Radiation levels outside a patient undergoing177Lu-PSMA radioligand therapy.

IF 1.4 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Journal of Radiological Protection Pub Date : 2024-04-04 DOI:10.1088/1361-6498/ad3835
Huan Li, Haikuan Liu, Weiyuan Zhang, Xin Lin, Zhiling Li, Weihai Zhuo
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Abstract

Understanding the spatial distribution of radiation levels outside of a patient undergoing177Lu radioligand therapy is not only helpful for conducting correct tests for patient release, but also useful for estimation of its potential exposure to healthcare workers, caregivers, family members, and the general public. In this study, by mimicking the177Lu-labeled prostate-specific membrane antigen radioligand therapy for prostate cancers in an adult male, the spatial distribution of radiation levels outside of the phantom was simulated based on the Monte Carlo software of Particle and Heavy Ion Transport System, and verified by a series of measurements. Moreover, the normalized dose rates were further formulized on the three transverse planes representing the heights of pelvis, abdomen and chest. The results showed that the distributions of radiation levels were quite complex. Multi-directional and multi-height measurements are needed to ensure the external dose rate to meet the release criteria. In general, the radiation level was higher at the horizontal plane where the source was located, and the levels in front and behind of the body were higher than those of the left and right sides at the same height. The ratio of simulated dose rates to measured ones ranged from 0.82 to 1.19 within 1 m away from the body surface in all directions. Based on the established functions, the relative root mean square deviation between the calculated and simulated values were 0.21, 0.25 and 0.23 within a radius of 1 m on the pelvis, abdomen and chest transverse planes, respectively. It is expected that the results of this study would be helpful for guiding the test of extracorporeal radiation to determine the patient's release, and of benefit to estimate the radiation exposure to others.

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接受 177Lu-PSMA 放射性配体治疗的患者体外辐射水平。
了解接受 177Lu 放射性配体治疗的患者体外辐射水平的空间分布情况,不仅有助于对患者进行正确的释放测试,还有助于估算其对医护人员、护理人员、家庭成员和公众的潜在照射。在本研究中,通过模拟成年男性前列腺癌的 177Lu-PSMA 放射性配体治疗,基于 PHITS 的蒙特卡罗软件模拟了模型外辐射水平的空间分布,并通过一系列测量进行了验证。此外,还进一步计算了代表骨盆、腹部和胸部高度的三个横向平面上的归一化剂量率。结果表明,辐射水平的分布相当复杂。为确保外照射剂量率符合释放标准,需要进行多方位和多高度测量。一般来说,辐射源所在水平面的辐射水平较高,在相同高度下,人体前后的辐射水平高于左右两侧。在距人体表面 1 米范围内,模拟剂量率与实测剂量率之比介于 0.82 与 1.19 之间。根据已建立的函数,在骨盆、腹部和胸部横向平面 1 米半径范围内,计算值与模拟值的相对均方根偏差(RRMSD)分别为 0.21、0.25 和 0.23。预计这项研究的结果将有助于指导体外辐射测试,以确定患者的释放情况,并有益于估算其他人受到的辐射量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Radiological Protection
Journal of Radiological Protection 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
2.60
自引率
26.70%
发文量
137
审稿时长
18-36 weeks
期刊介绍: Journal of Radiological Protection publishes articles on all aspects of radiological protection, including non-ionising as well as ionising radiations. Fields of interest range from research, development and theory to operational matters, education and training. The very wide spectrum of its topics includes: dosimetry, instrument development, specialized measuring techniques, epidemiology, biological effects (in vivo and in vitro) and risk and environmental impact assessments. The journal encourages publication of data and code as well as results.
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