Associations between low-moderate prenatal alcohol exposure and brain development in childhood

IF 3.4 2区医学 Q2 NEUROIMAGING Neuroimage-Clinical Pub Date : 2024-01-01 DOI:10.1016/j.nicl.2024.103595

Deanne K. Thompson , Claire E. Kelly , Thijs Dhollander , Evelyne Muggli , Stephen Hearps , Sharon Lewis , Thi-Nhu-Ngoc Nguyen , Alicia Spittle , Elizabeth J. Elliott , Anthony Penington , Jane Halliday , Peter J. Anderson

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Abstract

Background

The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied.

Aim

To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE.

Methods

Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). T₁-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre density and cross-section (FDC) metrics were computed for diffusion images. Brain measures were compared between PAE groups adjusted for age and sex, then additionally for intracranial volume.

Results

After adjustments, the right caudal anterior cingulate cortex volume (p_FDR = 0.045) and area (p_FDR = 0.008), and right cingulum tract cross-sectional area (p_FWE < 0.05) were smaller in children exposed to alcohol throughout gestation compared with no PAE.

Conclusion

This study reports a relationship between low-moderate PAE throughout gestation and cingulate cortex and cingulum tract alterations, suggesting a teratogenic vulnerability. Further investigation is warranted.

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中低度产前酒精暴露与儿童期大脑发育的关系

背景中度产前酒精暴露（PAE）对大脑发育的影响鲜有研究。目的比较仅在妊娠三个月中有中度PAE、在整个妊娠期间有中度PAE或没有PAE的6至8岁儿童的大脑皮层和白质结构。对143名6至8岁的儿童进行了磁共振成像检查，这些儿童分别患有妊娠三个月中的PAE（44人）、妊娠期间的PAE（58人）和无PAE（41人）。使用 FreeSurfer 处理 T1 加权图像，获得每个半球 34 个皮质区域的脑容量、面积和厚度。对扩散图像计算纤维密度（FD）、纤维横截面（FC）和纤维密度与横截面（FDC）指标。结果经调整后，右尾前扣带回皮层体积（pFDR = 0.045）和面积（pFDR = 0.008）以及右侧扣带回束横截面积（pFWE < 0.结论本研究报告了整个妊娠期低-中度 PAE 与扣带回皮层和扣带回束改变之间的关系，表明存在致畸易感性。有必要进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.