A study of scarless wound healing through programmed inflammation, proliferation and maturation using a redox balancing nanogel

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part A Pub Date : 2024-03-28 DOI:10.1002/jbm.a.37712

Monojit Das, Susmita Mondal, Ria Ghosh, Soumendra Darbar, Lopamudra Roy, Anjan Kumar Das, Debasish Pal, Siddhartha Sankar Bhattacharya, Asim Kumar Mallick, Jayanta Kumar Kundu, Samir Kumar Pal

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Abstract

In the study, we have shown the efficacy of an indigenously developed redox balancing chitosan gel with impregnated citrate capped Mn₃O₄ nanoparticles (nanogel). Application of the nanogel on a wound of preclinical mice model shows role of various signaling molecules and growth factors, and involvement of reactive oxygen species (ROS) at every stage, namely hemostasis, inflammation, and proliferation leading to complete maturation for the scarless wound healing. While in vitro characterization of nanogel using SEM, EDAX, and optical spectroscopy reveals pH regulated redox buffering capacity, in vivo preclinical studies on Swiss albino involving IL-12, IFN-γ, and α-SMA signaling molecules and detailed histopathological investigation and angiogenesis on every stage elucidate role of redox buffering for the complete wound healing process.

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利用氧化还原平衡纳米凝胶通过程序化炎症、增殖和成熟实现无疤痕伤口愈合的研究。

在这项研究中，我们展示了一种自主开发的氧化还原平衡壳聚糖凝胶与浸渍柠檬酸盐封端 Mn3O4 纳米粒子（纳米凝胶）的功效。纳米凝胶在临床前小鼠模型伤口上的应用显示了各种信号分子和生长因子的作用，以及活性氧（ROS）在止血、炎症和增殖等各个阶段的参与，从而使无疤痕伤口愈合完全成熟。利用 SEM、EDAX 和光学光谱对纳米凝胶进行的体外表征揭示了 pH 值调节的氧化还原缓冲能力，而在瑞士白鼠身上进行的涉及 IL-12、IFN-γ 和 α-SMA 信号分子的体内临床前研究以及每个阶段的详细组织病理学调查和血管生成情况则阐明了氧化还原缓冲在整个伤口愈合过程中的作用。

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.