The Effects of Inspiratory Flows, Inspiratory Pause, and Suction Catheter on Aerosol Drug Delivery with Vibrating Mesh Nebulizers During Mechanical Ventilation.

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM Journal of Aerosol Medicine and Pulmonary Drug Delivery Pub Date : 2024-06-01 Epub Date: 2024-04-01 DOI:10.1089/jamp.2023.0026
Hui-Ling Lin, James B Fink, Jie Li
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Abstract

Background: Some experts recommend specific ventilator settings during nebulization for mechanically ventilated patients, such as inspiratory pause, high inspiratory to expiratory ratio, and so on. However, it is unclear whether those settings improve aerosol delivery. Thus, we aimed to evaluate the impact of ventilator settings on aerosol delivery during mechanical ventilation (MV). Methods: Salbutamol (5.0 mg/2.5 mL) was nebulized by a vibrating mesh nebulizer (VMN) in an adult MV model. VMN was placed at the inlet of humidifier and 15 cm away from the Y-piece of the inspiratory limb. Eight scenarios with different ventilator settings were compared with endotracheal tube (ETT) connecting 15 cm from the Y-piece, including tidal volumes of 6-8 mL/kg, respiratory rates of 12-20 breaths/min, inspiratory time of 1.0-2.5 seconds, inspiratory pause of 0-0.3 seconds, and bias flow of 3.5 L/min. In-line suction catheter was utilized in two scenarios. Delivered drug distal to the ETT was collected by a filter, and drug was assayed by an ultraviolet spectrophotometry (276 nm). Results: Compared to the use of inspiratory pause, the inhaled dose without inspiratory pause was either higher or similar across all ventilation settings. Inhaled dose was negatively correlated with inspiratory flow with VMN placed at 15 cm away from the Y-piece (rs = -0.68, p < 0.001) and at the inlet of humidifier (rs = -0.83, p < 0.001). The utilization of in-line suction catheter reduced inhaled dose, regardless of the ventilator settings and nebulizer placements. Conclusions: When VMN was placed at the inlet of humidifier, directly connecting the Y-piece to ETT without a suction catheter improved aerosol delivery. In this configuration, the inhaled dose increased as the inspiratory flow decreased, inspiratory pause had either no or a negative impact on aerosol delivery. The inhaled dose was greater with VMN placed at the inlet of humidifier than 15 cm away the Y-piece.

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机械通气时吸气流量、吸气暂停和抽吸导管对振动网式雾化器气溶胶给药的影响
背景:一些专家建议机械通气患者在雾化吸入时使用特定的呼吸机设置,如吸气暂停、高吸呼比等。然而,目前还不清楚这些设置是否能改善气溶胶输送。因此,我们旨在评估机械通气(MV)期间呼吸机设置对气溶胶输送的影响。方法在成人 MV 模型中使用振动网状雾化器 (VMN) 雾化吸入沙丁胺醇(5.0 毫克/2.5 毫升)。VMN 放置在加湿器入口处,距离吸气肢 Y 型片 15 厘米。将气管导管(ETT)连接到距 Y 型肢体 15 厘米处,比较了不同呼吸机设置下的八种情况,包括潮气量 6-8 毫升/千克、呼吸频率 12-20 次/分钟、吸气时间 1.0-2.5 秒、吸气暂停 0-0.3 秒和偏压流量 3.5 升/分钟。在两种情况下使用在线抽吸导管。通过过滤器收集 ETT 远端输送的药物,并通过紫外分光光度计(276 纳米)对药物进行检测。结果:与使用吸气暂停相比,在所有通气设置下,不使用吸气暂停的吸入剂量要么更高,要么相似。当 VMN 放置在距离 Y 管 15 厘米处时,吸入剂量与吸气流量呈负相关(rs = -0.68,p rs = -0.83,p 结论:当 VMN 放置在入口处时,吸入剂量与吸气流量呈负相关(rs = -0.68,p rs = -0.83,p 结论):当 VMN 放置在加湿器入口处时,直接将 Y 型件连接到 ETT 而不使用吸引导管可改善气溶胶输送。在这种配置下,吸入剂量随着吸气流量的减少而增加,吸气暂停对气溶胶输送没有影响或有负面影响。将 VMN 放在加湿器入口处的吸入剂量大于 Y 型管 15 厘米处的吸入剂量。
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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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