Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells.

Cell metabolism Pub Date : 2024-05-07 Epub Date: 2024-03-26 DOI:10.1016/j.cmet.2024.03.013
Cegui Hu, Wen Qiao, Xiang Li, Zhi-Kun Ning, Jiang Liu, Sumiya Dalangood, Hanjun Li, Xiang Yu, Zhen Zong, Zhenke Wen, Jun Gui
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肿瘤分泌的 FGF21 可通过重新连接 CD8+T 细胞的胆固醇代谢来发挥免疫抑制作用。
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