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Association of Early-life Trauma With Gestational Diabetes and Hypertensive Disorders of Pregnancy. 早期生活创伤与妊娠期糖尿病和妊娠期高血压疾病的关系。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2024-12-31 DOI: 10.1097/EDE.0000000000001817
Sharonda M Lovett, Jennifer M P Woo, Katie M O'Brien, Samantha E Parker, Dale P Sandler

Background: Early-life trauma (before age of 18 years) is hypothesized to increase the risk for adverse pregnancy outcomes through stress pathways, yet epidemiologic findings are mixed.

Methods: Sister Study participants (US women aged 35-74 years enrolled 2003-2009) completed an adapted Brief Betrayal Trauma Survey at the first follow-up visit. Lifetime history of gestational diabetes mellitus (GDM) or hypertensive disorders of pregnancy (HDP: pregnancy-related high blood pressure, pre-eclampsia/toxemia, or eclampsia) in pregnancies lasting ≥20 weeks was self-reported. We used log-binomial regression to estimate relative risks (RR) and 95% confidence intervals (CIs) for the association between early-life trauma (modeled using conventional measures [e.g., any experience, substantive domains, individual types] and latent classes of co-occurring traumas) and GDM or HDP among 34,879 parous women.

Results: Approximately, 4% of participants reported GDM and 11% reported HDP. Relative to no early-life trauma, the RRs for any were 1.1 (95% CI = 1.0, 1.3) for GDM and 1.2 (95% CI = 1.2, 1.3) for HDP. Women reporting physical trauma had the highest risk of GDM and HDP in comparison to other substantive domains. In analyses using latent classes of early-life trauma, high trauma was associated with an elevated risk of both GDM (RR = 1.9, 95% CI = 1.5, 2.6) and HDP (RR = 1.7, 95% CI = 1.4, 2.0) compared with low trauma.

Conclusions: Women experiencing high levels of trauma in early life were at higher risk of GDM and HDP, adding to a growing evidence base for this association.

背景:早期生活创伤(18岁之前)被假设通过应激途径增加不良妊娠结局的风险,但流行病学研究结果喜忧参半。方法:姐妹研究参与者(2003-2009年入组的35-74岁美国女性)在第一次随访时完成了一份改编的简短背叛创伤调查。自我报告妊娠≥20周的妊娠期糖尿病(GDM)或妊娠期高血压疾病(HDP:妊娠相关性高血压、先兆子痫/毒血症或子痫)的终生病史。我们使用对数二项回归来估计34,879名产妇中早期生活创伤(使用常规测量方法[例如,任何经历、实质性领域、个体类型]和共同发生创伤的潜在类别建模)与GDM或HDP之间的关联的相对风险(RR)和95%置信区间(CI)。结果:大约4%的参与者报告GDM, 11%报告HDP。相对于没有早期生活创伤,GDM的rr为1.1 (95% CI = 1.0, 1.3), HDP的rr为1.2 (95% CI = 1.2, 1.3)。与其他实质性领域相比,报告身体创伤的妇女患GDM和HDP的风险最高。在使用潜在类别的早期创伤的分析中,与低创伤相比,高创伤与GDM (RR = 1.9, 95% CI = 1.5, 2.6)和HDP (RR = 1.7, 95% CI = 1.4, 2.0)的风险升高相关。结论:早期经历高水平创伤的女性患GDM和HDP的风险更高,这为这种关联增加了越来越多的证据基础。
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引用次数: 0
Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017. 亚特兰大大都会地区的流感活动与早产:2010年至2017年的时间序列分析。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1097/EDE.0000000000001819
Xiaping Zheng, Tingyu Wang, Hua Hao, Rohan R D'Souza, Matthew J Strickland, Joshua L Warren, Lyndsey A Darrow, Howard H Chang

Background: Annual influenza epidemics lead to a substantial public health burden, and pregnant people are vulnerable to severe outcomes. Influenza during pregnancy is hypothesized to increase the risk of adverse birth outcomes, but population-based epidemiologic evidence remains limited and inconsistent.

Methods: We conducted a time-series analysis to estimate short-term associations between community-level seasonal influenza activity and daily counts of preterm births in Atlanta, United States from October 17, 2010 to July 10, 2017. We defined weekly influenza exposures four ways: (1) percent test-positive from virologic surveillance, (2) percent of patients with symptoms of influenza-like illness (ILI) in outpatient settings, (3) a composite measure of percent test-positive and ILI, and (4) influenza hospitalization rates. We used Poisson log-linear models to estimate associations, adjusting for time-varying confounders and ongoing at-risk pregnancies. We further examined associations by influenza type and exposure lags and effect modification by maternal characteristics.

Results: We studied a total of 316,253 births. We found consistent positive associations between influenza activity and preterm birth across different exposure measures and exposure lags. An interquartile range increase in a composite measure of ILI activity and percent test-positive was associated with a 1.014 (95% confidence interval: 1.001-1.027) increase in preterm birth during the same week. In stratified analyses, associations were more pronounced among married, non-Black, and Hispanic pregnant people.

Conclusion: Periods of high influenza activity were associated with an increased risk of preterm birth.

背景:每年的流感疫情都会给公共卫生带来巨大负担,而孕妇很容易出现严重后果。据推测,孕期流感会增加不良分娩结局的风险,但基于人群的流行病学证据仍然有限且不一致:我们进行了一项时间序列分析,以估计 2010 年 10 月 17 日至 2017 年 7 月 10 日期间美国亚特兰大社区级季节性流感活动与早产儿日计数之间的短期关联。我们用四种方法定义了每周的流感暴露情况:(1)病毒学监测中检测呈阳性的百分比;(2)门诊中出现流感样病症状(ILI)的患者百分比;(3)检测呈阳性百分比和 ILI 的综合指标;(4)流感住院率。我们使用泊松对数线性模型来估计相关性,并对时变混杂因素和正在进行的高危妊娠进行了调整。我们还进一步研究了流感类型和暴露滞后的相关性,以及孕产妇特征对影响的修饰作用:我们总共研究了 316,253 例新生儿。我们发现,在不同的暴露量和暴露滞后期,流感活动与早产之间存在一致的正相关关系。流感嗜血杆菌活动度和检测阳性率的综合指标在四分位数范围内的增加与同一周内早产率增加 1.014(95% 置信区间:1.001, 1.027)有关。在分层分析中,已婚、非黑人和西班牙裔孕妇的相关性更为明显:结论:流感高发期与早产风险增加有关。
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引用次数: 0
Erratum: Natural effects with a recanting witness: non-identifiability or meaningless estimand?
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1097/EDE.0000000000001806
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引用次数: 0
Socioeconomic Status, Smoking, and Lung Cancer: Mediation and Bias Analysis in the SYNERGY Study. 社会经济地位、吸烟和肺癌:SYNERGY 研究中的中介和偏差分析。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2023-10-22 DOI: 10.1097/EDE.0000000000001807
Jan Hovanec, Benjamin Kendzia, Ann Olsson, Joachim Schüz, Hans Kromhout, Roel Vermeulen, Susan Peters, Per Gustavsson, Enrica Migliore, Loredana Radoi, Christine Barul, Dario Consonni, Neil E Caporaso, Maria Teresa Landi, John K Field, Stefan Karrasch, Heinz-Erich Wichmann, Jack Siemiatycki, Marie-Elise Parent, Lorenzo Richiardi, Lorenzo Simonato, Karl-Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Guillermo Fernández-Tardón, David Zaridze, John R McLaughlin, Paul A Demers, Beata Świątkowska, Jolanta Lissowska, Tamás Pándics, Eleonora Fabianova, Dana Mates, Miriam Schejbalova, Lenka Foretova, Vladimír Janout, Paolo Boffetta, Francesco Forastiere, Kurt Straif, Thomas Brüning, Thomas Behrens

Background: Increased lung cancer risks for low socioeconomic status (SES) groups are only partially attributable to smoking habits. Little effort has been made to investigate the persistent risks related to low SES by quantification of potential biases.

Methods: Based on 12 case-control studies, including 18 centers of the international SYNERGY project (16,550 cases, 20,147 controls), we estimated controlled direct effects (CDE) of SES on lung cancer via multiple logistic regression, adjusted for age, study center, and smoking habits and stratified by sex. We conducted mediation analysis by inverse odds ratio weighting to estimate natural direct effects and natural indirect effects via smoking habits. We considered misclassification of smoking status, selection bias, and unmeasured mediator-outcome confounding by genetic risk, both separately and by multiple quantitative bias analyses, using bootstrap to create 95% simulation intervals (SI).

Results: Mediation analysis of lung cancer risks for SES estimated mean proportions of 43% in men and 33% in women attributable to smoking. Bias analyses decreased the direct effects of SES on lung cancer, with selection bias showing the strongest reduction in lung cancer risk in the multiple bias analysis. Lung cancer risks remained increased for lower SES groups, with higher risks in men (fourth vs. first [highest] SES quartile: CDE, 1.50 [SI, 1.32, 1.69]) than women (CDE: 1.20 [SI: 1.01, 1.45]). Natural direct effects were similar to CDE, particularly in men.

Conclusions: Bias adjustment lowered direct lung cancer risk estimates of lower SES groups. However, risks for low SES remained elevated, likely attributable to occupational hazards or other environmental exposures.

背景:低社会经济地位(SES)群体肺癌风险的增加仅部分归因于吸烟习惯。通过量化潜在的偏差来研究与低社会经济地位相关的持续风险的工作很少:基于 12 项病例对照研究,包括国际 SYNERGY 项目的 18 个中心(16,550 例病例,20,147 例对照),我们通过多元逻辑回归估算了 SES 对肺癌的直接控制效应(CDE),并对年龄、研究中心和吸烟习惯进行了调整,同时按性别进行了分层。我们通过反比例加权法进行了中介分析,以估计自然直接效应(NDE)和通过吸烟习惯产生的自然间接效应。我们考虑了吸烟状况的误分类、选择偏倚和遗传风险造成的未测量中介结果混淆,既单独考虑了这些因素,也进行了多重定量偏倚分析,并使用引导法创建了95%模拟区间(SI):对肺癌风险进行的社会经济地位中介分析估计,吸烟对男性和女性的平均影响比例分别为43%和33%。偏倚分析降低了社会经济地位对肺癌的直接影响,在多重偏倚分析中,选择偏倚对肺癌风险的降低作用最强。较低社会经济地位组的肺癌风险仍然增加,男性[第四与第一(最高)社会经济地位四分位数:CDE 1.50 (SI 1.32-1.69)]的肺癌风险高于女性[CDE 1.20 (SI 1.01-1.45)]。NDE与CDE相似,尤其是男性:结论:偏差调整降低了较低社会经济地位群体的直接肺癌风险估计值。然而,低社会经济地位人群的风险仍然较高,这可能是由于职业危害或其他环境暴露造成的。
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引用次数: 0
Back to Basics: What Descriptive Epidemiology Can Teach Us About the Recent Rise in Firearm Homicide. 回到基础:描述流行病学可以告诉我们最近枪支杀人事件的上升。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1097/EDE.0000000000001827
Veronica A Pear, Julia P Schleimer
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引用次数: 0
The Association Between Ambient Particulate Matter Exposure and Anemia in HIV/AIDS Patients. 环境颗粒物暴露与艾滋病毒/艾滋病患者贫血之间的关系
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2024-12-31 DOI: 10.1097/EDE.0000000000001825
Wei Liang, Aojing Han, Dong Hou, Ruihan Li, Qilin Hu, Huanfeng Shen, Yalei Jin, Hao Xiang

Background: Anemia is common among HIV/AIDS patients, impacting prognosis. Particulate matter (PM) exposure is an understudied, potentially modifiable risk factor in this group.

Methods: We gathered 36,266 hemoglobin (Hb) measurements from 6808 HIV/AIDS patients from the HIV/AIDS Comprehensive Response Information Management System from 1 January 2004 to 31 December 2021. We evaluated the relationship between Hb levels and short-term PM exposure using linear mixed-effects models. We used logistic regression to estimate the association of long-term PM exposure with baseline anemia prevalence and time-varying Cox models to estimate the association of long-term PM exposure with follow-up incidence of anemia. Mediation analysis explored the role of chronic kidney disease (CKD) in the association between PM exposure and anemia.

Results: For every 5 µg/m³ increase in 28-day average PM 1 , Hb levels decreased by 0.43 g/l. For a 10 µg/m³ increase in PM 2.5 , Hb decreased by 0.55 g/l; for the same increase in PM 10, Hb decreased by 0.35 g/l. A 5 µg/m³ increase in 1-year average PM 1 corresponded to a 7% higher prevalence of anemia at baseline, a 10 µg/m³ increase in PM 2.5 to 8% higher prevalence, and a 10 µg/m³ increase in PM 10 to 6% higher prevalence. These rises in average PM concentrations during follow-up were associated with increased incident anemia by 54% (PM 1 ), 72% (PM 2.5 ), and 51% (PM 10 ). CKD partially mediated the positive associations between PM exposure and the incidence of anemia.

Conclusion: PM exposure was associated with lower Hb levels and higher incidence of anemia in HIV/AIDS patients and CKD with mediating estimated effects in PM-induced anemia.

背景:贫血在HIV/AIDS患者中很常见,影响预后。在这一群体中,颗粒物(PM)暴露是一个未被充分研究的、潜在可改变的风险因素。方法:从2004年1月1日至2021年12月31日,从HIV/AIDS综合应对信息管理系统中收集6808名HIV/AIDS患者的36266个血红蛋白(Hb)检测结果。我们使用线性混合效应模型评估Hb水平与短期PM暴露之间的关系。我们使用逻辑回归来估计长期PM暴露与基线贫血患病率的关系,并使用时变Cox模型来估计长期PM暴露与随访贫血发生率的关系。中介分析探讨慢性肾脏疾病(CKD)在PM暴露和贫血之间的关联中的作用。结果:28天平均PM1每增加5µg/m³,Hb水平降低0.43 g/L。PM2.5每增加10µg/m³,Hb下降0.55 g/L;PM10升高相同,Hb降低0.35 g/L。1年平均PM1增加5µg/m³对应于基线时贫血患病率增加7%,PM2.5增加10µg/m³对应于患病率增加8%,PM10增加10µg/m³对应于患病率增加6%。随访期间平均PM浓度的升高与贫血发生率增加54% (PM1)、72% (PM2.5)和51% (PM10)相关。慢性肾病部分介导了PM暴露与贫血发生率之间的正相关关系。结论:PM暴露与HIV/AIDS患者较低的Hb水平和较高的贫血发生率有关,CKD在PM诱导的贫血中具有中介作用。
{"title":"The Association Between Ambient Particulate Matter Exposure and Anemia in HIV/AIDS Patients.","authors":"Wei Liang, Aojing Han, Dong Hou, Ruihan Li, Qilin Hu, Huanfeng Shen, Yalei Jin, Hao Xiang","doi":"10.1097/EDE.0000000000001825","DOIUrl":"10.1097/EDE.0000000000001825","url":null,"abstract":"<p><strong>Background: </strong>Anemia is common among HIV/AIDS patients, impacting prognosis. Particulate matter (PM) exposure is an understudied, potentially modifiable risk factor in this group.</p><p><strong>Methods: </strong>We gathered 36,266 hemoglobin (Hb) measurements from 6808 HIV/AIDS patients from the HIV/AIDS Comprehensive Response Information Management System from 1 January 2004 to 31 December 2021. We evaluated the relationship between Hb levels and short-term PM exposure using linear mixed-effects models. We used logistic regression to estimate the association of long-term PM exposure with baseline anemia prevalence and time-varying Cox models to estimate the association of long-term PM exposure with follow-up incidence of anemia. Mediation analysis explored the role of chronic kidney disease (CKD) in the association between PM exposure and anemia.</p><p><strong>Results: </strong>For every 5 µg/m³ increase in 28-day average PM 1 , Hb levels decreased by 0.43 g/l. For a 10 µg/m³ increase in PM 2.5 , Hb decreased by 0.55 g/l; for the same increase in PM 10, Hb decreased by 0.35 g/l. A 5 µg/m³ increase in 1-year average PM 1 corresponded to a 7% higher prevalence of anemia at baseline, a 10 µg/m³ increase in PM 2.5 to 8% higher prevalence, and a 10 µg/m³ increase in PM 10 to 6% higher prevalence. These rises in average PM concentrations during follow-up were associated with increased incident anemia by 54% (PM 1 ), 72% (PM 2.5 ), and 51% (PM 10 ). CKD partially mediated the positive associations between PM exposure and the incidence of anemia.</p><p><strong>Conclusion: </strong>PM exposure was associated with lower Hb levels and higher incidence of anemia in HIV/AIDS patients and CKD with mediating estimated effects in PM-induced anemia.</p>","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"216-226"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-level PM 2.5 Exposure, Cardiovascular and Nonaccidental Mortality, and Related Health Disparities in 12 US States. 美国 12 个州的低浓度 PM2.5 暴露、心血管和非事故死亡率以及相关的健康差异。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2023-11-22 DOI: 10.1097/EDE.0000000000001820
Adjani A Peralta, Edgar Castro, Mahdieh Danesh Yazdi, Anna Kosheleva, Yaguang Wei, Joel Schwartz

Background: Investigations into long-term fine particulate matter (PM 2.5 ) exposure's impact on nonaccidental and cardiovascular (CVD) deaths primarily involve nonrepresentative adult populations at concentrations above the new Environmental Protection Agency annual PM 2.5 standard.

Methods: Using generalized linear models, we studied PM 2.5 exposure on rates of five mortality outcomes (all nonaccidental, CVD, myocardial infarction, stroke, and congestive heart failure) in 12 US states from 2000 to 2016. We aggregated predicted annual PM 2.5 exposures from a validated ensemble exposure model, ambient temperature from Daymet predictions, and mortality rates to all census tract-years within the states. We obtained covariates from the decennial Census and the American Community Surveys and assessed effect measure modification by race and education with stratification.

Results: For each 1-µg/m 3 increase in annual PM 2.5 , we found positive associations with all five mortality outcomes: all nonaccidental (1.08%; 95% confidence interval [CI]: 0.96%, 1.20%), all CVD (1.27%; 95% CI: 1.14%, 1.41%), myocardial infarction (1.89%; 95% CI: 1.67%, 2.11%), stroke (1.08%; 95% CI: 0.87%, 1.30%), and congestive heart failure (2.20%; 95% CI: 1.97%, 2.44%). Positive associations persisted at <8 µg/m 3 PM 2.5 levels and among populations with only under 65. In our study, race, but not education, modifies associations. High-educated Black had a 2.90% larger increased risk of CVD mortality (95% CI: 2.42%, 3.39%) compared with low-educated non-Black.

Conclusion: Long-term PM 2.5 exposure is associated with nonaccidental and CVD mortality in 12 states, below the new Environmental Protection Agency standard, for both low PM 2.5 regions and the general population. Vulnerability to CVD mortality persists among Black individuals regardless of education level.

背景:有关长期暴露于细颗粒物(PM2.5)对非意外死亡和心血管疾病(CVD)死亡影响的调查主要涉及浓度高于美国环保署(EPA)PM2.5年度新标准的非代表性成年人群:使用广义线性模型,我们研究了 2000-2016 年间美国 12 个州的 PM2.5 暴露对五种死亡率结果(所有非事故、心血管疾病、心肌梗死 (MI)、中风和充血性心力衰竭 (CHF))的影响。我们汇总了经过验证的集合暴露模型预测的 PM2.5 年暴露量、Daymet 预测的环境温度以及各州内所有人口普查区年的死亡率。我们从十年一次的人口普查和美国社区调查中获得了协变量,并通过分层评估了种族和教育程度对效应测量的修正:结果:PM2.5年浓度每增加1-ug/m3,我们发现与所有五种死亡结果都有正相关:所有非事故死亡(1.08%;95% CI:0.96%, 1.20%)、所有心血管疾病(1.27%;95% CI:1.14%,1.41%)、心肌梗死(1.89%;95% CI:1.67%,2.11%)、中风(1.08%;95% CI:0.87%,1.30%)和慢性心力衰竭(2.20%;95% CI:1.97%,2.44%)。这种正相关关系在结论中依然存在:在美国 12 个州,PM2.5 的长期暴露与非事故死亡率和心血管疾病死亡率相关,低于美国环保局的新标准。无论受教育程度如何,黑人都容易死于心血管疾病。
{"title":"Low-level PM 2.5 Exposure, Cardiovascular and Nonaccidental Mortality, and Related Health Disparities in 12 US States.","authors":"Adjani A Peralta, Edgar Castro, Mahdieh Danesh Yazdi, Anna Kosheleva, Yaguang Wei, Joel Schwartz","doi":"10.1097/EDE.0000000000001820","DOIUrl":"10.1097/EDE.0000000000001820","url":null,"abstract":"<p><strong>Background: </strong>Investigations into long-term fine particulate matter (PM 2.5 ) exposure's impact on nonaccidental and cardiovascular (CVD) deaths primarily involve nonrepresentative adult populations at concentrations above the new Environmental Protection Agency annual PM 2.5 standard.</p><p><strong>Methods: </strong>Using generalized linear models, we studied PM 2.5 exposure on rates of five mortality outcomes (all nonaccidental, CVD, myocardial infarction, stroke, and congestive heart failure) in 12 US states from 2000 to 2016. We aggregated predicted annual PM 2.5 exposures from a validated ensemble exposure model, ambient temperature from Daymet predictions, and mortality rates to all census tract-years within the states. We obtained covariates from the decennial Census and the American Community Surveys and assessed effect measure modification by race and education with stratification.</p><p><strong>Results: </strong>For each 1-µg/m 3 increase in annual PM 2.5 , we found positive associations with all five mortality outcomes: all nonaccidental (1.08%; 95% confidence interval [CI]: 0.96%, 1.20%), all CVD (1.27%; 95% CI: 1.14%, 1.41%), myocardial infarction (1.89%; 95% CI: 1.67%, 2.11%), stroke (1.08%; 95% CI: 0.87%, 1.30%), and congestive heart failure (2.20%; 95% CI: 1.97%, 2.44%). Positive associations persisted at <8 µg/m 3 PM 2.5 levels and among populations with only under 65. In our study, race, but not education, modifies associations. High-educated Black had a 2.90% larger increased risk of CVD mortality (95% CI: 2.42%, 3.39%) compared with low-educated non-Black.</p><p><strong>Conclusion: </strong>Long-term PM 2.5 exposure is associated with nonaccidental and CVD mortality in 12 states, below the new Environmental Protection Agency standard, for both low PM 2.5 regions and the general population. Vulnerability to CVD mortality persists among Black individuals regardless of education level.</p>","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"253-263"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Authors Respond. 回复致编辑的信,“回复:阴性试验设计与明确目标试验模拟队列设计评估COVID-19疫苗有效性的比较”。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI: 10.1097/EDE.0000000000001813
Guilin Li, Miguel A Hernán, Barbra A Dickerman
{"title":"The Authors Respond.","authors":"Guilin Li, Miguel A Hernán, Barbra A Dickerman","doi":"10.1097/EDE.0000000000001813","DOIUrl":"10.1097/EDE.0000000000001813","url":null,"abstract":"","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"e1-e2"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness. Re:检测阴性设计与明确目标试验模拟的队列设计用于评估COVID-19疫苗有效性的比较
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI: 10.1097/EDE.0000000000001812
Neil Pearce, Thiago Cerqueira-Silva, Jan P Vandenbroucke
{"title":"Re: Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness.","authors":"Neil Pearce, Thiago Cerqueira-Silva, Jan P Vandenbroucke","doi":"10.1097/EDE.0000000000001812","DOIUrl":"10.1097/EDE.0000000000001812","url":null,"abstract":"","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"e1"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Authors Respond. 作者回应。
IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1097/EDE.0000000000001814
Edgar Ortiz-Brizuela, Mireille E Schnitzer, Mabel Carabali, Denis Talbot
{"title":"The Authors Respond.","authors":"Edgar Ortiz-Brizuela, Mireille E Schnitzer, Mabel Carabali, Denis Talbot","doi":"10.1097/EDE.0000000000001814","DOIUrl":"10.1097/EDE.0000000000001814","url":null,"abstract":"","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"e2-e3"},"PeriodicalIF":4.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Epidemiology
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