Choriocapillaris flow features in children with myopic anisometropia.

IF 3.7 2区医学 Q1 OPHTHALMOLOGY British Journal of Ophthalmology Pub Date : 2024-10-22 DOI:10.1136/bjo-2022-323020

Zhihao Jiang, Wu Bo, Zhengfei Yang, Xiaoling Luo, Yao Ni, Junwen Zeng

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Abstract

Aims: To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia.

Methods: In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by optical coherence tomography angiography (OCTA). The OCTA image was divided into a 1 mm-diameter central circle (C1) and a 2.5 mm-diameter annulus (without the inner central 1 mm circle, C1-2.5). Both C1 and C1-2.5 are centred on the foveola. The C1-2.5 was divided into nasal (N1-2.5), temporal (T1-2.5), inferior (I1-2.5) and superior (S1-2.5) areas. Differences in these parameters in different regions between eyes were analysed.

Results: There were no significant differences in the percentage of flow voids and the average flow void area between the fellow eyes. The total number of signal voids was significantly higher in the less myopic eyes in C1-2.5 (p=0.032), S1-2.5 (p=0.008) and N1-2.5 (p=0.019). Changes in spherical equivalent refraction and axial length were both correlated with the changes in the total number of flow voids in N1-2.5 (R=-0.431, p=0.03; R=-0.297, p=0.047).

Conclusions: The choroid in the macular region becomes thinner and the total number of flow voids in the nasal macular region decreased with the amplitude of myopia. This suggests that a decrease in total number of flow voids may indicate an early change in myopia.

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近视性斜视儿童的绒毛膜血流特征

目的：研究近视性斜视儿童双眼绒毛膜灌注和脉络膜厚度的差异：在这项观察性和前瞻性研究中，共招募了 46 名近视性斜视儿童。通过光学相干断层血管成像（OCTA）获得绒毛膜灌注参数，包括流空百分比、流空总数和平均流空面积。OCTA 图像分为直径为 1 毫米的中心圆（C1）和直径为 2.5 毫米的环面（不包括中心 1 毫米的内圆，C1-2.5）。C1 和 C1-2.5 都以眼窝为中心。C1-2.5 被分为鼻区（N1-2.5）、颞区（T1-2.5）、下区（I1-2.5）和上区（S1-2.5）。分析了这些参数在不同区域的差异：结果：两眼间的血流空洞百分比和平均血流空洞面积没有明显差异。近视度数较低的眼睛在 C1-2.5（p=0.032）、S1-2.5（p=0.008）和 N1-2.5 （p=0.019）的信号空洞总数明显较多。在 N1-2.5 中，球面等效屈光度和轴长的变化均与流空总数的变化相关（R=-0.431，p=0.03；R=-0.297，p=0.047）：结论：随着近视度数的增加，黄斑区的脉络膜变薄，鼻腔黄斑区的流动空洞总数减少。结论：黄斑区的脉络膜变薄，鼻腔黄斑区的流动空洞总数随近视幅度的增加而减少，这表明流动空洞总数的减少可能预示着近视的早期变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.40%

发文量

213

审稿时长

3-6 weeks

期刊介绍： The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.