{"title":"Antiarrhythmic drugs","authors":"Georgina Sutcliffe, Benjamin Jones, Cally Burnard","doi":"10.1016/j.mpaic.2024.02.001","DOIUrl":null,"url":null,"abstract":"<div><p>Around 3.7 million people worldwide die each year from cardiac arrhythmias. Despite advances in catheter ablation therapies and implantable devices, there have been few advances in pharmacological therapy. Advances in the understanding of channel subtypes has led to the proposed modification of the Vaughan Williams classification system. However, each drug has a unique pharmacokinetic profile meaning that often the class of a drug bears little clinical relevance. Many drugs also have sites of action outside of their class which may account for the generation of proarrhythmias. The advances in understanding of specific ion channel subtypes may provide the opportunity for target-specific drugs with improved safety profiles.</p></div>","PeriodicalId":45856,"journal":{"name":"Anaesthesia and Intensive Care Medicine","volume":"25 4","pages":"Pages 281-285"},"PeriodicalIF":0.2000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaesthesia and Intensive Care Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1472029924000262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Around 3.7 million people worldwide die each year from cardiac arrhythmias. Despite advances in catheter ablation therapies and implantable devices, there have been few advances in pharmacological therapy. Advances in the understanding of channel subtypes has led to the proposed modification of the Vaughan Williams classification system. However, each drug has a unique pharmacokinetic profile meaning that often the class of a drug bears little clinical relevance. Many drugs also have sites of action outside of their class which may account for the generation of proarrhythmias. The advances in understanding of specific ion channel subtypes may provide the opportunity for target-specific drugs with improved safety profiles.
期刊介绍：
Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.
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