Photo-Sono activated fluorine-doped titanium-based bone implants for rapid osteosarcoma eradication and bacterial infection elimination

Abstract

Inadequate elimination of tumor cells, bacterial infection, and insufficient bone fusion are the primary factors contributing to the recurrence of osteosarcoma and implant failure. To overcome these challenges, a multifunctional bioactive titanium-based implant consisting of fluorine-doped titanium dioxide (TiO₂) nanoparticles was designed for synergistic therapy activated by near-infrared II (NIR-II) light and ultrasound. The F-doped TiO₂ nanoparticles exhibit excellent photothermal and acoustic properties upon excitation by 1060 nm NIR-II laser and ultrasound, respectively. The synergistic effect of hyperthermia and reactive oxygen species (ROS) under photoacoustic action endows the TiO₂ nanoparticles with remarkable anti-tumor and anti-bacterial activities, enabling them to eradicate Saos-2 cells within 10 min and S. aureus within 15 min. Meanwhile, the nanostructured surface and appropriate doping of F endow nanoparticles with excellent bone promoting ability.