Causal relationship between air pollution and chronic obstructive pulmonary disease in European and East Asian populations: a Mendelian randomization study.

IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2024-11-01 Epub Date: 2024-04-02 DOI:10.1080/09603123.2024.2334781
Mengting Sun, Ming Gao, Manjun Luo, Tingting Wang, Xiaorui Ruan, Qian Chen, Jiabi Qin
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Abstract

Epidemiologic studies have suggested a possible association between air pollution and chronic obstructive pulmonary disease (COPD), but it is controversial and difficult to draw causal inferences. Five methods were adopted to evaluate the causal relationship between air pollution and COPD in European and East Asian populations by using MR Analysis. A statistically significant causal relationship between PM2.5 and COPD was observed in the European population (OR: 2.34; 95% CI: 1.06-5.05; p = 0.033). Statistical significance remained after adjustment for confounding factors (adjusted OR: 2.28; 95% CI: 1.01-5.20; p = 0.048). In East Asian populations, PM2.5 absorbance, a proxy for black carbon, was statistically associated with COPD (OR: 1.41; 95% CI: 1.09-1.81; p = 0.007). We did not adjust for confounders in East Asian populations, as the association was independent of known confounders (e.g. smoking, respiratory tract infections, etc.). In conclusion, increased concentrations of PM2.5 and PM2.5 absorbance were associated with an increased risk of COPD.

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欧洲和东亚人群中空气污染与慢性阻塞性肺病之间的因果关系:孟德尔随机研究。
流行病学研究表明,空气污染与慢性阻塞性肺病(COPD)之间可能存在关联,但目前尚存在争议,难以得出因果关系推论。本研究采用五种方法,通过磁共振分析评估欧洲和东亚人群中空气污染与慢性阻塞性肺病之间的因果关系。在欧洲人群中观察到 PM2.5 与慢性阻塞性肺病之间存在统计学意义上的因果关系(OR:2.34;95% CI:1.06-5.05;p = 0.033)。在对混杂因素进行调整后,统计意义仍然存在(调整后 OR:2.28;95% CI:1.01-5.20;p = 0.048)。在东亚人群中,代表黑碳的 PM2.5 吸收率与慢性阻塞性肺病有统计学关联(OR:1.41;95% CI:1.09-1.81;p = 0.007)。我们没有调整东亚人群的混杂因素,因为这种关联与已知的混杂因素(如吸烟、呼吸道感染等)无关。总之,PM2.5浓度和PM2.5吸光度的增加与慢性阻塞性肺病风险的增加有关。
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来源期刊
International Journal of Environmental Health Research
International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.10%
发文量
134
审稿时长
>12 weeks
期刊介绍: International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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