Neuroimage-Clinical最新文献

Establishing the link between post-concussive symptoms and brain network dysfunction: A systematic scoping review of neuroimaging evidence. 建立脑震荡后症状与脑网络功能障碍之间的联系：神经影像学证据的系统范围审查。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-26 DOI: 10.1016/j.nicl.2026.103956

Caerwen S Ellery, André N Avila, Melissa G Papini, Melinda Fitzgerald, Sarah C Hellewell

Mild traumatic brain injury (mTBI) is a prevalent condition with symptoms spanning physical, psychological, cognitive, and sleep domains. Altered functional brain networks have been implicated in mTBI, but the relationship between these network changes and post-concussive symptoms remains poorly understood. This study is a systematic scoping review, adhering to PRISMA-ScR guidelines, assessing current literature on the association between brain network dysfunction and mTBI-related symptoms. Searches across ProQuest, Web of Science, and PubMed yielded 41 studies for full review, with most (n = 39) employing resting-state functional magnetic resonance imaging (rs-fMRI) to examine brain networks. The default mode network (DMN) was a primary focus, with studies reporting heterogeneous findings of increased and decreased connectivity both within and outside this network. Over 85% of studies used mTBI-specific symptom measures, and 50% employed detailed questionnaires for emotional and physical symptom assessment. Of these, 23 studies identified significant correlations between symptom scores and network connectivity. However, methodological inconsistencies, including variable analytic approaches, highlight the need for standardization in this field. Key areas for future research include incorporating multimodal imaging techniques, conducting longitudinal studies or extending recruitment time points, and stratifying analyses by sex to optimise identification of connectivity changes. Addressing these gaps is crucial for advancing our understanding of functional network alterations in mTBI and their clinical implications, ultimately supporting improved diagnostic and therapeutic strategies.

轻度创伤性脑损伤（mTBI）是一种常见的疾病，其症状跨越身体、心理、认知和睡眠领域。脑功能网络的改变与mTBI有关，但这些网络变化与脑震荡后症状之间的关系仍然知之甚少。本研究是一项系统的范围综述，遵循PRISMA-ScR指南，评估当前关于脑网络功能障碍与mtbi相关症状之间关系的文献。在ProQuest、Web of Science和PubMed上进行搜索，产生了41项研究供全面审查，其中大多数（n = 39）使用静息状态功能磁共振成像（rs-fMRI）来检查大脑网络。默认模式网络（DMN）是主要焦点，研究报告了该网络内外连接增加和减少的异质结果。超过85%的研究使用了mtbi特异性症状测量，50%的研究使用了详细的情绪和身体症状评估问卷。其中，23项研究确定了症状评分与网络连接之间的显著相关性。然而，方法上的不一致，包括变量分析方法，突出了这一领域标准化的必要性。未来研究的关键领域包括结合多模态成像技术，进行纵向研究或延长招募时间点，以及按性别分层分析以优化识别连通性变化。解决这些空白对于提高我们对mTBI中功能网络改变及其临床意义的理解至关重要，最终支持改进诊断和治疗策略。

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引用次数: 0

Individualized functionnectome for the statistical assessment of white matter circuits underlying task-fMRI activations in glioma patients 脑胶质瘤患者任务-功能磁共振成像激活下白质回路的个体化功能组统计评估。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103940

Giovanni Sighinolfi , Alexander Leemans , David Neil Manners , Elena Cantoni , Gianfranco Vornetti , Lorenzo Motta , Enrico Franceschi , Caterina Tonon , Raffaele Lodi , Alberto De Luca

The Functionnectome framework enables the projection of task-related fMRI signals onto the underlying white matter pathways, using anatomical priors derived from structural connectivity. However, the existing “standardized” priors are based on averaged tractograms from healthy controls and cannot accurately capture the altered anatomy found in patients with brain lesions.

This study extends the Functionnectome framework by generating individualized anatomical priors from subject-specific diffusion MRI tractography, allowing for improved integration of functional and structural data in patients with brain tumors. Twenty-six patients with gliomas (9 females; mean age 43 ± 17 years) underwent 3 T MRI, including a multishell diffusion protocol and task-based fMRI targeting motor and/or language functions. Whole-brain tractography was reconstructed using three methods (TensorDet, PFT, and iFOD2) and converted into voxelwise individualized priors. Functionnectome maps were estimated using both standardized and individualized priors, and Z-statistic activation maps were obtained via GLM analysis. Similarity metrics and atlas-based consistency were used to compare standardized and individualized Functionnectomes.

Functionnectomes derived from probabilistic tractography showed moderate correlations with standardized Functionnectomes (average Pearson’s r ≈ 0.5), highlighting the influence of individual structural variability while maintaining comparable activation patterns. The PFT-based Functionnectome exhibited superior anatomical plausibility, with consistent overlap with expected motor white matter tracts and identification of relevant bundles in up to 100% of cases, compared to 50–60% with standardized priors.

The individualized Functionnectome enhances the anatomical validity and subject specificity of structure–function mapping, advancing precision neuroimaging for clinical and neurosurgical applications.

功能组框架使任务相关的fMRI信号投射到潜在的白质通路上，使用来自结构连接的解剖学先验。然而，现有的“标准化”先验是基于健康对照的平均神经束图，不能准确捕获脑病变患者的解剖结构变化。本研究通过从受试者特异性弥散MRI神经束造影中生成个性化解剖先验，扩展了功能组框架，从而改善了脑肿瘤患者功能和结构数据的整合。26例胶质瘤患者（9名女性，平均年龄43±17岁）接受了3t MRI，包括多壳扩散方案和针对运动和/或语言功能的任务型功能磁共振成像。使用三种方法（TensorDet、PFT和iFOD2）重建全脑束图，并将其转换为体素个体化先验。使用标准化和个性化先验估计功能组图，并通过GLM分析获得z统计激活图。相似性指标和基于图谱的一致性用于比较标准化和个性化功能组。从概率神经束造影中得到的功能组与标准化功能组显示出适度的相关性（平均Pearson’s r≈0.5），突出了个体结构变异性的影响，同时保持了可比较的激活模式。基于pft的功能组显示出优越的解剖学合理性，与预期的运动白质束和相关束的识别在高达100%的病例中一致重叠，而标准化的先前为50-60%。个性化的功能组增强了结构-功能映射的解剖学有效性和主题特异性，促进了临床和神经外科应用的精确神经成像。

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引用次数: 0

White matter structure-function decoupling in juvenile myoclonic epilepsy 青少年肌阵挛性癫痫的白质结构-功能解耦

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2026.103945

Junrui Zhang , Guangyao Liu , Yongxuan Xu , Chi Zhang , Hong Liu , Laiyan Ma , Weihao Zheng , Baoming Li , Zhe Zhang

Objective

Accumulating evidence highlights both structural and functional brain alterations in juvenile myoclonic epilepsy (JME), yet how these structural changes within white matter pathways drive functional disorganization remains largely unknown. Here, we aim to investigate white matter structure–function coupling (SFC) in treatment-naïve, newly diagnosed JME.

Methods

Forty-seven patients with JME and 40 demographically matched healthy controls underwent diffusion-weighted imaging (DWI) and resting-state functional magnetic resonance imaging (fMRI). Tract-wise SFC was assessed using a multivariate linear regression, with the amplitude of low-frequency fluctuations as the dependent variable and four microstructural metrics—fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)—as independent variables. A support vector regression with five-fold cross-validation was employed to establish the associations with clinical severity.

Results

JME patients exhibited widespread white matter microstructural alterations, including increased FA and decreased diffusivity metrics, alongside functional hyperactivity in multiple tracts. Notably, a significant reduction of SFC was observed in the left corticospinal tract (P = 0.008) and left inferior longitudinal fasciculus (P = 0.006). In addition, multimodal models combining structural, functional, and coupling metrics demonstrated superior predictive performance for clinical severity compared to single-modal analyses (P = 0.026).

Conclusion

These findings highlight white matter structure–function decoupling in the early stages of JME, specifically in key pathways relevant to motor and cognitive dysfunctions. Furthermore, the tract-specific SFC investigation offers a useful way for diagnosis, prognosis, and guiding personalized treatment strategies in this complex epilepsy syndrome.

目的越来越多的证据强调了青少年肌挛性癫痫（JME）的结构和功能改变，但这些白质通路中的结构变化如何驱动功能紊乱仍然很大程度上未知。在此，我们旨在研究treatment-naïve新诊断的JME中的白质结构-功能耦合（SFC）。方法对47例JME患者和40例人口统计学匹配的健康对照者进行弥散加权成像（DWI）和静息状态功能磁共振成像（fMRI）检查。以低频波动幅度为因变量，以四种微观结构指标——分数各向异性（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）——为自变量，采用多元线性回归对通道方向SFC进行评估。采用五重交叉验证的支持向量回归来确定与临床严重程度的关联。结果jme患者表现出广泛的白质微结构改变，包括FA增加和弥漫性指标降低，以及多束功能亢进。值得注意的是，左侧皮质脊髓束（P = 0.008）和左侧下纵束（P = 0.006）的SFC明显减少。此外，与单模态分析相比，结合结构、功能和耦合指标的多模态模型对临床严重程度的预测效果更好（P = 0.026）。结论这些发现强调了JME早期白质结构-功能脱钩，特别是在与运动和认知功能障碍相关的关键通路上。此外，在这种复杂的癫痫综合征中，通道特异性SFC研究为诊断、预后和指导个性化治疗策略提供了有用的方法。

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引用次数: 0

Neural substrates of the oculomotor vergence network for concussion-related convergence insufficiency within the CONCUSS study CONCUSS研究中与脑震荡相关的会聚不足的动眼肌会聚网络的神经基质

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2026.103955

Ayushi Sangoi , Farzin Hajebrahimi , Suril Gohel , Mitchell Scheiman , Arlene Goodman , Melissa Noble , Tara L. Alvarez

Concussion-related convergence insufficiency (CONC-CI) participants were compared to binocularly normal controls (BNC) using an fMRI stimulus-induced vergence oculomotor task to assess group-level differences in neural substrates. The hypothesis tested was whether the CONC-CI and BNC groups would show significant differences in the vergence oculomotor neural substrates, providing comparative data for the CONCUSS randomized clinical trial or future therapeutic longitudinal studies. A pediatrician diagnosed concussions, and an optometrist diagnosed convergence insufficiency. The CONC-CI group experienced their last concussion between one and six months since the last injury and had persisting post-concussion symptoms. A total of 46 BNC and 59 CONC-CI participants underwent a sensory-motor vision exam and had datasets from the fMRI experiment that passed a priori criteria for motion artifacts. The BNC group exhibited activation within the parietal eye field (PEF), supplemental eye field (SEF), frontal eye field (FEF), visual cortex, and cerebellum. Activation in these regions was present but significantly reduced in the PEF, cerebellum, and visual cortex for the CONC-CI group compared to BNC (FWE p < 0.05). The CONC-CI group had greater activation in the precuneus than the BNC group (FWE p < 0.05). Significant differences in the correlation between the near point of convergence and the convergence insufficiency symptom survey (CISS) with the functional activity of the PEF and the PFt region of the inferior parietal cortex were observed across groups (BNC versus CONC-CI) (p < 0.001). Together, these findings demonstrate how functional activity is affected by CONC-CI, particularly in individuals with persisting post-concussion symptoms. Future therapeutic intervention studies are discussed.

通过fMRI刺激诱导的会聚动眼肌任务，将脑震荡相关会聚不全（concc - ci）参与者与双眼正常对照（BNC）进行比较，以评估神经基质在组水平上的差异。检验的假设是concs - ci组和BNC组在会聚动神经底物上是否会表现出显著差异，为CONCUSS随机临床试验或未来的治疗性纵向研究提供比较数据。儿科医生诊断为脑震荡，验光师诊断为会聚功能不全。concc - ci组在最后一次受伤后的一到六个月内经历了最后一次脑震荡，并且持续出现脑震荡后症状。共有46名BNC和59名cc - ci参与者接受了感觉-运动视觉检查，并获得了通过运动伪影先验标准的fMRI实验数据集。BNC组在顶叶视野（PEF）、辅助视野（SEF）、额叶视野（FEF）、视觉皮层和小脑内表现出激活。与BNC相比，CONC-CI组的PEF、小脑和视觉皮层的这些区域存在激活，但明显减少（FWE p < 0.05）。cc - ci组楔前叶的活化程度高于BNC组（FWE p < 0.05）。近收敛点和收敛功能不全症状调查（CISS）与下顶叶皮质PEF和PFt区域功能活动的相关性在各组间观察到显著差异（BNC与concc - ci）（p < 0.001）。总之，这些发现证明了功能活动如何受到concc - ci的影响，特别是在持续脑震荡后症状的个体中。讨论了未来的治疗干预研究。

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引用次数: 0

Spatiotemporal brain dynamics in 8-to-9-year-old children: A comparative study between preterm and term schoolchildren 8 ~ 9岁儿童的时空脑动力学：早产儿和足学龄儿童的比较研究。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2026.103949

Solange Denervaud , Paola Zanchi , Céline J Fischer Fumeaux , Cléo Huguenin-Virchaux , Laureline Besuchet , Patric Hagmann , Anita C Truttmann , Juliane Schneider

Preterm birth disrupts critical phases of brain maturation, placing individuals at increased risk for long-term cognitive and functional impairments. This study investigated how very preterm birth affects the spatial and temporal organization of functional brain networks in school-aged children born very preterm using a spatiotemporal connectome framework. Multimodal MRI, including diffusion-weighted imaging and resting-state fMRI, was acquired from 25 children born before 30 gestational weeks and 25 age- and sex-matched full-term controls (8–9 years). We characterized the structure–function coupling of dynamic brain activity through Connected Components (CCs) defined as structurally constrained sets of functionally co-active regions identified on a multilayer graph. Three different metrics were computed: CC number (count of distinct co-activation patterns), CC height (peak number of regions within a CC, representing the spatial extent) and CC width (temporal span across consecutive time repetitions (TRs)). In addition, we quantified System Diversity (SD) and Spatiotemporal Diversity (STD), indices reflecting integrative richness and temporal variability of functional network dynamics. CC number decreased with age across groups, reflecting typical developmental patterns, while CC height was significantly greater in preterm children and positively associated with processing speed, suggesting altered or compensatory network co-activation. No significant group differences were observed for SD metrics. However, network-level analyses revealed significantly lower STD values in all functional networks in the preterm group, indicating possible heightened temporal stability and reduced functional flexibility. These findings suggest that very preterm birth selectively alters the dynamic engagement of functional systems, with potential implications for cognitive vulnerabilities. (243 mots; 250 max).

早产扰乱了大脑成熟的关键阶段，使个体面临长期认知和功能障碍的风险增加。本研究利用时空连接体框架研究了极早产如何影响极早产学龄儿童功能性脑网络的时空组织。多模态MRI，包括弥散加权成像和静息状态功能磁共振成像，从25名出生在30孕周之前的儿童和25名年龄和性别匹配的足月对照组（8-9岁）中获得。我们通过连接组件（cc）描述了动态大脑活动的结构-功能耦合，连接组件定义为多层图上识别的功能协同活动区域的结构约束集。计算了三个不同的指标：CC数（不同共激活模式的计数）、CC高度（代表空间范围的CC内区域的峰数）和CC宽度（连续时间重复（TRs）的时间跨度）。此外，我们还量化了系统多样性（SD）和时空多样性（STD）这两个反映功能网络动态的综合丰富度和时间变异性的指标。CC数随年龄的增长而减少，反映了典型的发育模式，而CC高度在早产儿中显著增加，并与加工速度呈正相关，表明网络共激活发生了改变或代偿。SD指标组间无显著差异。然而，网络水平分析显示，早产组所有功能网络的STD值显著降低，表明可能时间稳定性增强，功能灵活性降低。这些发现表明，非常早产选择性地改变了功能系统的动态参与，对认知脆弱性有潜在的影响。（243小时；最多250小时）。

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引用次数: 0

White matter alterations linked to social cognitive improvements following theta burst stimulation of the right inferior frontal gyrus in autism 自闭症患者右额下回θ波爆发刺激后白质改变与社会认知改善有关

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2026.103948

Chun-Hung Yeh , Jing-Ru Chen , Yi-Ping Chao , Chen-Te Wu , Tai-Li Chou , Susan Shur-Fen Gau , Hsing-Chang Ni , Hsiang-Yuan Lin

Objectives

Intermittent theta burst stimulation (iTBS) over the right inferior frontal gyrus (RIFG) has been shown to improve social cognitive function in autistic individuals. However, whether this intervention modulates underlying brain structure remains unknown. This study aimed to investigate the impact of iTBS over the RIFG on white matter macro- and micro-structure in intellectually able autistic children and young adults.

Materials and methods

In this 8-week double-blind, parallel, sham-controlled trial, autistic participants (aged 8–30 years) were randomized to receive twice-weekly neuro-navigated iTBS targeting the RIFG or sham stimulation using a sham coil applied over the same target. The social cognitive performance was measured with the Frith-Happé Animations Test. Diffusion MRI and behavioral assessments were acquired at baseline, week 8 (immediately after intervention), and week 12 (four-week follow-up). After quality control, data from 26 participants in the active group and 23 in the sham group were included in the final longitudinal whole-brain fixel-based analysis (FBA).

Results

No significant treatment-by-time interaction emerged: changes in the composite fiber-density-and-cross-section (FDC) metric did not differ between groups at either week 8 or week 12. Within the active group, however, a significant negative association was found between the change in FDC in the rostral body of the corpus callosum and the improvement in social cognitive performance from baseline to week 12.

Conclusions

An 8-week course of neuro-navigated RIFG iTBS did not produce significant group-level white matter macro/microstructural changes compared to sham stimulation in our autistic cohort. Nevertheless, the finding that individual improvements in social cognition correlated with specific white matter alterations in the active group suggests a potential link between treatment-induced benefits and neural plasticity. Future studies should investigate whether different TBS parameters could induce more pronounced or detectable structural changes on MRI in autistic individuals and further explore the intricate mechanisms underlying observed brain-behavior relationships.

目的研究右额下回间歇θ波爆发刺激（iTBS）对自闭症患者社会认知功能的改善作用。然而，这种干预是否会调节潜在的大脑结构仍然未知。本研究旨在探讨iTBS加RIFG对智力自闭症儿童和青年脑白质宏观和微观结构的影响。材料和方法在这项为期8周的双盲、平行、假对照试验中，自闭症参与者（8-30岁）被随机分为两组，一组接受针对RIFG的神经导航iTBS，另一组接受针对同一目标的假线圈的假刺激。社会认知表现用弗里思-快乐动画测试来衡量。在基线、第8周（干预后立即）和第12周（四周随访）进行弥散性MRI和行为评估。经过质量控制，26名活跃组和23名假手术组的数据被纳入最终的纵向全脑固定分析（FBA）。结果：在第8周和第12周，复合纤维密度和横截面（FDC）指标的变化在两组之间没有差异。然而，在活跃组中，从基线到第12周，胼胝体吻侧体FDC的变化与社会认知表现的改善之间存在显著的负相关。结论与假刺激相比，8周的神经导航RIFG iTBS治疗没有产生显著的组水平白质宏观/微观结构变化。然而，这一发现表明，在积极组中，个体社会认知的改善与特定的白质改变相关，这表明治疗引起的益处与神经可塑性之间存在潜在的联系。未来的研究应该探讨不同的TBS参数是否会在自闭症患者的MRI上引起更明显或可检测的结构变化，并进一步探索观察到的脑行为关系背后的复杂机制。

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引用次数: 0

Structural brain alterations and predictors of clinical improvement in functional cognitive disorder after concussion 脑震荡后功能性认知障碍的脑结构改变和临床改善的预测因素。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103936

Christiana Westlin , Mathilde Rioux , Jaqueline Lee , William Panenka , Daniela J. Palombo , Rebecca M. Todd , Noah D. Silverberg , David L. Perez

Functional cognitive disorder (FCD) is an under-studied yet likely prevalent subtype of functional neurological disorder (FND), with neural mechanisms that remain poorly understood. While studies of other FND subtypes have revealed structural and functional brain alterations across several large-scale brain networks, no study to date has investigated neural alterations in FCD. Here, we examined structural grey matter brain differences as measured from magnetic resonance imaging in 37 adults with FCD after concussion compared to 25 post-concussion controls. We compared FreeSurfer-based cortical thickness and subcortical volumes between groups and investigated associations between structural measures and memory symptoms. A subset of participants with FCD (n = 24) participated in a randomized controlled trial of cognitive-behavioral therapy vs. cognitive rehabilitation, and relationships between baseline structural measures and treatment outcomes were evaluated. All primary analyses were adjusted for age, sex, estimated IQ, and loss of consciousness, and corrected for multiple comparisons. No significant between-group differences in cortical thickness or subcortical volume were observed. However, across all participants, greater functional memory symptom severity was associated with larger right amygdala volume, which remained significant adjusting for depression scores, anxiety scores, and psychotropic medication use. Post-hoc analyses identified that this observation was driven by differences in lateral, basal, and paralaminar amygdalar nuclei. Additionally, greater improvement in memory symptoms following treatment was associated with increased pre-treatment cortical thickness in the right inferior frontal gyrus. These findings provide initial insights into the structural neurobiology of FCD and its associations with symptom severity and clinical trajectories.

功能性认知障碍（FCD）是功能性神经障碍（FND）的一种尚未得到充分研究但可能普遍存在的亚型，其神经机制仍然知之甚少。虽然其他FND亚型的研究已经揭示了几个大规模脑网络的结构和功能改变，但迄今为止还没有研究调查FCD的神经改变。在这里，我们通过磁共振成像检测了37名成年FCD脑震荡患者与25名脑震荡后对照组脑灰质结构的差异。我们比较了两组之间基于freesurfer的皮质厚度和皮质下体积，并调查了结构测量与记忆症状之间的关联。一组FCD患者（n = 24）参加了一项认知行为治疗与认知康复的随机对照试验，并评估了基线结构测量与治疗结果之间的关系。所有的初步分析都根据年龄、性别、估计智商和意识丧失进行了调整，并对多重比较进行了修正。各组间皮质厚度和皮质下体积无显著差异。然而，在所有参与者中，更大的功能记忆症状严重程度与更大的右杏仁核体积相关，这在抑郁评分、焦虑评分和精神药物使用方面仍然是显著的。事后分析表明，这一观察结果是由外侧核、基底核和线旁核的差异引起的。此外，治疗后记忆症状的更大改善与治疗前右侧额下回皮质厚度的增加有关。这些发现为FCD的结构神经生物学及其与症状严重程度和临床轨迹的关联提供了初步见解。

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引用次数: 0

Fetal functional connectivity prospectively associates with autistic traits in toddlerhood 胎儿功能连接可能与幼儿期自闭症特征相关。

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103938

Bosi Chen , Iris Menu , Lanxin Ji , Christopher J. Trentacosta , Moriah E. Thomason

Accumulating evidence from neuroimaging studies has implicated widespread disruptions in brain connectivity in autism spectrum disorder (ASD), with altered connectivity patterns reported as early as infancy. However, it remains unexplored whether functional connectivity differences are evident prior to birth in the brain of fetuses who will later exhibit autistic traits in early childhood. In this study, we leveraged a longitudinal sample of 62 children with both quality-assured fetal brain resting-state MRI data and a parent-report measure of autistic traits at age 3 years. Enrichment analysis was employed to identify network pairs significantly correlated with autistic traits. Specificity analysis was conducted by additionally controlling for other childhood psychopathology. Our results demonstrated significant correlations between autistic traits and functional connectivity in the cingulate-left temporal and right prefrontal-left operculum network pairs in both the primary and specificity analyses. Visual network connectivity with prefrontal and opercular regions was also implicated. These network pairs demonstrated positive associations with autistic traits, indicating that stronger connectivity between these network pairs was associated with higher autistic traits. In contrast, weaker cerebellum-right operculum connectivity was associated with higher autistic traits, uniquely in the specificity analysis. This study provides the first in vivo evidence prospectively linking variation in functional network connectivity in the fetal brain to autistic traits in toddlerhood. These findings extend the current understanding of the prenatal brain origins of ASD and highlight the potential of fetal rs-fMRI as a tool to identify neural signatures related to social-emotional development and ASD likelihood.

来自神经影像学研究的越来越多的证据表明，自闭症谱系障碍（ASD）的大脑连接普遍中断，早在婴儿时期就有报道称连接模式发生改变。然而，功能连接差异是否在胎儿出生前就明显存在，这些胎儿后来会在儿童早期表现出自闭症特征，这一问题仍未得到探讨。在这项研究中，我们利用了62名儿童的纵向样本，包括有质量保证的胎儿大脑静息状态MRI数据和3岁时父母报告的自闭症特征测量。富集分析发现与自闭症性状显著相关的网络对。另外控制其他儿童精神病理进行特异性分析。我们的研究结果在初级和特异性分析中都证明了自闭症特征与扣带-左颞叶和右前额叶-左脑盖网络对的功能连通性之间存在显著相关性。前额叶和眼区的视觉网络连通性也有牵连。这些网络对与自闭症特征呈正相关，表明这些网络对之间更强的连通性与更高的自闭症特征相关。相反，较弱的小脑-右脑盖连通性与较高的自闭症特征相关，这在特异性分析中是独一无二的。这项研究首次提供了胎儿大脑功能网络连接变化与幼儿期自闭症特征之间的活体证据。这些发现扩展了目前对ASD的产前大脑起源的理解，并强调了胎儿rs-fMRI作为识别与社会情感发展和ASD可能性相关的神经特征的工具的潜力。

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引用次数: 0

Resting state functional connectivity patterns associate with alcohol use disorder characteristics: Insights from the triple network model 静息状态功能连接模式与酒精使用障碍特征相关：来自三重网络模型的见解

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2025.103939

Daniel Guerrero , Mario Dzemidzic , Mahdi Moghaddam , Mintao Liu , Andrea Avena-Koenigsberger , Jaroslaw Harezlak , David A. Kareken , Martin H. Plawecki , Melissa A. Cyders , Joaquín Goñi

Prolonged alcohol use results in neuroadaptations that mark more severe and treatment-resistant alcohol use. The goal of this study was to identify functional connectivity brain patterns underlying Alcohol Use Disorder (AUD)-related characteristics in fifty-five adults (31 female) who endorsed heavy alcohol use. We hypothesized that resting-state functional connectivity (rsFC) of the Salience (SN), Frontoparietal (FPN), and Default Mode (DMN) networks would reflect self-reported recent and lifetime alcohol use, laboratory-based alcohol seeking, urgency, and sociodemographic characteristics related to AUD. To test our hypothesis, we combined the triple network model (TNM) of psychopathology with a multivariate data-driven approach, regularized partial least squares (rPLS), to unfold concurrent functional connectivity (FC) patterns and their association with AUD-related characteristics. We observed three concurrent associations of interest: i) drinking and age-related cross communication between the SN and both the FPN and DMN; ii) family history density of AUD and urgency anticorrelations between the SN and FPN; and iii) alcohol seeking and sex-associated SN and DMN interactions. These findings provide an integrative interpretation for many individual findings reported in the literature relating functional connectivity signatures and AUD factors. Moreover, we identified a set of neural mechanisms and brain regions concomitant with AUD-related characteristics that can serve as potential treatment targets across clinical and preclinical models.

长期饮酒导致神经适应，这标志着更严重和更难以治疗的酒精使用。本研究的目的是在55名重度饮酒的成年人（31名女性）中确定酒精使用障碍（AUD）相关特征的功能连接脑模式。我们假设，显著性（SN）、额顶叶（FPN）和默认模式（DMN）网络的静息状态功能连接（rsFC）将反映自我报告的近期和终生酒精使用情况、实验室酒精寻求、紧迫性和与AUD相关的社会人口学特征。为了验证我们的假设，我们将精神病理学的三重网络模型（TNM）与多变量数据驱动方法（正则化偏最小二乘（rPLS））结合起来，揭示并发功能连接（FC）模式及其与aud相关特征的关联。我们观察到三个并发的兴趣关联：1)饮酒和SN与FPN和DMN之间与年龄相关的交叉交流；ii) AUD家族史密度与SN与FPN的紧急反相关关系；iii)嗜酒和与性相关的SN和DMN相互作用。这些发现为文献中有关功能连接特征和AUD因素的许多个体发现提供了综合解释。此外，我们确定了一组与aud相关特征相关的神经机制和大脑区域，这些特征可以作为临床和临床前模型的潜在治疗靶点。

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引用次数: 0

Structural correlates of aphasia severity, cognitive impairment, and outcome after stroke 脑卒中后失语严重程度、认知障碍和预后的结构相关性

IF 3.6 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical

Pub Date : 2026-01-01 DOI: 10.1016/j.nicl.2026.103954

Célise Haldin , Hélène Lœvenbruck , Céline Piscicelli , Valérie Marcon , Shenhao Dai , Olivier Detante , Dominic Pérennou , Monica Baciu

In this study, we aimed to identify structural biomarkers linked to the severity and outcome of aphasia after a left-hemispheric stroke. We recruited 72 individuals with post-stroke aphasia and assessed their initial aphasia severity using the Aphasia Severity Rating Scale, alongside measures of naming ability and executive function. Aphasia outcome was determined for 56 out of 72 participants with available Aphasia Severity Rating Scale scores at discharge. We performed support-vector regression symptom mapping analyses at both cortical and white matter levels to examine the relationship between structural brain damage and our variables of interest (initial aphasia severity, naming, executive functions, and aphasia outcome). Our results revealed that (a) disconnections in white matter tracts within ventral and dorsal language pathways were associated with aphasia severity and naming deficits initially; and (b) disconnections in white matter tracts within executive networks (i.e., fronto-parietal, executive control, and salience networks) were related to executive dysfunction. This retrospective cohort study highlighted the crucial roles of white matter tracts within both dorsal (i.e., arcuate fasciculus, superior longitudinal fasciculus) and ventral (uncinate, inferior longitudinal, and middle longitudinal fasciculi) language streams in shaping the cognitive phenotypes of post-stroke aphasia patients, particularly concerning aphasia severity and naming impairment, by delineating distinct patterns of affected brain structures.

在这项研究中，我们旨在确定与左半球中风后失语的严重程度和结果相关的结构生物标志物。我们招募了72名中风后失语症患者，并使用失语症严重程度评定量表评估他们最初的失语症严重程度，同时测量他们的命名能力和执行功能。在72名参与者中，有56名在出院时使用失语症严重程度评定量表评分确定失语症结局。我们在皮质和白质水平上进行了支持向量回归症状映射分析，以检查结构性脑损伤与我们感兴趣的变量（初始失语严重程度、命名、执行功能和失语结果）之间的关系。我们的研究结果显示：(a)最初，腹侧和背侧语言通路内白质束的断开与失语症的严重程度和命名缺陷有关；(b)执行网络（即额顶叶、执行控制和突出网络）内白质束的断开与执行功能障碍有关。这项回顾性队列研究强调了白质束在背侧（即弓形束、上纵束）和腹侧（钩状束、下纵束和中纵束）语言流中的关键作用，通过描绘受影响的大脑结构的不同模式，在塑造中风后失语症患者的认知表型中，特别是在失语症严重程度和命名障碍方面。

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引用次数: 0