Mangiferin, a Potential Supplement to Improve Metabolic Syndrome: Current Status and Future Opportunities.

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-03-26 DOI:10.1142/S0192415X24500150
Gelin Xiang, Sa Guo, Nan Xing, Qinyun Du, Jing Qin, Huimin Gao, Yi Zhang, Shaohui Wang
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Abstract

Metabolic syndrome (MetS) represents a considerable clinical and public health burden worldwide. Mangiferin (MF), a flavonoid compound present in diverse species such as mango (Mangifera indica L.), papaya (Pseudocydonia sinensis (Thouin) C. K. Schneid.), zhimu (Anemarrhena asphodeloides Bunge), and honeybush tea (Cyclopia genistoides), boasts a broad array of pharmacological effects. It holds promising uses in nutritionally and functionally targeted foods, particularly concerning MetS treatment. It is therefore pivotal to systematically investigate MF's therapeutic mechanism for MetS and its applications in food and pharmaceutical sectors. This review, with the aid of a network pharmacology approach complemented by this experimental studies, unravels possible mechanisms underlying MF's MetS treatment. Network pharmacology results suggest that MF treats MetS effectively through promoting insulin secretion, targeting obesity and inflammation, alleviating insulin resistance (IR), and mainly operating via the phosphatidylinositol 3 kinase (PI3K)/Akt, nuclear factor kappa-B (NF-[Formula: see text]B), microtubule-associated protein kinase (MAPK), and oxidative stress signaling pathways while repairing damaged insulin signaling. These insights provide a comprehensive framework to understand MF's potential mechanisms in treating MetS. These, however, warrant further experimental validation. Moreover, molecular docking techniques confirmed the plausibility of the predicted outcomes. Hereafter, these findings might form the theoretical bedrock for prospective research into MF's therapeutic potential in MetS therapy.

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芒果苷,一种改善代谢综合征的潜在补充剂:现状与未来机遇。
代谢综合征(MetS)给全球临床和公共卫生带来了相当大的负担。芒果苷(Mangiferin,MF)是一种黄酮类化合物,存在于芒果(Mangifera indica L.)、木瓜(Pseudocydonia sinensis (Thouin) C. K. Schneid.)、茨木(Anemarrhena asphodeloides Bunge)和蜜丛茶(Cyclopia genistoides)等不同物种中,具有广泛的药理作用。它在营养和功能靶向食品方面具有广阔的用途,尤其是在治疗代谢综合征方面。因此,系统研究 MF 对 MetS 的治疗机制及其在食品和制药领域的应用至关重要。本综述借助网络药理学方法并辅以实验研究,揭示了 MF 治疗 MetS 的可能机制。网络药理学结果表明,MF 通过促进胰岛素分泌、靶向肥胖和炎症、缓解胰岛素抵抗(IR),以及主要通过磷脂酰肌醇 3 激酶(PI3K)/Akt、核因子卡巴-B(NF-[式:见正文]B)、微管相关蛋白激酶(MAPK)和氧化应激信号通路有效治疗 MetS,同时修复受损的胰岛素信号传导。这些见解为了解 MF 治疗 MetS 的潜在机制提供了一个全面的框架。不过,这些还需要进一步的实验验证。此外,分子对接技术也证实了预测结果的合理性。此后,这些发现可能会成为未来研究 MF 在 MetS 治疗中的治疗潜力的理论基础。
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