The CEA/PCI ratio is a superior prognosticator than mCOREP for colorectal cancer patients with peritoneal carcinomatosis

IF 1.4 Q3 SURGERY Surgery open science Pub Date : 2024-03-28 DOI:10.1016/j.sopen.2024.03.014

Phelopatir Anthony MD, MS , Shoma Barat BSc, MSc , Nima Ahmadi MBBS, FRACS , David Lawson Morris MBChB, FRACS

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Abstract

Background

The CEA/PCI ratio, which evaluates tumour marker and burden, has been demonstrated as a prognosticator for patients with colorectal cancer with peritoneal carcinomatosis. The aim of this study was to compare the CEA/PCI ratio with the Modified Colorectal Peritoneal Score (mCOREP) for overall survival (OS) and recurrence free survival (RFS). There is no literature currently comparing both markers for RFS.

Methods

Data was collected retrospectively for patients undergoing CRS and hyperthermic intraperitoneal chemotherapy (HIPEC) at the Peritonectomy Unit at St. George Hospital, NSW from January 2015 to December 2021.

Results

From 187 patients, an increase in CEA/PCI ratio was associated with reduced OS (p < 0.01) and RFS (p < 0.01), whereas mCOREP score did not demonstrate such association with OS (p = 0.5) nor RFS (p = 0.4). However, CEA/PCI ratio greater than the median of 0.63 was correlated with an increased OS (p = 0.01), whereas the mCOREP greater than the median of 4 correlated with reduced OS (p < 0.01). Median mCOREP also demonstrated association with reduced RFS in patients with PCI <15 (p = 0.03), whereas CEA/PCI ratio above 0.63 demonstrated association with reduced RFS in patients with PCI ≥ 15 (p = 0.02).

Conclusion

The CEA/PCI ratio is more associated with OS and RFS in patients with colorectal cancer with peritoneal carcinomatosis, when compared with mCOREP. CEA/PCI ratio above 0.63 was correlated with increased OS, whereas mCOREP above 4 is correlated with reduced OS. CEA/PCI ratio above 0.63 demonstrated reduced RFS for patients with higher PCIs. By contrast, mCOREP >4 illustrated reduced RFS in patients with lower PCIs.

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与 mCOREP 相比，CEA/PCI 比值是腹膜癌变结直肠癌患者的更佳预后指标

背景评估肿瘤标记物和负担的 CEA/PCI 比值已被证明是伴有腹膜癌肿的结直肠癌患者的预后指标。本研究旨在比较 CEA/PCI 比值与改良结直肠腹膜评分（mCOREP）对总生存期（OS）和无复发生存期（RFS）的影响。目前还没有文献对这两种指标的 RFS 进行比较。方法回顾性收集了 2015 年 1 月在新南威尔士州圣乔治医院腹膜切除术室接受 CRS 和腹腔热化疗 (HIPEC) 的患者数据。结果187例患者中，CEA/PCI比值的增加与OS（p <0.01）和RFS（p <0.01）的降低有关，而mCOREP评分与OS（p = 0.5）和RFS（p = 0.4）不相关。然而，CEA/PCI 比率大于中位数 0.63 与 OS 增加相关（p = 0.01），而 mCOREP 大于中位数 4 与 OS 减少相关（p < 0.01）。结论与 mCOREP 相比，CEA/PCI 比值与腹膜癌变的结直肠癌患者的 OS 和 RFS 更相关。CEA/PCI 比值高于 0.63 与 OS 增加相关，而 mCOREP 高于 4 则与 OS 减少相关。CEA/PCI比值高于0.63表明PCI较高的患者RFS降低。相比之下，mCOREP >4则表明PCI较低的患者RFS降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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