Environmental Science and Ecotechnology最新文献

Nanoplastics amplify 6PPD ocular toxicity in zebrafish 纳米塑料增强斑马鱼的6PPD眼毒性

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2026.100657

Jian Lin , Dongliang Pan , Xingxing Chen , Minyan Xu , Yangfan Zhu , Yi Zheng , Yang Song , Jiangfei Chen

Nanoplastics and tire-derived chemicals are ubiquitous co-pollutants in aquatic environments, originating from road runoff and posing potential risks to vertebrate development through enhanced bioavailability and synergistic toxicity. Polystyrene nanoplastics (PS) can adsorb hydrophobic organics like the antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), acting as vectors that increase tissue accumulation and exacerbate oxidative stress, while 6PPD alone disrupts mitochondrial function and induces sublethal effects in exposed organisms. The vertebrate eye, with its direct environmental exposure and sensitive neural structures, is particularly vulnerable, yet the combined impact of PS and 6PPD on visual morphogenesis remains underexplored. Here we show that co-exposure to environmentally relevant concentrations of PS (1 mg L⁻¹) and 6PPD (0.1–0.8 mg L⁻¹) markedly potentiates ocular toxicity compared to individual exposures, manifesting as myopia-like malformations, increased cell death, and impaired phototaxis. We integrated phenotypic, histological, and multi-omics analyses using zebrafish embryos as a model. Our results show PS-enhanced bioaccumulation of 6PPD in ocular tissues, leading to severe lens and retinal damage, aberrant vascularization, disrupted myelination, and dysregulated pathways including serine proteolysis, retinoic acid metabolism, and ferroptosis-linked oxidative stress. These findings demonstrate nanoplastic-chemical interactions as an emerging threat to aquatic visual function, with implications for survival behaviors and broader ecosystem health under pervasive pollution.

纳米塑料和轮胎衍生化学品是水生环境中普遍存在的共污染物，源于道路径流，并通过增强生物利用度和协同毒性对脊椎动物发育构成潜在风险。聚苯乙烯纳米塑料（PS）可以吸附疏水有机物，如抗氧化剂N-（1,3-二甲基丁基）-N'-苯基-对苯二胺（6PPD），作为增加组织积累和加剧氧化应激的载体，而6PPD单独破坏线粒体功能，并在暴露的生物体中诱发亚致死效应。脊椎动物的眼睛，由于其直接的环境暴露和敏感的神经结构，特别容易受到伤害，但PS和6PPD对视觉形态发生的联合影响仍未得到充分的研究。本研究表明，与单独暴露相比，暴露于环境相关浓度的PS （1mg L−1）和6PPD （0.1-0.8 mg L−1）可显著增强眼毒性，表现为近视样畸形、细胞死亡增加和趋光性受损。我们以斑马鱼胚胎为模型，进行了表型、组织学和多组学分析。我们的研究结果表明，ps增强了6PPD在眼组织中的生物积累，导致严重的晶状体和视网膜损伤，血管形成异常，髓鞘形成中断，丝氨酸蛋白水解，视黄酸代谢和铁中毒相关氧化应激等途径失调。这些发现表明，纳米塑料-化学相互作用是对水生生物视觉功能的新威胁，对普遍污染下的生存行为和更广泛的生态系统健康具有影响。

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引用次数: 0

OVOCs drive radical cycling and ozone formation in background air OVOCs驱动本底空气中的自由基循环和臭氧形成

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2026.100659

Enyu Xiong , Hai Guo , Tzung-May Fu , Xiaopu Lyu , Yu Wang , Beining Zhou , Men Xia , Zhouxing Zou , Qi Yuan , Jin Yang , Kit Ying Shek , Jiongkai Chen , Tianci Jiang , Wei Tao , Aoxing Zhang , Wang Xiang , Shuncheng Lee , Tao Wang

Surface ozone pollution is a critical global environmental challenge driven by the complex, nonlinear photochemical cycling of RO_x radicals (OH + HO₂ + RO₂). Oxygenated volatile organic compounds (OVOCs) are central to these cycles as both radical sources and sinks, yet their quantitative impact on regional radical budgets remains poorly understood due to historical limitations in ambient measurements. This knowledge gap hinders the accurate prediction of persistent ozone exceedances. Here we show that constraining atmospheric models with a broad suite of 23 OVOCs—specifically reactive dicarbonyls—is essential for the accurate simulation of radical chemistry in southern China's background air through comprehensive field observations and photochemical modeling. We find that models constrained with only the three most common OVOCs (formaldehyde, acetaldehyde, and acetone) overestimate hydroxyl radical concentrations by 50 %–100 %, whereas comprehensive constraints align simulations with observations. This discrepancy is caused by complex offsetting errors, including the severe overestimation of isoprene-derived intermediates and the significant underestimation of secondary biacetyl production. Our results reveal that photolysis of the measured OVOCs contributes 49 %–61 % of total RO_x production, with species such as methylglyoxal and biacetyl playing unexpectedly dominant roles in driving ozone formation. These findings highlight critical deficiencies in current chemical mechanisms and demonstrate that high-resolution monitoring of reactive OVOC intermediates is vital for developing effective emission control strategies to mitigate persistent regional ozone pollution.

表面臭氧污染是由ROx自由基（OH + HO2 + RO2）复杂的非线性光化学循环驱动的重大全球环境挑战。含氧挥发性有机化合物（OVOCs）是这些循环的核心，既是自由基的来源，也是自由基的汇，但由于环境测量的历史限制，它们对区域自由基预算的定量影响仍然知之甚少。这种知识差距妨碍了对持续臭氧超标的准确预测。本文表明，通过全面的野外观测和光化学模拟，具有广泛的23种挥发性有机化合物（特别是活性二羰基）的约束大气模型对于准确模拟中国南方背景空气中的自由基化学至关重要。我们发现，仅受三种最常见的挥发性有机化合物（甲醛、乙醛和丙酮）约束的模型高估了羟基自由基浓度50% - 100%，而综合约束使模拟与观测结果一致。这种差异是由复杂的抵消误差造成的，包括对异戊二烯衍生中间体的严重高估和对二次双乙酰生成的严重低估。我们的研究结果表明，测量的OVOCs光解作用贡献了总ROx产量的49% - 61%，其中甲基乙二醛和双乙酰等物质在驱动臭氧形成中起着意想不到的主导作用。这些发现突出了当前化学机制的关键缺陷，并表明对活性OVOC中间体的高分辨率监测对于制定有效的排放控制策略以减轻持续的区域臭氧污染至关重要。

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引用次数: 0

Iron redox cycling drives enhanced methanogenesis in magnetic biochar-mediated anaerobic digestion of waste-activated sludge 铁氧化还原循环驱动磁性生物炭介导的废物活性污泥厌氧消化中强化的甲烷生成

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2026.100660

Qing-Bin Meng , Zhang-Wei He , Zhi-Hua Li , Cong-Cong Tang , Ai-Juan Zhou , Bin Liang , Wenzong Liu , Yong-Xiang Ren , Aijie Wang

Anaerobic digestion provides an essential pathway for reducing organic waste while simultaneously recovering bioenergy. To enhance this process, magnetic biochars are frequently employed as conductive additives to promote direct interspecies electron transfer (DIET) among syntrophic microorganisms. However, the fundamental mechanisms regarding how iron species leached from these materials influence iron transformation and electron flux remain poorly understood. Here we show that the leaching of iron species from magnetic biochar establishes a stable Fe(III)/Fe(II) redox cycle that accelerates the hydrolysis, acidogenesis, and methanogenesis of waste-activated sludge. We find that cumulative methane production increases by 17 % as leached Fe(III) facilitates dissimilatory iron reduction, followed by secondary mineralization into high-crystalline iron species. This process selectively enriches electroactive taxa, including Geobacter and Methanothrix, and transitioned the dominant electron transfer mechanism from cytochrome c-dependent pathways to a Fe(III)/Fe(II) redox-driven DIET. These mechanisms advance our understanding of conductive material-mediated AD, offering strategies to optimize energy recovery from waste-activated sludge and support sustainable sludge management in wastewater treatment.

厌氧消化是减少有机废物同时回收生物能源的重要途径。为了加强这一过程，磁性生物炭经常被用作导电添加剂来促进合成微生物之间的直接种间电子转移（DIET）。然而，关于从这些材料中浸出的铁如何影响铁的转化和电子通量的基本机制仍然知之甚少。本研究表明，磁性生物炭中铁的浸出建立了一个稳定的铁(III)/铁（II）氧化还原循环，加速了废物活性污泥的水解、酸生成和甲烷生成。我们发现，由于浸出的Fe（III）促进了异化铁还原，然后二次矿化成高晶铁，累积甲烷产量增加了17%。这一过程选择性地丰富了电活性类群，包括Geobacter和Methanothrix，并将主要的电子传递机制从细胞色素c依赖途径转变为Fe(III)/Fe（II）氧化还原驱动的DIET。这些机制促进了我们对导电材料介导的AD的理解，为优化废物活性污泥的能量回收提供了策略，并支持废水处理中可持续的污泥管理。

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引用次数: 0

Weighted network analysis of adverse outcome pathways decodes the multiscale mechanisms of environmental toxicity 不良后果途径的加权网络分析解码了环境毒性的多尺度机制

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2026.100663

Huajie Yang , Kaiyi Zhang , Yue Wang , Shuailing Liu , Yinchu Guo , Wei Liu , Jiaxing Sun , Zhaoqi Zhang , Sen Zhang , Shenghang Li , Yingcheng Zhao , Tong Liu , Junhong Liu , Liang Pei , Shuhua Xi , Peng Shi

The rapid proliferation of synthetic chemicals has significantly outpaced traditional toxicity characterization, leaving a critical data gap in environmental health risk assessment. While the adverse outcome pathway (AOP) framework provides a mechanistic scaffold for organizing toxicity knowledge, it is currently limited by a focus on linear pathways and a bias toward well-studied endpoints. Conversely, the exposome paradigm captures broad environmental stressors but often lacks the mechanistic depth required for causal interpretation. A fundamental challenge remains in developing integrative paradigms that can systematically bridge these multi-scale datasets to decode complex, chemical-induced diseases. Here we show that AOP-ExpoVis, an integrative computational platform, synergizes exposome-disease networks with AOP ontologies to prioritize pathogenic mechanisms through a weighted phenotype-disease scoring algorithm. By integrating chemical, gene, phenotype, and disease associations, the platform identifies key phenotypes and maps them to curated pathways to generate testable mechanistic hypotheses. Validation across three distinct case studies involving 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), arsenic, and perfluoroalkyl substances (PFAS) demonstrated that AOP-ExpoVis accurately identifies both conserved and chemical-specific toxic pathways, such as aryl hydrocarbon receptor activation and lipid metabolism disruption. AOP-ExpoVis provides an open-source tool for rapid mechanistic inference that overcomes the limitations of traditional, single-pathway frameworks. This work advances predictive toxicology by enabling the systematic prioritization of chemical hazards and the refinement of regulatory risk assessment in a data-rich environment.

合成化学品的迅速扩散大大超过了传统的毒性表征，在环境健康风险评估方面留下了严重的数据缺口。虽然不良结果途径（AOP）框架为组织毒性知识提供了一个机制框架，但它目前受到对线性途径的关注和对充分研究的终点的偏见的限制。相反，暴露范式捕获了广泛的环境压力源，但往往缺乏因果解释所需的机制深度。一个根本的挑战仍然是开发综合范例，可以系统地连接这些多尺度数据集，以解码复杂的化学诱导疾病。在这里，我们展示了AOP- expovis，一个综合计算平台，通过加权表型-疾病评分算法将暴露体-疾病网络与AOP本体协同起来，优先考虑致病机制。通过整合化学、基因、表型和疾病关联，该平台确定了关键表型，并将其映射到精心策划的途径中，以生成可测试的机制假设。涉及2,2 ',4,4 ' -四溴联苯醚（BDE-47），砷和全氟烷基物质（PFAS）的三个不同案例研究的验证表明，AOP-ExpoVis准确识别保守和化学特异性毒性途径，如芳烃受体激活和脂质代谢破坏。AOP-ExpoVis提供了一个用于快速机制推理的开源工具，克服了传统的单路径框架的局限性。这项工作通过在数据丰富的环境中系统地确定化学危害的优先次序和改进监管风险评估来推进预测毒理学。

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引用次数: 0

Quasi-MOFs in water treatment: Synthesis, characterization, and applications 水处理中的准mof：合成、表征及应用

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2025.100650

Xin-Jie Li , Fei Wang , Yuliang Dong , Shih-Hsin Ho , Chong-Chen Wang

Metal-organic frameworks (MOFs) are widely investigated for water purification, yet conventional materials are often limited by saturated metal nodes that restrict active-site accessibility and by microporous channels that impede mass transport. Defect engineering provides a means to generate unsaturated metal sites and hierarchical porosity while preserving framework integrity. Quasi-MOFs occupy a distinct position within this landscape, retaining partial long-range order and local coordination environments of the parent MOF while incorporating controlled defects that yield high densities of coordinatively unsaturated sites and multimodal pore structures. In this review, we summarize synthetic strategies that enable precise control of defect type, density, and distribution in quasi-MOFs, including thermal activation, post-synthetic ligand exchange, and modulated coordination approaches. We examine advanced characterization techniques that reveal correlations between engineered defects and enhanced pollutant diffusion and catalytic activation. Applications in adsorptive removal and advanced oxidation/reduction processes are analyzed, highlighting performance advantages derived from improved site accessibility and transport kinetics relative to pristine MOFs. Finally, we discuss persisting challenges, including hydrolytic stability, scalable synthesis, and detailed structure-activity relationships, and outline future directions for translating quasi-MOFs into practical water-treatment technologies.

金属有机框架（mof）在水净化方面得到了广泛的研究，但传统材料往往受到饱和金属节点的限制，这些节点限制了活性位点的可及性，并且微孔通道阻碍了物质的运输。缺陷工程提供了一种在保持框架完整性的同时生成不饱和金属位点和分层孔隙的方法。准MOF在这一景观中占据着独特的位置，保留了母体MOF的部分远程秩序和局部协调环境，同时结合了产生高密度协调不饱和位点和多模态孔隙结构的受控缺陷。在这篇综述中，我们总结了能够精确控制准mof中缺陷类型、密度和分布的合成策略，包括热活化、合成后配体交换和调制配位方法。我们研究了先进的表征技术，揭示了工程缺陷与增强的污染物扩散和催化活化之间的相关性。分析了mof在吸附去除和高级氧化/还原过程中的应用，强调了与原始mof相比，mof在改善位点可达性和运输动力学方面的性能优势。最后，我们讨论了持续存在的挑战，包括水解稳定性、可扩展合成和详细的构效关系，并概述了将准mof转化为实际水处理技术的未来方向。

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引用次数: 0

From elastic thresholds to predictive management: Advancing freshwater ecosystem conservation 从弹性阈值到预测性管理：推进淡水生态系统保护

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2025.100655

Huiyu Xie , Xiaowei Jin , Aibin Zhan , Xianfu Zhao , Andrew C. Jonson , Fengchang Wu

引用次数: 0

Systemic risks and cascading dynamics in the global cobalt supply chain 全球钴供应链的系统性风险和级联动态

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2025.100654

Xin Ouyang , Litao Liu , Qiance Liu , Wu Chen , Chao Wang , Xun Pang , Canfei He , Gang Liu

The global transition to low-carbon technologies hinges on secure supplies of critical minerals like cobalt, yet interconnected supply chains are increasingly vulnerable to geopolitical tensions and frequent external disruptions. Existing risk assessments often treat commodities in isolation, overlooking the upstream–downstream dependencies that amplify cascading failures. Here we show systemic risks in global cobalt flows from 1998 to 2019 across 230 countries and regions by integrating trade-linked material flow analysis with a multilayer shock propagation model. Our results reveal that disruptions propagate through alternating horizontal–vertical and direct–indirect pathways, with risk concentrating at the mining stage but accumulating predominantly in refining–manufacturing bridges. These cascades yield abrupt nonlinear failures and an avalanche network four times denser than the underlying physical supply chain. Nations with low systemic fragility but high exposure rate—such as Indonesia, South Africa, and Mexico—are particularly susceptible to common random disruptions and lack resilience or effective response. Over the past two decades, global systemic risks have followed a volatile but upward trend. These findings highlight that national mitigation strategies are necessary but insufficient; achieving resilience requires stage-aware, system-level coordination and multilateral cooperation.

全球向低碳技术的转型取决于钴等关键矿物的安全供应，但相互关联的供应链越来越容易受到地缘政治紧张局势和频繁外部干扰的影响。现有的风险评估通常孤立地对待商品，忽略了放大级联故障的上下游依赖关系。本文通过将与贸易相关的物料流分析与多层冲击传播模型相结合，展示了1998年至2019年230个国家和地区全球钴流的系统性风险。我们的研究结果表明，破坏通过水平-垂直和直接-间接交替的途径传播，风险集中在采矿阶段，但主要积聚在精炼-制造桥梁中。这些级联产生突然的非线性故障和雪崩网络，其密度是底层物理供应链的四倍。系统脆弱性低但暴露率高的国家，如印度尼西亚、南非和墨西哥，特别容易受到常见的随机破坏的影响，缺乏弹性或有效的应对措施。在过去的二十年中，全球系统性风险遵循了一个波动但上升的趋势。这些发现突出表明，国家缓解战略是必要的，但还不够；实现复原力需要有阶段意识的系统级协调和多边合作。

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引用次数: 0

Ultrahigh-resolution 3D monitoring reveals sediment-derived plumes as algal bloom precursors 超高分辨率3D监测显示，沉积物衍生的羽流是藻华的前兆

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2025.100652

Peng Xiao , Congchao Zhang , Yu Tao , Tiefu Xu , Ying Chen , Lian Feng , Lingchao Kong , Zhidan Wen , Weibin Zheng , Hao Xu , Longxin Guo , Hangyu Guo , Zheng Pang , Zhiling Li , Chuan He , Shujie Xu , Kaishan Song , Jie Feng , Zhugen Yang , Shu-Chien Hsu , Nanqi Ren

The global intensification of harmful algal blooms severely compromises freshwater ecosystems, threatening biodiversity and critical ecosystem services through toxin exposure, hypoxia, and water quality degradation. Bloom formation involves a complex interplay of nutrient dynamics, hydrology, and microbial activity. Although subsurface processes—such as the release of sediment-bound nutrients and the germination of dormant cyanobacteria—are thought crucial to bloom initiation, these phenomena occur at fine spatiotemporal scales beyond the reach of conventional monitoring. As a result, the exact, rapidly evolving triggers of bloom emergence remain mostly unknown. Here we show meter-scale chlorophyll a (Chl-a) plumes rising from the sediment–water interface, triggered by heavy rainfall and directly seeding surface blooms. We captured these dynamics using a custom underwater drone that collected over 2.8 million data points at 5-m horizontal and 1-m vertical resolution. Algal blooms exhibit a clear vertical sequence: anomalous Chl-a levels first appear in deep benthic layers after rainfall-driven resuspension, then intensify simultaneously across near-bed depths, and finally reach the surface after a median lag of 0.8–1.5 days. These observations provide in situ evidence associating benthic algal seed stocks with surface bloom initiation, revealing that the origin and spatial heterogeneity of such events arise from rainfall-driven disturbances at the sediment–water interface. This robotic approach not only deciphers the subsurface origins of algal blooms but also empowers predictive modeling and adaptive management strategies, advancing global efforts to combat eutrophication amid escalating climate pressures and safeguard vital water resources.

有害藻华的全球加剧严重损害了淡水生态系统，通过毒素暴露、缺氧和水质退化威胁生物多样性和关键的生态系统服务。水华的形成涉及营养动态、水文和微生物活动的复杂相互作用。虽然地下过程——如沉积物结合的养分的释放和休眠蓝藻的萌发——被认为对水华的开始至关重要，但这些现象发生在精细的时空尺度上，超出了传统监测的范围。因此，确切的、快速进化的水华出现的触发因素在很大程度上仍然未知。在这里，我们展示了米尺度的叶绿素a （Chl-a）羽流从沉积物-水界面上升，由强降雨和直接种子表面华花引发。我们使用定制的水下无人机捕获了这些动态，该无人机以5米水平和1米垂直分辨率收集了超过280万个数据点。藻华表现出明显的垂直序列：在降雨驱动的再悬浮后，异常的Chl-a水平首先出现在深底栖层，然后在近河床深度同时加剧，最后在0.8-1.5天的中位滞后后到达地表。这些观测结果提供了将底栖藻类种子库与地表水华发生联系起来的原位证据，揭示了这类事件的起源和空间异质性源于降雨驱动的沉积物-水界面扰动。这种机器人方法不仅可以破译藻华的地下起源，还可以增强预测建模和适应性管理策略，在气候压力不断上升的情况下推进全球对抗富营养化的努力，并保护重要的水资源。

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引用次数: 0

Citizen science powers wetland restoration 公民科学助力湿地恢复

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2026.100656

Shihao Cui , Haonan Guo , Lorenzo Pugliese , Gitte Kragh , Sonia Mena , Shubiao Wu

Wetlands provide essential ecosystem services, from carbon sequestration and flood mitigation to biodiversity support, yet over 20 % have been lost in recent centuries, prompting global restoration efforts backed by policies like the UN Decade on Ecosystem Restoration. Despite rapid expansion of restoration projects, conventional monitoring remains short-term, expert-driven, and often disconnected from site-specific ecological dynamics, limiting adaptive management and long-term success. Citizen science has revolutionized ecological monitoring in other domains by enabling scalable, participatory data collection, but its application to wetland restoration has been largely overlooked. In this Perspective, we assess 120 restoration project sites worldwide and find that citizen science is currently integrated into fewer than 20 % of projects even in high-activity regions like Europe, leaving significant social and geographic potential untapped. We find that recent advances in affordable remote sensing, miniaturized sensors, and mobile platforms—supported by rigorous data-validation frameworks—are now overcoming historical constraints regarding data reliability and spatial continuity. These technological shifts, when coupled with emerging institutional recognition, allow citizen-generated data to serve as a scalable, cost-effective infrastructure for monitoring ecological change over meaningful timescales. Systematically integrating public participation into restoration practice is therefore essential for closing critical monitoring gaps and ensuring the long-term sustainability of global wetland ecosystems.

湿地提供了重要的生态系统服务，从碳封存和洪水缓解到生物多样性支持，但近几个世纪以来，湿地已经损失了20%以上，这促使全球在联合国生态系统恢复十年等政策的支持下进行恢复工作。尽管恢复项目迅速扩大，但传统的监测仍然是短期的、专家驱动的，往往与特定地点的生态动态脱节，限制了适应性管理和长期成功。公民科学通过实现可扩展的、参与式的数据收集，已经彻底改变了其他领域的生态监测，但它在湿地恢复中的应用在很大程度上被忽视了。从这个角度来看，我们评估了全球120个修复项目地点，发现即使在像欧洲这样的高活动地区，公民科学目前也只有不到20%的项目被纳入，留下了巨大的社会和地理潜力尚未开发。我们发现，在经济实惠的遥感、小型化传感器和移动平台方面的最新进展——由严格的数据验证框架支持——正在克服有关数据可靠性和空间连续性的历史限制。这些技术转变，再加上新兴的制度认可，使公民产生的数据成为一种可扩展的、具有成本效益的基础设施，用于在有意义的时间尺度上监测生态变化。因此，将公众参与系统地纳入恢复实践对于缩小关键的监测差距和确保全球湿地生态系统的长期可持续性至关重要。

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引用次数: 0

Ephedrine-disrupted synaptogenesis signaling and behavioral abnormalities in adult zebrafish 麻黄碱破坏成年斑马鱼突触发生信号和行为异常

IF 14.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Science and Ecotechnology

Pub Date : 2026-01-01 DOI: 10.1016/j.ese.2026.100661

Yanghui Deng , Xingxing Yin , Changsheng Guo , Wenhui Qiu , Meng Zhang , Xu Tan , Jian Xu

Ephedrine is a prevalent sympathomimetic alkaloid and amphetamine-type stimulant precursor that has become a widespread contaminant in global aquatic ecosystems. While the neurotoxic effects of high-dose ephedrine exposure are documented in humans and other mammals, its impact on aquatic vertebrates at environmentally realistic concentrations remains poorly understood. Determining how these persistent residues affect neural development and physiological homeostasis is critical for evaluating ecological risks to aquatic life. Here we show that chronic, low-dose ephedrine exposure impairs neurodevelopment in adult zebrafish by simultaneously disrupting synaptogenesis architecture and neurotransmitter balance. Integrated transcriptomic and histopathological analyses reveal that ephedrine targets the synaptogenesis signaling pathway, resulting in reduced presynaptic vesicles and structural abnormalities in the postsynaptic density. Computational docking and biochemical assays further demonstrate that ephedrine engages the vesicular acetylcholine transporter and tyrosine hydroxylase with high affinity, triggering excitotoxic cascades and biphasic neurochemical dysregulation that manifest as anxiety-like phenotypes and cognitive impairments. These findings indicate that environmentally relevant concentrations of stimulant precursors pose a significant threat to the neural circuit integrity of aquatic species, necessitating urgent regulatory attention to pharmaceutical residues in surface waters.

麻黄碱是一种普遍存在的拟交感生物碱和苯丙胺类兴奋剂前体，已成为全球水生生态系统中广泛存在的污染物。虽然高剂量麻黄碱暴露对人类和其他哺乳动物的神经毒性作用有文献记载，但其对水生脊椎动物在环境实际浓度下的影响仍知之甚少。确定这些持久性残留物如何影响神经发育和生理稳态对于评估水生生物的生态风险至关重要。本研究表明，慢性低剂量麻黄碱暴露会同时破坏突触发生结构和神经递质平衡，从而损害成年斑马鱼的神经发育。综合转录组学和组织病理学分析表明，麻黄碱靶向突触发生信号通路，导致突触前囊泡减少和突触后密度结构异常。计算对接和生化分析进一步表明，麻黄碱与囊泡乙酰胆碱转运体和酪氨酸羟化酶具有高亲和力，引发兴奋毒性级联反应和双相神经化学失调，表现为焦虑样表型和认知障碍。这些发现表明，环境相关浓度的兴奋剂前体对水生物种的神经回路完整性构成重大威胁，迫切需要对地表水中的药物残留进行监管。

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引用次数: 0