Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-08-01 Epub Date: 2024-03-28 DOI:10.1007/s10522-024-10100-2
Hye-Yeon Lee, Ji-Hyeon Lee, Jisun Baek, Kyung A Cho, Kyung-Jin Min
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Abstract

Piperine, a dietary phytochemical isolated from the Piper species, has been used as a natural medicine for pain, flu, and fever in ancient China and India. Although the health benefits of piperine have been widely studied, research on its effect on aging is limited. This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resistance to environmental stress. Log-rank tests, Shapiro-Wilk test, F-test, t-test, or Wilcoxon rank sum test were used to analyze the data. Piperine failed to change the lifespan and body weight, but increased the fecundity and decreased the feeding rate in one-week-old flies. However, when piperine was fed to 30-day-old flies, it increased the lifespan of male flies and the fecundity and feeding rate of female flies. These results indicate that piperine can improve the health of aged flies. The findings suggest that piperine has age-dependent and sex-specific anti-aging effects in fruit flies.

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胡椒碱能改善黑腹果蝇的健康寿命,并具有年龄和性别特异性效应。
胡椒碱是从胡椒属植物中分离出来的一种膳食植物化学物质,在古代中国和印度一直被用作治疗疼痛、流感和发烧的天然药物。虽然胡椒碱对健康的益处已被广泛研究,但有关其对衰老的影响的研究却很有限。本研究旨在确定胡椒碱是否有可能缓解果蝇(黑腹果蝇)与衰老有关的变化,果蝇是研究衰老的极佳模式生物。实验使用刚羽化或羽化 30 天的黑腹果蝇野生型品系广白进行。将胡椒碱溶解在 99% 的乙醇中,并以 10、35、70 或 100 μM 的最终浓度添加到蔗糖-酵母培养基中。该研究考察了补充胡椒碱对黑腹蝇蛆寿命及其他生理功能的影响,如繁殖力、摄食、脂质含量和对环境应激的抵抗力。数据分析采用对数秩检验、Shapiro-Wilk检验、F检验、t检验或Wilcoxon秩和检验。胡椒碱未能改变一周龄苍蝇的寿命和体重,但提高了繁殖力并降低了摄食率。然而,给30日龄的苍蝇喂食胡椒碱后,雄蝇的寿命、雌蝇的繁殖力和摄食率都有所提高。这些结果表明,胡椒碱可以改善老龄苍蝇的健康状况。研究结果表明,胡椒碱对果蝇具有年龄依赖性和性别特异性抗衰老作用。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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