Associations of Serum Irisin and Fibroblast Growth Factor-21 Levels With Bone Mineral Characteristics in Eumenorrheic Adolescent Athletes With Different Training Activity Patterns.
Jaak Jürimäe, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Katre Maasalu, Vallo Tillmann
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引用次数: 0
Abstract
Purpose: To describe serum irisin and fibroblast growth factor-21 (FGF-21) concentrations in healthy female adolescents with different training activity patterns and their associations with bone mineral properties and metabolic markers.
Methods: A total of 62 adolescent girls aged 14-18 years were recruited: 22 rhythmic gymnasts, 20 swimmers, and 20 untrained controls. Bone mineral characteristics by dual-energy X-ray absorptiometry, daily energy intake by dietary recall, serum irisin, FGF-21, undercarboxylated osteocalcin, and C-terminal telopeptide of type I collagen were measured in all girls.
Results: Whole body and lumbar spine areal bone mineral density and lumbar spine bone mineral content were higher in the rhythmic gymnasts group compared with swimmers and untrained controls groups (P < .05). Serum irisin, FGF-21, undercarboxylated osteocalcin, and C-terminal telopeptide of type I collagen levels were not significantly different between the groups. In the rhythmic gymnasts group, serum FGF-21 concentration was positively correlated with lumbar spine areal bone mineral density independently of confounding factors (r = .51; P = .027).
Conclusions: Serum irisin and FGF-21 levels were not different between adolescent eumenorrheic girls with different training activity patterns. FGF-21 was positively associated with lumbar spine areal bone mineral density, which predominantly consists of trabecular bone in adolescent rhythmic gymnasts.
目的：描述不同训练活动模式的健康女性青少年血清鸢尾素和成纤维细胞生长因子-21（FGF-21）的浓度及其与骨矿物质特性和代谢指标的关系：共招募了 62 名 14-18 岁的少女：22 名韵律操运动员、20 名游泳运动员和 20 名未接受过训练的对照组。通过双能量 X 射线吸收测量法测量了所有女孩的骨矿物质特征，通过饮食回忆法测量了每日能量摄入量，还测量了血清鸢尾素、成纤维细胞生长因子-21、羧化骨钙素和 I 型胶原蛋白 C 端端肽：结果：与游泳运动员组和未经训练的对照组相比，韵律操运动员组的全身和腰椎骨矿物质密度以及腰椎骨矿物质含量更高（P < .05）。血清鸢尾素、成纤维细胞生长因子-21、欠羧化骨钙素和 I 型胶原蛋白 C 端端肽水平在各组间无显著差异。在韵律操运动员组中，血清 FGF-21 浓度与腰椎平均骨矿密度呈正相关，不受干扰因素的影响（r = .51; P = .027）：结论：血清鸢尾素和 FGF-21 水平在不同训练活动模式的青春期易流产女孩之间没有差异。FGF-21与腰椎骨矿物质密度呈正相关，青少年韵律操运动员的腰椎骨矿物质密度主要由小梁骨构成。
期刊介绍：
Pediatric Exercise Science is a journal committed to enriching the scientific knowledge of exercise during childhood and adolescence. To this end it publishes information that contributes to an understanding of (a) the unique aspects of the physiologic, physical, biochemical, and psychologic responses of children to exercise, (b) the role of exercise in the treatment of pediatric chronic diseases, (c) the importance of physical activity in the prevention of illness and preservation of wellness, and (d) the means by which participation in sports may be made safer and more enjoyable for children and youth. Consideration will be given for publication of work by various methodologies consistent with the scientific approach.
Besides original research, the journal includes review articles, abstracts from other journals, book reviews, and editorial comments. Pediatric Exercise Science encourages the expression of conflicting opinions regarding children and exercise by providing a forum for alternative viewpoints. At the same time it serves as a means of accumulating a base of research information that will allow application of experimental data to clinical practice. The scientific disciplines contributing to this body of knowledge are diverse. Therefore it is the purpose of this journal to provide a common focus for disseminating advances in the science of exercise during childhood. In doing so, the journal allows the opportunity for cross-fertilization of ideas between disciplines that will potentiate the growth of knowledge in this field. Pediatric Exercise Science seeks to stimulate new ideas regarding exercise in children and to increase the awareness of scientists, health care providers, and physical educators of the importance of exercise during childhood.
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