Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review.

IF 2.4 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Head & Face Medicine Pub Date : 2024-03-28 DOI:10.1186/s13005-024-00421-5
Saeideh Ghasemi, Bardia Mortezagholi, Emad Movahed, Sahar Sanjarian, Arshin Ghaedi, Amirhossein Mallahi, Aida Bazrgar, Monireh Khanzadeh, Brandon Lucke-Wold, Shokoufeh Khanzadeh
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Abstract

Background: We conducted this systematic review to compile the evidence for the role of neutrophil to lymphocyte ratio (NLR) in odontogenic infection (OI) and to determine whether NLR is elevated in patients with OI. This was done to aid physicians in better understanding this condition for clinical management.

Methods: The search was conducted on PubMed, Scopus, and Web of Science libraries on March 30, 2023. Two reviewers independently screened the studies using Endnote software. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies.

Results: A total of nine studies were included in the review. Among patients with OI, positive and statistically significant correlations of NLR were seen with more severe disease, a prolonged hospital stay, postoperative requirement of antibiotics, and total antibiotic dose needed. In the receiver operating characteristics (ROC) analysis, the optimum cut-off level of NLR was 5.19 (specificity: 81, sensitivity: 51). In addition, NLR was correlated with preoperative fever (p = 0.001). Among patients with Ludwig's Angina, NLR could predict disease severity and length of stay in the hospital (p = 0.032 and p = 0.033, respectively). In addition, the relationship between the NLR and mortality was statistically significant (p = 0.026, specificity of 55.5%, and sensitivity of 70.8%). Among patients with severe oral and maxillofacial space infection, a positive correlation was found between IL-6 and CRP with NLR (rs = 0.773, P = 0.005 and rs = 0.556, P = 0.020, respectively). Also, a higher NLR was considered an essential predictor of organ involvement (P = 0.027) and the number of complications (P = 0.001). However, among diabetes mellitus (DM) patients afflicted with submandibular abscesses, NLR had no association with therapeutic response.

Conclusions: Many people around the world suffer from OI, and a cheap and fast biomarker is needed for it. Interestingly, inflammation plays a role in this infection, and elevated NLR levels can be a good biomarker of inflammation and, as a result, for OI progression.

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牙源性感染中的中性粒细胞与淋巴细胞比率:系统综述。
背景:我们进行了这项系统性综述,旨在汇编中性粒细胞与淋巴细胞比值(NLR)在牙源性感染(OI)中作用的证据,并确定 OI 患者的 NLR 是否升高。这样做是为了帮助医生更好地了解这种情况,以便进行临床管理:方法:2023 年 3 月 30 日在 PubMed、Scopus 和 Web of Science 图书馆进行了检索。两名审稿人使用 Endnote 软件独立筛选了这些研究。采用纽卡斯尔-渥太华量表(NOS)评估研究质量:结果:共有九项研究被纳入综述。在 OI 患者中,NLR 与病情较重、住院时间较长、术后抗生素需求量和所需抗生素总剂量呈统计学意义上的正相关。在接受者操作特征(ROC)分析中,NLR 的最佳临界值为 5.19(特异性:81,敏感性:51)。此外,NLR 与术前发热相关(p = 0.001)。在路德维希心绞痛患者中,NLR 可预测疾病严重程度和住院时间(分别为 p = 0.032 和 p = 0.033)。此外,NLR 与死亡率之间的关系具有统计学意义(p = 0.026,特异性为 55.5%,敏感性为 70.8%)。在严重口腔颌面部间隙感染患者中,IL-6 和 CRP 与 NLR 呈正相关(分别为 rs = 0.773,P = 0.005 和 rs = 0.556,P = 0.020)。此外,较高的 NLR 被认为是器官受累(P = 0.027)和并发症数量(P = 0.001)的重要预测指标。然而,在患有颌下脓肿的糖尿病(DM)患者中,NLR与治疗反应无关:全世界有许多人患有口腔颌面部脓肿,因此需要一种廉价、快速的生物标志物。有趣的是,炎症在这种感染中起着一定的作用,而 NLR 水平的升高可以作为炎症的良好生物标志物,因此也是 OI 进展的良好生物标志物。
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来源期刊
Head & Face Medicine
Head & Face Medicine DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.70
自引率
3.30%
发文量
32
审稿时长
>12 weeks
期刊介绍: Head & Face Medicine is a multidisciplinary open access journal that publishes basic and clinical research concerning all aspects of cranial, facial and oral conditions. The journal covers all aspects of cranial, facial and oral diseases and their management. It has been designed as a multidisciplinary journal for clinicians and researchers involved in the diagnostic and therapeutic aspects of diseases which affect the human head and face. The journal is wide-ranging, covering the development, aetiology, epidemiology and therapy of head and face diseases to the basic science that underlies these diseases. Management of head and face diseases includes all aspects of surgical and non-surgical treatments including psychopharmacological therapies.
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