International Journal of Environmental Health Research最新文献

Perinatal exposures to the environmental estrogen bisphenol A (BPA) are associated with increased asthma prevalence. We tested the hypothesis that perinatal BPA exposure transgenerationally enhances allergic asthma development through the bromodomain-containing protein 4 (BRD4) - zinc finger HHC-1 (ZDHHC1) - stimulators of IFN genes (STING) axis. Female BALB/c mice (F0) were exposed to 10 μg/mL BPA in their drinking water during pregnancy until F1 pups were weaned. Pups were sensitized with low doses of ovalbumin (OVA) on postnatal day 4 (PND 4) and 1% OVA inhaler on PND 18-20. Asthma phenotype was assessed on PND 22. Non-sensitized female pups were bred with non-exposed male mice at 8 weeks of age. Subsequent pups were sensitized, and asthma phenotypes were examined for four generations (F1-F4). Maternal BPA exposure significantly enhanced airway hyperresponsiveness, eosinophilic inflammation, and allergen-specific IgE production in F1-3 pups. Further, treatment of F0 dams with STING inhibitor C-176 yielded pups with decreased response to sensitization. Thus, prenatal exposure to environmental estrogens such as BPA may promote development of experimental asthma through the BRD4-ZDHHC1-STING axis, causing immune alterations with multigenerational effects.

Studies on the effect of ambient temperature on the number of hospitalizations for cardiovascular diseases in rural Northwest China are rare, and there is a gap in related studies in Wuwei, a less developed city located in Northwest China. We collected hospitalization data from patients with cardiovascular diseases from the new Rural Cooperative Medical Insurance Scheme in Wuwei and meteorological data from the Gansu Provincial Meteorological Bureau and investigated the effect of ambient temperature on the number of hospitalizations for cardiovascular diseases in rural Wuwei, by means of distributed lag nonlinear models (DLNMs). A total of 53,642 patients with cardiovascular diseases were included from 1 January 2011, to 31 December 2015. The damaging effect of low temperature gradually increased with increasing lag time, and the damaging effect of high temperature reached its maximum on the same day (lag0); the heat effect caused more damage than the cold effect; and for both low and high temperatures, the relative risk (RR) was greater among female and elderly patients than among male and adult patients. This study may provide a theoretical basis for relevant departments to formulate meteorological policies to protect the health of susceptible people.

The widespread use of virtual audits has transformed the assessment of urban design attributes by eliminating the necessity for on-site visits. However, there remains a lack of virtual audit tools specifically designed for evaluating urban parks in dense urban environments. This study aims to (1) adapt the Audit Tool for Activity-friendly Parks in Dense Urban Areas (TAPS) into a remote audit tool (R-TAPS), and (2) evaluate its reliability and validity. Trained auditors used R-TAPS to conduct remote audits of urban parks (n = 53) in Tokyo, with on-site audits for a subset (n = 25). Kappa statistics and percent agreement assessed inter-rater reliability, and intra-class correlation coefficient (ICC) verified convergent validity. R-TAPS showed moderate to almost perfect agreement in 89% of the items. Remote and on-site audits exhibited a high positive correlation (ICC = 0.73). R-TAPS offers a reliable tool for virtually evaluating urban parks to promote physical activity in dense urban settings.

In this report, Castanea sativa shell extracts have been investigated for their activity against Herpes Virus type 2 (HSV-2). Among four organic extracts only 75% ethanol extract demonstrated activity against HSV-2 with a 50% inhibitory concentration of 6.45 μg/mL. The study of the mechanism underlying the antiviral activity demonstrated this extract strongly inhibits HSV-2 by direct contact and moderately protects the cell from virus recognition and binding. The active compound has been identified as oleuropein by HPLC-DAD-ESI-MSⁿ. This compound which is widely known in the Oleaceae family has been identified in the chestnut shells for the first time. The in vitro results of the mechanism underlying anti HSV-2 action were confirmed by an in silico study which revealed a strong binding free energy of -9.08 kcal/mol between oleuropein and the glycoprotein D of HSV-2. In summary, our findings suggest that C. sativa shells may constitute a promising natural source of anti-HSV-2 agents.

This study investigated the relationship between urban park size and community mental health, focusing on neighborhood crime risk as a mediator. Data were collected for 989 urban parks in Alabama, USA, from the Trust for Public Land's ParkServe database and relevant Alabama cities' Parks and Recreation Department websites. Park size was measured using Geographic Information Systems. The relative risks of various crime types, including violent and property crimes, were provided by the Environmental Systems Research Institute. Community mental health data from the PLACES database were used to evaluate the prevalence of poor mental health in different communities. Guided by the Stress Reduction Theory, we used mediation analysis to explore whether crime risk mediated the relationship between park size and mental health outcomes. Results indicated that the effect of larger park sizes on reducing poor mental health was fully mediated by the indirect pathway through reduced crime risk, though park sizes alone were not significantly directly associated with a lower prevalence of poor mental health. By allocating resources to create and maintain high-quality urban neighborhood parks, policymakers can foster safer environments that contribute to improved mental health across communities, and, ultimately, build essential infrastructure to support the public's mental well-being.

The objective of this research was to investigate the phenolic profile and some biological properties of the leaves of Euphorbia bupleuroides subsp. luteola grown wild in Algeria, still unexplored. The leaves were subjected to extraction with 80% MeOH using simple maceration (SM) and ultrasound-assisted maceration (UM) to establish the most efficient conditions for the recovery of phenolic compounds. The study of antioxidant potential suggested that SM and UM extracts displayed a superimposable activity both in the DPPH test and in the reducing power assay. On the other hand, in the Fe2+ chelating activity assay, SM was more active than UM. SM extract prevented damage induced by β-amyloid protein (Aβ) being more effective against ROS generated after treatment with Aβ. In addition, SM exhibited later protection against malondialdehyde. In conclusion, it is possible to state that simple maceration represents an effective technique for the recovery of compounds with antioxidant and neuroprotective properties from E. bupleuroides subsp. luteola leaves.

Food neophobia, the fear of trying new foods, may reduce dietary variety, posing risks for nutritional deficiencies. This study examined the links between food neophobia, dietary quality, and diversity among Turkish young adults. A cross-sectional study with 949 participants (470 males, 479 females) aged 18-35 years used the Food Neophobia Scale (FNS) and a 24-h dietary recall to assess food intake. Dietary diversity score (DDS), food variety score (FVS), mean adequacy ratio (MAR), and healthy eating index (HEI-2015) were calculated. The mean neophobia score was 37.07 ± 12.17, with 13.4% high, 67.9% average, and 18.8% low neophobia. The average neophobia group had higher diet quality scores (MAR, DDS, FVS) than the low and high neophobia groups (p < 0.01). Positive relationships with food neophobia were found for niacin, calcium, zinc, plant protein, and cholesterol (p < 0.05). These findings suggest that food neophobia may affect dietary quality variably, with certain micronutrients positively linked to it.

Urban stormwater management failures lead to floodingg. Potentially toxic elements (PTE) are commonly found in floods exposing population and ecosystems. Flooding is a persistent problem in the city of Hermosillo, Sonora thus PTE concentrations were determined, including threats to receiving ecosystems and population. The PTE concentrations were determined by MP-AES and compared to national and international guidelines. The non-carcinogenic and carcinogenic health risks were evaluated for adults and children following the EPA protocols. Al, Fe and Zn showed the highest concentrations. The concentrations exceeded consulted guideline criteria. PTE groups were identified relating to their sources and origin: (1) Fe, Mn, Ti and Al, (2) Cu, Cd and Cr, (3) Pb, Ni and Zn. Non-carcinogenic health effects and cancer risk were observed in the analyzed floodwater indicating that management measures should be taken to protect the flood-affected population.

Background: Household cleaning agents promote hygiene along with causing respiratory effects, especially pediatric asthma. This systematic review quantified the association between exposure to household cleaning agents and pediatric asthma.

Method: Five databases were searched. Data were analyzed qualitatively and quantitatively. RevMan 5.4 calculated odds ratios (OR) with 95% confidence intervals (CI), and a funnel plot assessed publication bias. The Mixed Methods Appraisal Tool (MMAT) and GRADE framework assessed methodological quality and certainty respectively.

Results: Sixteen studies met the eligibility criteria. Meta-analysis showed a significant association between the use of household cleaning agents and pediatric asthma (OR 2.90 (95% CI: 2.13-3.95; p < 0.01, I² = 98%). Exposure stages also showed significant (p < 0.01) association with household cleaning agents (OR 2.92 (95% CI: 2.12-4.03, I² = 98%). No publication bias or high risk of bias was found.

Conclusion: A strong association between exposure to household cleaning agents and an increased risk of pediatric asthma was found. .

This study presents the results of an environment investigation and monitoring of chlorpyrifos contamination in the vicinity of a pesticide enterprise in East China, focusing on its relation to environmental and human health risks. The impact zone of chlorpyrifos is particularly pronounced within approximately 2 km of the enterprise. The highest levels of outdoor dust were observed in SP1, which is closest to the enterprise. The individual health risk of exposure to chlorpyrifos through different media - such as indoor air, rice, vegetables, drinking water and indoor dust - was assessed following the procedure defined by the USEPA. The non-carcinogenic risks to both adults and children do not exceed the permissible standard of 1, suggesting no non-carcinogenic risks due to chlorpyrifos exposure. However, the average daily dose calculated by exposure assessment model shows that children are exposed to higher doses of chlorpyrifos compared to adults due to their lifestyle habits and play patterns.