Risk assessment of RNAi-based biopesticides

New Crops Pub Date : 2024-03-18 DOI:10.1016/j.ncrops.2024.100019

Xuming Luo , Satyabrata Nanda , Youjun Zhang , Xuguo Zhou , Chunxiao Yang , Huipeng Pan

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Abstract

RNA interference (RNAi) is an efficient molecular approach in which double-stranded RNA (dsRNA) can effectively knock down the expression of certain genes, promoting mRNA degradation, and gene function loss. Based on the principle of RNAi, a novel and eco-friendly biopesticide has been characterized and used in recent years. RNAi-based biopesticides have high specificity, efficiency, and easy degradation, which have ushered in the third revolution in the history of pesticides. Additionally, these properties of RNAi-based biopesticides are of great significance in achieving sustainable agricultural development. However, before the market release of any biopesticides, it is essential to consider whether they will adversely affect human health and the environment. This paper reviews RNAi-based biopesticides' different modes of action and the diverse associated risks, such as environmental risk (environmental fate, off-target effects, exposure assessment, and resistance development), human health risk, and government policies.

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基于 RNAi 的生物农药的风险评估

RNA 干扰（RNAi）是一种高效的分子方法，双链 RNA（dsRNA）能有效地敲除某些基因的表达，促进 mRNA 降解和基因功能丧失。基于 RNAi 的原理，近年来一种新型、环保的生物农药得到了表征和应用。基于 RNAi 的生物农药具有特异性强、高效、易降解等特点，开创了农药史上的第三次革命。此外，RNAi 生物农药的这些特性对于实现农业可持续发展具有重要意义。然而，在任何生物农药投放市场之前，必须考虑其是否会对人类健康和环境造成不利影响。本文综述了基于 RNAi 的生物农药的不同作用模式及其相关的各种风险，如环境风险（环境归宿、非靶标效应、暴露评估和抗药性发展）、人类健康风险和政府政策。

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New Crops

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