Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial.

IF 0.8 Q3 ANESTHESIOLOGY JA Clinical Reports Pub Date : 2024-03-26 DOI:10.1186/s40981-024-00703-6

Masahiro Kazawa, Daijiro Kabata, Hisako Yoshida, Kimito Minami, Takuma Maeda, Kenji Yoshitani, Hitoshi Matsuda, Ayumi Shintani

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Abstract

Background: This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).

Methods: This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.

Results: Sixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention group versus 18 patients (56.2%) in the control group (adjusted hazard ratio, 0.44; 95% confidence interval, 0.20-0.95; P = 0.04).

Conclusions: This trial demonstrated a significant reduction in AKI incidence with amino acid supplementation.

Trial registration: jRCT, jRCTs051210154. Registered 31 December 2021, https://jrct.niph.go.jp/re/reports/detail/69916.

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预防心脏手术相关急性肾损伤的氨基酸：随机对照试验。

背景：本研究旨在探讨氨基酸对术后急性肾损伤（AKI）的预防作用：本研究旨在探讨氨基酸对术后急性肾损伤（AKI）的预防作用：这是一项单中心、患者和评估者双盲的随机对照试验。研究对象包括接受主动脉手术并进行心肺旁路的患者。干预组每天服用 60 克氨基酸，最长 3 天。对照组接受标准护理。主要结果是 AKI 的发生率。我们使用 Cox 比例危险回归模型评估了氨基酸对 AKI 的影响：66名患者被随机分配到对照组或干预组。对照组中有一名患者在随机分配后撤回同意书。干预组 AKI 发生率为 10 例（30.3%），对照组为 18 例（56.2%）（调整后危险比为 0.44；95% 置信区间为 0.20-0.95；P = 0.04）：该试验表明，补充氨基酸可显著降低AKI发生率。试验注册：jRCT，jRCTs051210154。注册日期：2021 年 12 月 31 日，https://jrct.niph.go.jp/re/reports/detail/69916。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JA Clinical Reports ANESTHESIOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： JA Clinical Reports is a companion journal to the Journal of Anesthesia (JA), the official journal of the Japanese Society of Anesthesiologists (JSA). This journal is an open access, peer-reviewed, online journal related to clinical anesthesia practices such as anesthesia management, pain management and intensive care. Case reports are very important articles from the viewpoint of education and the cultivation of scientific thinking in the field of anesthesia. However, submissions of anesthesia research and clinical reports from Japan are notably decreasing in major anesthesia journals. Therefore, the JSA has decided to launch a new journal, JA Clinical Reports, to encourage JSA members, particularly junior Japanese anesthesiologists, to publish papers in English language.