International Journal of Environmental Health Research最新文献

英文中文

Antioxidants from Rubus idaeus leaves: LC-MS/MS chemical profiling, in vitro antiglycation, α-glucosidase and α-amylase inhibitory activities. 茜草叶中的抗氧化剂：LC-MS/MS 化学分析、体外抗糖化、α-葡萄糖苷酶和α-淀粉酶抑制活性。

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-18 DOI: 10.1080/09603123.2024.2404248

El Asri Sara,Ben Mrid Reda,Zouaoui Zakia,Chibuye Bitwell,Ennoury Abdelhamid,Kabach Imad,Nhiri Mohamed,Chibi Fatiha

The present study evaluated a range of biological activities of Rubus idaeus leaves, often considered as by-products, in relation to hyperglycemia. The antiglycation potential of this plant has not been previously reported. In this research, the methanolic leaf extract of R. idaeus was assessed for its antioxidant, enzyme inhibitory and antiglycation activities. The bioactive compounds present in the extract were screened using LC-MS/MS. Enzyme inhibitory activities were tested on α-glucosidase and α-amylase, and the antiglycation effect was investigated using BSA-fructose model. The methanolic extract showed a high polyphenolic contents (176.26 ± 2.26 mg GAE/g) and important IC50 values for DPPH (34.79 ± 2.40 µg/mL) and ABTS radical scavenging activities (49.75 ± 2.47 µg/mL). In addition, the plant leaf extract significantly inhibited hyperglycemia-related enzymes in a dose-dependent manner and demonstrated a reduction in fluorescent AGEs, fructosamine, and dicarbonyl compounds. Therefore, R. idaeus cv Maravilla could be an effective source of therapeutics for improving the healthcare outcomes of diabetic patients.

本研究评估了通常被视为副产品的茜草叶与高血糖有关的一系列生物活性。这种植物的抗糖化潜力以前还没有报道过。在这项研究中，我们评估了茜草叶甲醇提取物的抗氧化、酶抑制和抗糖化活性。使用 LC-MS/MS 对提取物中的生物活性化合物进行了筛选。测试了对α-葡萄糖苷酶和α-淀粉酶的酶抑制活性，并使用 BSA-果糖模型研究了抗糖化作用。甲醇提取物显示出较高的多酚含量（176.26 ± 2.26 mg GAE/g），DPPH（34.79 ± 2.40 µg/mL）和 ABTS 自由基清除活性的 IC50 值（49.75 ± 2.47 µg/mL）也很高。此外，该植物叶提取物以剂量依赖的方式明显抑制了与高血糖相关的酶，并减少了荧光 AGEs、果糖胺和二羰基化合物。因此，R. idaeus cv Maravilla 可以作为一种有效的治疗药物来源，改善糖尿病患者的治疗效果。

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引用次数: 0

Effect and interaction of PINK1 genetic polymorphisms and environmental factors on blood pressure in COEs-exposed workers. PINK1 基因多态性和环境因素对接触 COE 的工人血压的影响和相互作用。

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-18 DOI: 10.1080/09603123.2024.2403685

Jing Sun,Yang Chen,Xiangkai Zhao,Zeming Niu,Zhiguang Gu,Zhaofan Yan,Wei Wang

Coke oven emissions (COEs) contain a variety of polycyclic aromatic hydrocarbons (PAHs), which can cause damage to the human cardiovascular system. In addition, myocardial mitochondria are susceptible to damage in hypertensive patients. However, it is not clear whether genetic variation, in single nucleotide polymorphisms (SNPs) in PINK1 affects COEs exposure-induced abnormal blood pressure. We surveyed and tested 518 workers exposed to COEs and statistically analyzed them with SPSS 21.0 software. SBP was greater in the high-exposure group than in the low-exposure group. Generalized linear model analysis showed that the interaction of PINK1 rs3738136 (GA+AA) and COEs had an effect on SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] and DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]. This study is the first to identify the role of PINK1 rs3738136 in COE- induced abnormal blood pressure, and to prove that the abnormal blood pressure of workers is the result of environmental and genetic factors.

焦炉排放物（COEs）含有多种多环芳烃（PAHs），可对人体心血管系统造成损害。此外，高血压患者的心肌线粒体也容易受损。然而，PINK1 的单核苷酸多态性（SNPs）遗传变异是否会影响 COEs 暴露引起的血压异常，目前尚不清楚。我们对 518 名接触 COEs 的工人进行了调查和测试，并使用 SPSS 21.0 软件进行了统计分析。高接触组的 SBP 高于低接触组。广义线性模型分析表明，PINK1 rs3738136 (GA+AA) 与 COEs 的交互作用对 SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] 和 DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]有影响。本研究首次确定了 PINK1 rs3738136 在 COE 诱导的血压异常中的作用，并证明工人的血压异常是环境和遗传因素共同作用的结果。

引用次数: 0

A new perspective on essential tremor: the potential etiologic role of Toxoplasma gondii and Toxocara spp 本质性震颤的新视角：弓形虫和弓形虫的潜在致病作用

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-17 DOI: 10.1080/09603123.2024.2404480

Tuncay Celik, Erman Altunisik, Turkan Mutlu Yar, Tuba Gul, Yeliz Kasko Arici, Ulku Karaman

Our aim was to examine the relationship between Toxoplasma gondii (T. gondii) and Toxocara infection and patients with essential tremor (ET). This study comprised a total of 174 participants, consi...

我们的目的是研究弓形虫（T. gondii）和弓形虫感染与本质性震颤（ET）患者之间的关系。这项研究共有 174 名参与者，其中包含...

引用次数: 0

Association of environmental factors with breast cancer incidence among African American women in Memphis, Tennessee 环境因素与田纳西州孟菲斯市非裔美国妇女乳腺癌发病率的关系

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-13 DOI: 10.1080/09603123.2024.2400702

Namuun Batbaatar, Alana Smith, Chunrong Jia, Abu Mohd Naser, Xichen Mou, Gregory Vidal, Athena Starlard-Davenport

African American (AA) women confront distinct disparities in breast cancer rates, and the impact of their living environment is unclear. This study aimed to examine the association between breast c...

非裔美国人（AA）妇女在乳腺癌发病率方面面临着明显的差异，而她们的生活环境对其影响尚不清楚。本研究的目的是探讨非裔美国人与乳腺癌之间的关系。

引用次数: 0

The ratio of concentration of organic carbon and elemental carbon bound to particulate matter in ambient air: a global systematic review and meta-analysis. 环境空气中与颗粒物结合的有机碳和元素碳的浓度比：全球系统回顾和荟萃分析。

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-10 DOI: 10.1080/09603123.2024.2399207

Yadolah Fakhri,Mansour Sarafraz,Allahbakhsh Javid,Mahboobeh Moradi,Fereshteh Mehri,Rasul Nasiri,Sepideh Saadatmandsepideh

Four hundred and sixty-six references with 625 data reports were included in our study. The high frequency of ratio OC/EC for PM0.1 was observed in 3.92-5.93; PM1 in 1.08-3.08; PM2.5, 2.08-4.08; PM10 in 2.70-4.70 and TSP in 2.66-4.66. The rank order of areas based on the pooled concentration of OC bound to PM2.5 was traffic (17.893 µg/m3) > industrial (10.58 µg/m3) > urban (7.696 µg/m3) > rural (4.08 µg/m3). The rank order of areas based on the pooled (mean) concentration of EC in PM2.5 was traffic (17.893 µg/m3) > industrial (2.65 µg/m3) > Urban (1.48 µg/m3) > rural (1.06 µg/m3). The pooled concentrations of OC and EC bound to PM2.5 in traffic areas were higher than in other areas. Therefore, it is recommended that monitoring and effectively reducing concentration plans are carried out, especially in traffic areas.

我们的研究纳入了 466 篇参考文献，共 625 份数据报告。观察到 PM0.1 的 OC/EC 比值频率较高，为 3.92-5.93；PM1 为 1.08-3.08；PM2.5 为 2.08-4.08；PM10 为 2.70-4.70；TSP 为 2.66-4.66。根据与PM2.5结合的OC集合浓度，各地区的排名顺序为交通（17.893微克/立方米）>工业（10.58微克/立方米）>城市（7.696微克/立方米）>农村（4.08微克/立方米）。根据 PM2.5 中氨基甲酸乙酯的总浓度（平均值），各地区的排名依次为交通（17.893 微克/立方米）>工业（2.65 微克/立方米）>城市（1.48 微克/立方米）>农村（1.06 微克/立方米）。在交通区域，与 PM2.5 结合的 OC 和 EC 的总浓度高于其他区域。因此，建议开展监测和有效降低浓度计划，特别是在交通区域。

引用次数: 0

Disinfection byproducts in US drinking water and cancer mortality. 美国饮用水中的消毒副产物与癌症死亡率。

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-10 DOI: 10.1080/09603123.2024.2400701

Angelico Mendy

Trihalomethanes, the main drinking water disinfection byproducts, may be carcinogenic and are regulated to amaximum total trihalomethanes (TTHM) of 80 µg/l in the US. We aimed to determine whether total and individual trihalomethanes in drinking water across the US are associated with higher cancer mortality in 6,260 adult participants to the National Health and Nutrition Examination Surveys from 1999 to 2008 followed for mortality until 2019 (median: 14.4 years). At baseline, the geometric mean (standard error) of TTHM in drinking water was 9.61 (0.85) µg/l. During follow-up, 873 deaths occurred, including 207 from cancer. In Cox proportional hazards regression adjusted for relevant covariates, drinking water TTHM (HR: 1.45, 95% CI: 1.16-1.82), chloroform (HR: 1.35, 95% CI: 1.12-1.64), and bromodichloromethane (HR: 1.30, 95% CI: 1.05-1.59) were associated with 30% to 45% higher cancer mortality. Therefore, drinking water trihalomethanes, especially chloroform and bromodichloromethane maybe risk factors for cancer mortality.

三卤甲烷是主要的饮用水消毒副产物，可能致癌，美国规定三卤甲烷总含量 (TTHM) 上限为 80 µg/l。我们旨在确定美国各地饮用水中的总三卤甲烷和单个三卤甲烷是否与癌症死亡率的升高有关，我们对 1999 年至 2008 年期间参加全国健康与营养调查的 6260 名成年参与者进行了跟踪调查，以确定他们的死亡率，直至 2019 年（中位数：14.4 年）。基线时，饮用水中 TTHM 的几何平均数（标准误差）为 9.61 (0.85) µg/l。在随访期间，共有 873 人死亡，其中 207 人死于癌症。在对相关协变量进行调整的 Cox 比例危险回归中，饮用水中的三卤甲烷（HR：1.45，95% CI：1.16-1.82）、氯仿（HR：1.35，95% CI：1.12-1.64）和溴二氯甲烷（HR：1.30，95% CI：1.05-1.59）与癌症死亡率增加 30% 至 45% 相关。因此，饮用水中的三卤甲烷，尤其是氯仿和溴二氯甲烷，可能是导致癌症死亡的风险因素。

引用次数: 0

Acrylamide exposure, sex hormones, and pubertal status in Japanese adolescents. 日本青少年接触丙烯酰胺的情况、性激素和青春期状况。

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-10 DOI: 10.1080/09603123.2024.2401578

Chisato Nagata,Keiko Wada,Michiyo Yamakawa,Masaaki Sugino,Tomoka Mori,Jun Ueyama,Yoshio Sumoto

Acrylamide may affect sex hormone levels and the timing of sexual maturation. The present study cross-sectionally examined interrelationship between the urinary metabolite of acrylamide exposure, serum sex hormone levels, and pubertal status in 408 Japanese adolescents aged 13-14 years. Their caregivers completed a questionnaire concerning the health status of their children, including pubertal maturation, and the lifestyles of children and parents. Pubertal status was queried by the Pubertal Development Scale. A major metabolite of acrylamide, N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) in first-void urine samples. In male students, urinary AAMA was significantly inversely associated with testosterone, puberty stage, and facial hair growth after controlling for covariates. Serum testosterone and DHEAS were significantly positively associated with puberty stage. In female students, urinary AAMA was not associated with puberty stage, the indices, or any measured hormones. The data suggest that exposure to acrylamide may impact the pubertal development of boys through the effects on testosterone level.

丙烯酰胺可能会影响性激素水平和性成熟的时间。本研究对 408 名 13-14 岁日本青少年尿液中丙烯酰胺代谢物、血清性激素水平和青春期状况之间的相互关系进行了横断面研究。他们的看护人填写了一份调查问卷，内容涉及子女的健康状况（包括青春期成熟情况）以及子女和父母的生活方式。青春期发育状况通过青春期发育量表进行调查。丙烯酰胺的主要代谢产物 N-乙酰基-S-（2-氨基甲酰乙基）-半胱氨酸（AAMA）在第一次排尿样本中的含量。在男性学生中，尿液中的丙烯酰胺与睾酮、青春期阶段和面部毛发生长显著成反比。血清睾酮和 DHEAS 与青春期阶段呈显著正相关。在女生中，尿液中的 AAMA 与青春期阶段、各项指数或任何测得的激素均无关联。数据表明，接触丙烯酰胺可能会影响睾酮水平，从而影响男孩的青春期发育。

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引用次数: 0

Dose assessment from exposure to uranium and radon in groundwater in Safi province, Morocco. 摩洛哥萨菲省地下水铀和氡暴露剂量评估。

IF 3.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-09 DOI: 10.1080/09603123.2024.2400274

Bouchra Samyh,Abdellatif Nachab,Meryame Jabbade,Abdel-Mjid Nourreddine

In this study we evaluate the uranium and radon concentrations in groundwater from the Province of Safi. The samples were collected from 58 wells across five communes and analyzed using the LR-115 type II detector. Results indicate that uranium concentrations ranged from the Limit of Detection (LLD) to 3.73 µg/l, with a mean of 0.72 µg/l, well below the World Health Organization's safe limit of 30 µg/l. Radon levels varied from LLD to 2.39 Bq/l, with an average of 0.60 Bq/l, also below the United States Environmental Protection Agency's limit of 11 Bq/l. The estimated total annual effective dose due to uranium and radon ranged from 3.47 to 18.84 µSv/y, with an average of 7.54 µSv/y, which is significantly lower than the European Commission's recommended limit of 100 µSv/y. This investigation represents the first study of uranium and radon levels in groundwater in the Province of Safi, providing valuable data for future research and public health.

在这项研究中，我们对萨菲省地下水中的铀和氡浓度进行了评估。样本从五个乡镇的 58 口井中采集，并使用 LR-115 II 型检测器进行分析。结果表明，铀浓度从检测限（LLD）到 3.73 微克/升不等，平均值为 0.72 微克/升，远低于世界卫生组织规定的 30 微克/升的安全限值。氡含量从 LLD 到 2.39 Bq/l，平均为 0.60 Bq/l，也低于美国环境保护局规定的 11 Bq/l。据估计，铀和氡的年总有效剂量为 3.47 至 18.84 µSv/年，平均为 7.54 µSv/年，大大低于欧盟委员会建议的 100 µSv/年的限值。这项调查是对萨菲省地下水中铀和氡含量的首次研究，为今后的研究和公众健康提供了宝贵的数据。

引用次数: 0

Family cleaning behaviors and air treatment equipment significantly affect associations of indoor damp indicators with childhood pneumonia among preschoolers. 家庭清洁行为和空气处理设备对学龄前儿童室内潮湿指标与儿童肺炎的相关性有显著影响。

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-05 DOI: 10.1080/09603123.2024.2398092

Wei Liu, Jing Chang, Nan Zhang, Wangjin Lai, Wenjie Li, Wenming Shi, Jian Wang, Jianhua Wei, Jiao Cai

In this study, based on a cross-sectional study among 9597 preschoolers in Shandong of China, we quantitatively evaluated influences of lifestyle behaviors and air treatment equipment on indoor damp exposures and thus on risks of childhood pneumonia. In the two-level multivariate logistic regression analyses, childhood pneumonia was significantly associated with parent-reported damp clothing/bedding and visible mold spots or damp stains. These associations were weaker among preschoolers from families who frequently opened the child's bedroom windows, frequently cleaned the child's bedroom, and frequently exposed beddings to sunshine (references: not frequently), as well as among preschoolers without usage of air humidifier and air conditioner and with usage of air purifier. Our results indicate that frequently keeping household ventilation and cleanness, and exposing beddings to sunshine, as well using air purifier could decrease the effects of household damp-related exposures on childhood pneumonia, but using air humidifier and air conditioner could increase the effects.

本研究基于对中国山东地区 9597 名学龄前儿童的横断面研究，定量评估了生活行为和空气处理设备对室内潮湿暴露的影响，以及由此对儿童肺炎风险的影响。在两级多变量逻辑回归分析中，儿童肺炎与家长报告的潮湿衣物/床上用品和可见霉斑或潮湿污渍显著相关。在经常打开孩子卧室窗户、经常打扫孩子卧室、经常让床上用品暴露在阳光下（参考：不经常）的家庭，以及不使用空气加湿器和空调和使用空气净化器的学龄前儿童中，这些相关性较弱。我们的研究结果表明，经常保持家居通风和清洁、让床上用品接触阳光以及使用空气净化器可减少家居潮湿对儿童肺炎的影响，但使用空气加湿器和空调则会增加这种影响。

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引用次数: 0

Histone deacetylase inhibitory properties of metabolites from leaves of Quercus pontica K. Koch and its metabolites. Quercus pontica K. Koch叶片及其代谢物的组蛋白去乙酰化酶抑制特性。

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research

Pub Date : 2024-09-05 DOI: 10.1080/09603123.2024.2399210

Gülin Renda, Sezer Sevgi, Michal Šoral, Gamze Bora-Akoğlu, Suat Sari, Özge Çetin, Pelin Zobaroğlu-Özer, Didem Şöhretoğlu

The infusions prepared from some Quercus L. species are used in folk medicine for medicinal purposes and consumed as tea. Quercus pontica K. Koch was selected in this study, for which no phytochemical isolation studies have been performed so far. Quercetin 3-O- β-D-glucopyranoside, kaempferol 3-O-(6""-O-galloyl)-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, kaempferol 3-O-(6"'-coumaroyl-β-D-glucopyranoside, phlorizin, rosmarinic acid, and catechin were isolated from the titled plant for the first time. Some polyphenolic compounds have been shown to inhibit histone deacetylase (HDAC) enzymes. However, there is no study on the any activities of Quercus species in the literature. In this study, we demonstrated that the extract has in vitro pan-HDAC inhibition activity. Through a virtual screening study, the compounds were found to inhibit HDAC7 more strongly than the other HDAC isoforms; therefore, the HDAC7 inhibition activities were studied in vitro. Kaempferol 3-O-β-D-glucopyranoside and kaempferol 3-O-(6'"-coumaroyl-β-D-glucopyranoside) showed the best anti-HDAC7 activity with 37% and 41% inhibition at 500 μM.

从一些柞树树种中提取的浸泡液在民间医学中用于药用目的，并作为茶饮用。本研究选择了迄今为止尚未进行过植物化学分离研究的 Quercus pontica K. Koch。研究首次从该植物中分离出槲皮素 3-O-β-D-Glucopyranoside 、山柰酚 3-O-(6""-O-galloyl)-β-D-Glucopyranoside 、山柰酚 3-O-β-D-Glucopyranoside 、山柰酚 3-O-(6"'-coumaroyl-β-D-Glucopyranoside, phlorizin, 迷迭香酸和儿茶素。一些多酚化合物已被证明能抑制组蛋白去乙酰化酶（HDAC）。然而，文献中还没有关于柞树的任何活性的研究。在这项研究中，我们证明了槲皮提取物具有体外泛 HDAC 抑制活性。通过虚拟筛选研究，我们发现这些化合物对 HDAC7 的抑制作用比对其他 HDAC 同工酶的抑制作用更强；因此，我们对这些化合物的 HDAC7 抑制活性进行了体外研究。山奈酚 3-O-β-D-吡喃葡萄糖苷和山奈酚 3-O-（6'"-香豆酰-β-D-吡喃葡萄糖苷）显示出最佳的抗 HDAC7 活性，在 500 μM 时的抑制率分别为 37% 和 41%。

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