Magnesium-reinforced Electrospun Synthetic-polymer Nanofibers Designed for Promoting Tissue Growth

IF 4.9 3区计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Journal of Bionic Engineering Pub Date : 2024-03-26 DOI:10.1007/s42235-024-00495-6

Muheeb Rafiq, Anjum Hamid Rather, Rumysa Saleem Khan, Taha Umair Wani, Haseeb A. Khan, Abdullah S. Alhomida, Faheem A. Sheikh

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Abstract

The creation of 3D nanofibers offering desirable functions for bone regeneration is developed due to the latest improvisations to the electrospinning technique. Synthetic polymers are among the best choices for medical usage due to their lower costs, high tensile properties, and ease of spinnability compared to natural polymers. In this communication, we report a series of interventions to polymers modified with Mg-based fillers for ideal tissue engineering applications. The literature survey indicated that these filler materials (e.g., nano-sized particles) enhanced biocompatibility, antibacterial activity, tensile strength, and anti-corrosive properties. This review discusses electrospinning parameters, properties, and applications of the poly(ε-caprolactone), poly(lactic acid), poly(3-hydroxybutyric acid-co-3-hydroxy valeric acid), polyurethane, and poly(vinyl pyrrolidone) nanofibers when modified with Mg-based fillers. This report encourages researchers to use synthetic polymers with Mg as fillers and validate them for tissue engineering applications.

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用于促进组织生长的镁增强电纺合成聚合物纳米纤维

摘要由于电纺丝技术的最新改进，三维纳米纤维的制造得到了发展，为骨再生提供了理想的功能。与天然聚合物相比，合成聚合物成本低、拉伸性能高且易于纺丝，是医疗用途的最佳选择之一。在这篇通讯中，我们报告了一系列针对理想组织工程应用的镁基填料改性聚合物的干预措施。文献调查显示，这些填充材料（如纳米级颗粒）增强了生物相容性、抗菌活性、拉伸强度和抗腐蚀性。本综述讨论了聚(ε-己内酯)、聚(乳酸)、聚(3-羟基丁酸-co-3-羟基戊酸)、聚氨酯和聚乙烯吡咯烷酮纳米纤维用镁基填料改性后的电纺丝参数、性能和应用。本报告鼓励研究人员使用含镁的合成聚合物作为填充物，并对其在组织工程方面的应用进行验证。

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来源期刊

Journal of Bionic Engineering 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

10.00%

发文量

162

审稿时长

10.0 months

期刊介绍： The Journal of Bionic Engineering (JBE) is a peer-reviewed journal that publishes original research papers and reviews that apply the knowledge learned from nature and biological systems to solve concrete engineering problems. The topics that JBE covers include but are not limited to: Mechanisms, kinematical mechanics and control of animal locomotion, development of mobile robots with walking (running and crawling), swimming or flying abilities inspired by animal locomotion. Structures, morphologies, composition and physical properties of natural and biomaterials; fabrication of new materials mimicking the properties and functions of natural and biomaterials. Biomedical materials, artificial organs and tissue engineering for medical applications; rehabilitation equipment and devices. Development of bioinspired computation methods and artificial intelligence for engineering applications.