Association between cytomegalovirus infection and neurological disorders: A systematic review.

IF 9 2区 医学 Q1 VIROLOGY Reviews in Medical Virology Pub Date : 2024-05-01 DOI:10.1002/rmv.2532
Samira Sanami, Shahnam Shamsabadi, Amir Dayhimi, Mohammad Pirhayati, Sajjad Ahmad, Ahmadreza Pirhayati, Marjan Ajami, Sara Hemati, Masoud Shirvani, Ahmad Alagha, Davood Abbarin, Akram Alizadeh, Hamidreza Pazoki-Toroudi
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Abstract

Cytomegalovirus (CMV) belongs to the Herpesviridae family and is also known as human herpesvirus type 5. It is a common virus that usually doesn't cause any symptoms in healthy individuals. However, once infected, the virus remains in the host's body for life and can reactivate when the host's immune system weakens. This virus has been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease, Autism spectrum disorder, Huntington's disease (HD), ataxia, Bell's palsy (BP), and brain tumours, which can cause a wide range of symptoms and challenges for those affected. CMV may influence inflammation, contribute to brain tissue damage, and elevate the risk of moderate-to-severe dementia. Multiple studies suggest a potential association between CMV and ataxia in various conditions, including Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, acute cerebellitis, etc. On the other hand, the evidence regarding CMV involvement in BP is conflicting, and also early indications of a link between CMV and HD were challenged by subsequent research disproving CMV's presence. This systematic review aims to comprehensively investigate any link between the pathogenesis of CMV and its potential role in neurological disorders and follows the preferred reporting items for systematic review and meta-analysis checklist. Despite significant research into the potential links between CMV infection and various neurological disorders, the direct cause-effect relationship is not fully understood and several gaps in knowledge persist. Therefore, continued research is necessary to gain a better understanding of the role of CMV in neurological disorders and potential treatment avenues.

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巨细胞病毒感染与神经系统疾病之间的关系:系统综述。
巨细胞病毒(CMV)属于疱疹病毒科,又称人类疱疹病毒 5 型。它是一种常见的病毒,通常不会对健康人造成任何症状。但是,一旦感染,病毒就会终生留在宿主体内,当宿主的免疫系统变弱时,病毒就会重新激活。这种病毒与多种神经系统疾病有关,包括阿尔茨海默病、帕金森病、自闭症谱系障碍、亨廷顿氏病(HD)、共济失调、贝尔氏麻痹(BP)和脑肿瘤,会给患者带来各种症状和挑战。CMV 可能会影响炎症反应,导致脑组织损伤,并增加中度至重度痴呆症的风险。多项研究表明,在吉兰-巴雷综合征、慢性炎症性脱髓鞘性多发性神经病、急性小脑炎等多种疾病中,CMV 与共济失调之间存在潜在联系。另一方面,有关 CMV 与 BP 有关的证据却相互矛盾,而且早期关于 CMV 与 HD 之间存在联系的说法也受到了后来证明 CMV 不存在的研究的质疑。本系统综述旨在全面研究 CMV 的发病机制与其在神经系统疾病中的潜在作用之间的任何联系,并遵循系统综述和荟萃分析清单的首选报告项目。尽管对 CMV 感染与各种神经系统疾病之间的潜在联系进行了大量研究,但直接的因果关系尚未完全明了,而且仍存在一些知识空白。因此,有必要继续开展研究,以便更好地了解 CMV 在神经系统疾病中的作用以及潜在的治疗途径。
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来源期刊
Reviews in Medical Virology
Reviews in Medical Virology 医学-病毒学
CiteScore
21.40
自引率
0.90%
发文量
88
期刊介绍: Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.
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