcomes in the hosts exposed to environmental pollutants. Yet, the causal relationships and underlying mechanisms remain largely undefined. Here we show that exposure to biotoxins can affect gut pathobiome assembly in amphibians, which in turn triggers the toxicity of exogenous pollutants. We used Xenopus laevis as a model in this study. Tadpoles exposed to tropolone demonstrated notable developmental impairments and increased locomotor activity, with a reduction in total length by 4.37%–22.48% and an increase in swimming speed by 49.96%–84.83%. Fusobacterium and Cetobacterium are predominant taxa in the gut pathobiome of tropolone-exposed tadpoles. The tropolone-induced developmental and behavioral disorders in the host were mediated by assembly of the gut pathobiome, leading to transcriptome reprogramming. This study not only advances our understanding of the intricate interactions between environmental pollutants, the gut pathobiome, and host health but also emphasizes the potential of the gut pathobiome in mediating the toxicological effects of environmental contaminants.

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肠道病原生物群介导暴露于生物毒素的两栖动物的行为和发育障碍
新的证据表明,肠道微生物组的改变与暴露于环境污染物的宿主的不良健康结果之间存在联系。然而,其中的因果关系和内在机制在很大程度上仍未确定。在这里,我们发现暴露于生物毒素会影响两栖动物肠道病原生物群的组合,进而引发外源污染物的毒性。在这项研究中,我们使用爪蟾作为模型。暴露于他洛波龙的蝌蚪表现出明显的发育障碍和运动活动增加,总长度减少了4.37%-22.48%,游泳速度增加了49.96%-84.83%。Fusobacterium和Cetobacterium是暴露于tropolone的蝌蚪肠道病原生物群中的主要分类群。肠道病原生物群的集合导致转录组的重编程,从而介导了宿主的发育和行为紊乱。这项研究不仅加深了我们对环境污染物、肠道病原生物群和宿主健康之间错综复杂的相互作用的理解,还强调了肠道病原生物群在介导环境污染物毒理效应方面的潜力。
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来源期刊
CiteScore
20.40
自引率
6.30%
发文量
11
审稿时长
18 days
期刊介绍: Environmental Science & Ecotechnology (ESE) is an international, open-access journal publishing original research in environmental science, engineering, ecotechnology, and related fields. Authors publishing in ESE can immediately, permanently, and freely share their work. They have license options and retain copyright. Published by Elsevier, ESE is co-organized by the Chinese Society for Environmental Sciences, Harbin Institute of Technology, and the Chinese Research Academy of Environmental Sciences, under the supervision of the China Association for Science and Technology.
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