Effectiveness of COVID-19 vaccination against school absenteeism in children and adolescents hospitalized with COVID-19

IF 4.5 3区医学 Q2 IMMUNOLOGY Vaccine Pub Date : 2024-03-30 DOI:10.1016/j.vaccine.2024.03.075

Helena C. Maltezou , Stavroula Kontogianni , Elisavet Michailidou , Eleni Vergadi , Theodoros V. Giannouchos , Evangelia Steletou , Nikolaos V. Sipsas , Emmanouil Galanakis , George A. Syrogiannopoulos , Emmanuel Roilides

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Abstract

Background

COVID-19 vaccination has been recommended for children to protect them and to enable in-person educational and social activities.

Methods

We estimated COVID-19 vaccination effectiveness (VE) against school absenteeism in children 5–17 years old hospitalized from September 1, 2021 through May 31, 2023. Full vaccination was defined as two vaccine doses.

Results

We studied 231 children admitted to hospital with COVID-19, including 206 (89.2 %) unvaccinated/partially vaccinated and 25 (10.8 %) fully vaccinated. Unvaccinated/partially vaccinated children were absent from school for longer periods compared to fully vaccinated children (median absence: 14 versus 10 days; p-value = 0.05). Multivariable regression showed that full COVID-19 vaccination was associated with fewer days of absence compared to no/partial vaccination on average (adjusted relative risk: 0.77; 95 % CI: 0.61 to 0.98). COVID-19 VE was 50.7 % (95 % CI: −11.3 % to 78.2 %) for school absenteeism above the median duration of absenteeism.

Conclusions

Full COVID-19 vaccination conferred protection against school absenteeism in hospitalized school-aged children with COVID-19.

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接种 COVID-19 疫苗对预防因 COVID-19 而住院的儿童和青少年旷课的效果。

背景：我们建议儿童接种 COVID-19 疫苗，以保护他们并使他们能够亲自参加教育和社会活动：我们估算了2021年9月1日至2023年5月31日期间住院的5-17岁儿童接种COVID-19疫苗对缺课的有效性（VE）。完全接种定义为接种两剂疫苗：我们对 231 名接种 COVID-19 的住院儿童进行了研究，其中包括 206 名（89.2%）未接种/部分接种的儿童和 25 名（10.8%）完全接种的儿童。与完全接种疫苗的儿童相比，未接种疫苗/部分接种疫苗的儿童缺课时间更长（缺课中位数：14 天对 10 天；P 值 = 0.05）。多变量回归结果表明，与未接种/部分接种相比，接种 COVID-19 疫苗可减少平均缺课天数（调整后相对风险：0.77；95 % CI：0.61 至 0.98）。在缺勤时间超过中位数的情况下，COVID-19 VE 为 50.7 %（95 % CI：-11.3 % 至 78.2 %）：结论：接种COVID-19疫苗可预防住院学龄儿童因接种COVID-19疫苗而缺课。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.