Outdoor Artificial Light at Night and Reproductive Endocrine and Glucose Homeostasis and Polycystic Ovary Syndrome in Women of Reproductive Age.

IF 4.7 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Epidemiology Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI:10.1097/EDE.0000000000001736

Lanlan Fang, Cong Ma, Guosheng Wang, Yongzhen Peng, Hui Zhao, Yuting Chen, Yubo Ma, Guoqi Cai, Yunxia Cao, Faming Pan

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Abstract

Background: Artificial light at night, a well-recognized circadian clock disrupter, causes disturbances in endocrine homeostasis. However, the association of artificial light at night with polycystic ovary syndrome (PCOS) is still unknown. This study examines the effects of outdoor artificial light at night on sex hormones, glucose homeostasis markers, and PCOS prevalence in Anhui Province, China.

Methods: We recruited 20,633 women of reproductive age from Anhui Medical University Reproductive Medicine Center. PCOS was diagnosed according to Rotterdam criteria. We estimated long-term (previous year) and short-term (previous month) artificial light at night values for residential addresses using 500 m resolution satellite imagery. We fitted multivariable models, using both linear and logistic regression, to estimate the association of artificial light at night with sex hormones, glucose homeostasis markers, and PCOS prevalence.

Results: Both long-term and short-term exposure to outdoor artificial light at night were negatively associated with follicle-stimulating hormone and luteinizing hormone levels, while positively associated with testosterone, fasting insulin, homeostasis model assessment-insulin resistance, and homeostasis model assessment-insulin resistance-β levels. The second-highest quintile of artificial light at night was associated with increased PCOS prevalence (odds ratio [OR long-term ] = 1.4; 95% confidence interval [CI] = 1.2, 1.6 and OR short-term = 1.3; 95% CI = 1.1, 1.5) compared with the lowest quintile. In addition, prevalence of PCOS was linearly associated with long-term exposure to artificial light at night, but nonlinearly associated with short-term exposure. This association was more evident in younger, obese or overweight, moderately educated, rural women, and for the summer and fall seasons.

Conclusion: Outdoor artificial light at night may be a novel risk factor for PCOS.

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夜间室外人造光与育龄妇女的生殖内分泌和葡萄糖稳态以及多囊卵巢综合征。

背景：夜间人造光是公认的昼夜节律干扰因素，会导致内分泌平衡紊乱。然而，夜间人造光与多囊卵巢综合征（PCOS）之间的关系尚不清楚。本研究探讨了中国安徽省夜间室外人工光对性激素、糖稳态指标和多囊卵巢综合征发病率的影响：方法：我们从安徽医科大学生殖医学中心招募了 20633 名育龄妇女。根据鹿特丹标准诊断多囊卵巢综合征。我们利用分辨率为 500 米的卫星图像估算了住宅地址的长期（前一年）和短期（前一个月）夜间人工光照值。我们利用线性回归和逻辑回归建立了多变量模型，以估算夜间人造光与性激素、葡萄糖稳态指标和多囊卵巢综合征发病率之间的关系：结果：长期和短期暴露于夜间户外人造光与卵泡刺激素（FSH）和黄体生成素（LH）水平呈负相关，而与睾酮、空腹胰岛素、HOMA-IR 和 HOMA-β 水平呈正相关。与最低五分位数相比，夜间人工光照的第二高五分位数与多囊卵巢综合症患病率增加有关（长期 OR =1.4，95% CI：1.2,1.6）；短期 OR =1.3，95% CI：1.1,1.5）。此外，多囊卵巢综合症的发病率与长期暴露于夜间人造光呈线性关系，但与短期暴露呈非线性关系。这种关联在年轻、肥胖或超重、受过中等教育、农村妇女以及夏秋季节更为明显：结论：夜间户外人造光可能是导致多囊卵巢综合症的一个新的风险因素。

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来源期刊

Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.70%

发文量

177

审稿时长

6-12 weeks

期刊介绍： Epidemiology publishes original research from all fields of epidemiology. The journal also welcomes review articles and meta-analyses, novel hypotheses, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.