Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial.

Pub Date : 2024-03-26 DOI:10.1186/s40981-024-00703-6

Masahiro Kazawa, Daijiro Kabata, Hisako Yoshida, Kimito Minami, Takuma Maeda, Kenji Yoshitani, Hitoshi Matsuda, Ayumi Shintani

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Abstract

Background: This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).

Methods: This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.

Results: Sixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention group versus 18 patients (56.2%) in the control group (adjusted hazard ratio, 0.44; 95% confidence interval, 0.20-0.95; P = 0.04).

Conclusions: This trial demonstrated a significant reduction in AKI incidence with amino acid supplementation.

Trial registration: jRCT, jRCTs051210154. Registered 31 December 2021, https://jrct.niph.go.jp/re/reports/detail/69916.

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预防心脏手术相关急性肾损伤的氨基酸：随机对照试验。

背景：本研究旨在探讨氨基酸对术后急性肾损伤（AKI）的预防作用：本研究旨在探讨氨基酸对术后急性肾损伤（AKI）的预防作用：这是一项单中心、患者和评估者双盲的随机对照试验。研究对象包括接受主动脉手术并进行心肺旁路的患者。干预组每天服用 60 克氨基酸，最长 3 天。对照组接受标准护理。主要结果是 AKI 的发生率。我们使用 Cox 比例危险回归模型评估了氨基酸对 AKI 的影响：66名患者被随机分配到对照组或干预组。对照组中有一名患者在随机分配后撤回同意书。干预组 AKI 发生率为 10 例（30.3%），对照组为 18 例（56.2%）（调整后危险比为 0.44；95% 置信区间为 0.20-0.95；P = 0.04）：该试验表明，补充氨基酸可显著降低AKI发生率。试验注册：jRCT，jRCTs051210154。注册日期：2021 年 12 月 31 日，https://jrct.niph.go.jp/re/reports/detail/69916。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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