Pub Date : 2026-01-13DOI: 10.1007/s42235-025-00827-0
Kourosh Kakhi, Hamzeh Asgharnezhad, Abbas Khosravi, Roohallah Alizadehsani, U. Rajendra Acharya
Accurate detection of driver fatigue is essential for improving road safety. This study investigates the effectiveness of using multimodal physiological signals for fatigue detection while incorporating uncertainty quantification to enhance the reliability of predictions. Physiological signals, including Electrocardiogram (ECG), Galvanic Skin Response (GSR), and Electroencephalogram (EEG), were transformed into image representations and analyzed using pretrained deep neural networks. The extracted features were classified through a feedforward neural network, and prediction reliability was assessed using uncertainty quantification techniques such as Monte Carlo Dropout (MCD), model ensembles, and combined approaches. Evaluation metrics included standard measures (sensitivity, specificity, precision, and accuracy) along with uncertainty-aware metrics such as uncertainty sensitivity and uncertainty precision. Across all evaluations, ECG-based models consistently demonstrated strong performance. The findings indicate that combining multimodal physiological signals, Transfer Learning (TL), and uncertainty quantification can significantly improve both the accuracy and trustworthiness of fatigue detection systems. This approach supports the development of more reliable driver assistance technologies aimed at preventing fatigue-related accidents.
{"title":"Fatigue Detection with Multimodal Physiological Signals via Uncertainty-Aware Deep Transfer Learning","authors":"Kourosh Kakhi, Hamzeh Asgharnezhad, Abbas Khosravi, Roohallah Alizadehsani, U. Rajendra Acharya","doi":"10.1007/s42235-025-00827-0","DOIUrl":"10.1007/s42235-025-00827-0","url":null,"abstract":"<div><p>Accurate detection of driver fatigue is essential for improving road safety. This study investigates the effectiveness of using multimodal physiological signals for fatigue detection while incorporating uncertainty quantification to enhance the reliability of predictions. Physiological signals, including Electrocardiogram (ECG), Galvanic Skin Response (GSR), and Electroencephalogram (EEG), were transformed into image representations and analyzed using pretrained deep neural networks. The extracted features were classified through a feedforward neural network, and prediction reliability was assessed using uncertainty quantification techniques such as Monte Carlo Dropout (MCD), model ensembles, and combined approaches. Evaluation metrics included standard measures (sensitivity, specificity, precision, and accuracy) along with uncertainty-aware metrics such as uncertainty sensitivity and uncertainty precision. Across all evaluations, ECG-based models consistently demonstrated strong performance. The findings indicate that combining multimodal physiological signals, Transfer Learning (TL), and uncertainty quantification can significantly improve both the accuracy and trustworthiness of fatigue detection systems. This approach supports the development of more reliable driver assistance technologies aimed at preventing fatigue-related accidents.</p></div>","PeriodicalId":614,"journal":{"name":"Journal of Bionic Engineering","volume":"23 1","pages":"472 - 487"},"PeriodicalIF":5.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1007/s42235-025-00821-6
Han Yang, Ya Fang, Jiaming Cui, Xueheng Sun, Tianchang Wang, Liang Feng, Hao Yang, Changru Zhang, Bide Xu, Xiaojun Zhou, Jinwu Wang, Xudong Wang
Treating bone defects complicated by bacterial infections remains a significant clinical challenge. Drawing inspiration from the human body’s bone repair mechanisms, the use of biomimetic methods to design tissue engineering scaffolds is of great significance for bone repair. This study synthesized copper (Cu)-doped mesoporous silica nanoparticles (Cu@MSN) modified with hydroxyethyl methacrylate to obtain methacrylated Cu@MSN (Cu@MSNMA). Furtheremore, biomimetic nanocomposite hydrogels were prepared by adding Cu@MSNMA to a GelMA/gelatin solution. This hydrogel achieves multi-modal bone tissue biomimicry: (i) GelMA/gelatin mimics the matrix components in bone ECM, ensuring biocompatibility while promoting cellular behavior (such as adhesion, proliferation, and differentiation); (ii) GelMA/gelatin and the crosslinking sites introduced by Cu@MSNMA form a stable porous network structure, achieving structural and mechanical biomimicry to provide necessary support for bone defects; (iii) The elemental biomimicry of Si and Cu in Cu@MSNMA achieves efficient osteogenic induction. The effect of different proportions of Cu@MSNMA on the physical properties of the composite hydrogels was investigated to determine the optimal proportion. The results indicated that the mechanical properties of hydrogel were enhanced with the increasing Cu@MSNMA mass ratio. Notably, 5% NPs/GelMA/gelatin hydrogel exhibited excellent mechanical property compared to the GelMA/gelatin hydrogel. In vitro and vivo cellular experiments demonstrated a significant enhancement in antibacterial and osteogenic induction with Cu@MSNMA addition. In conclusion, the proposed nanocomposite hydrogel with biomimetic components and ion-regulating properties can serve as a multifunctional scaffold, offering antimicrobial properties for infected bone regeneration, and guide for future research in bone regeneration and three-dimensional printing.
{"title":"Bionic Design of Copper-doped Mesoporous Silica with Enhanced Hydrogel Mechanical Properties and its Promising Application in Bone-defect Regeneration","authors":"Han Yang, Ya Fang, Jiaming Cui, Xueheng Sun, Tianchang Wang, Liang Feng, Hao Yang, Changru Zhang, Bide Xu, Xiaojun Zhou, Jinwu Wang, Xudong Wang","doi":"10.1007/s42235-025-00821-6","DOIUrl":"10.1007/s42235-025-00821-6","url":null,"abstract":"<div><p>Treating bone defects complicated by bacterial infections remains a significant clinical challenge. Drawing inspiration from the human body’s bone repair mechanisms, the use of biomimetic methods to design tissue engineering scaffolds is of great significance for bone repair. This study synthesized copper (Cu)-doped mesoporous silica nanoparticles (Cu@MSN) modified with hydroxyethyl methacrylate to obtain methacrylated Cu@MSN (Cu@MSNMA). Furtheremore, biomimetic nanocomposite hydrogels were prepared by adding Cu@MSNMA to a GelMA/gelatin solution. This hydrogel achieves multi-modal bone tissue biomimicry: (i) GelMA/gelatin mimics the matrix components in bone ECM, ensuring biocompatibility while promoting cellular behavior (such as adhesion, proliferation, and differentiation); (ii) GelMA/gelatin and the crosslinking sites introduced by Cu@MSNMA form a stable porous network structure, achieving structural and mechanical biomimicry to provide necessary support for bone defects; (iii) The elemental biomimicry of Si and Cu in Cu@MSNMA achieves efficient osteogenic induction. The effect of different proportions of Cu@MSNMA on the physical properties of the composite hydrogels was investigated to determine the optimal proportion. The results indicated that the mechanical properties of hydrogel were enhanced with the increasing Cu@MSNMA mass ratio. Notably, 5% NPs/GelMA/gelatin hydrogel exhibited excellent mechanical property compared to the GelMA/gelatin hydrogel. In vitro and <i>vivo</i> cellular experiments demonstrated a significant enhancement in antibacterial and osteogenic induction with Cu@MSNMA addition. In conclusion, the proposed nanocomposite hydrogel with biomimetic components and ion-regulating properties can serve as a multifunctional scaffold, offering antimicrobial properties for infected bone regeneration, and guide for future research in bone regeneration and three-dimensional printing.</p></div>","PeriodicalId":614,"journal":{"name":"Journal of Bionic Engineering","volume":"23 1","pages":"311 - 325"},"PeriodicalIF":5.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}