Intense prostate-specific membrane antigen receptor expression in coronary artery pypass graft scar tissue: A potential molecular imaging pitfall.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica open Pub Date : 2024-03-28 eCollection Date: 2024-02-01 DOI:10.1177/20584601241240318
Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Nabeela Al-Hajaj, Aysar Khalaf, Samer Salah
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Abstract

68Gallium-PSMA positron emission tomography/computer tomography has been utilized recently for the diagnosis and staging of prostate cancer. PSMA is a transmembrane protein that is expressed not only in the prostate gland but also in other tissues. While some pitfalls have been addressed, there are still uncertainties. Herein, we report a 79-year-old male with prostate cancer who underwent a PSMA scan after coronary artery bypass graft surgery, revealing disease progression and PSMA-avid foci at the surgical stitch sites. This report discusses the immunohistochemical and molecular imaging mechanisms underlying PSMA expression in surgical scar tissues, providing critical insights for optimizing radiologic reporting in such situations.

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冠状动脉旁路移植瘢痕组织中前列腺特异性膜抗原受体的强烈表达:潜在的分子成像陷阱
68Gallium-PSMA 正电子发射断层扫描/计算机断层扫描最近被用于前列腺癌的诊断和分期。PSMA 是一种跨膜蛋白,不仅在前列腺中表达,在其他组织中也有表达。虽然已经解决了一些隐患,但仍存在不确定性。本文报告了一名 79 岁的男性前列腺癌患者,他在接受冠状动脉旁路移植手术后接受了 PSMA 扫描,结果显示疾病进展和手术缝合处的 PSMA-avid 病灶。本报告讨论了手术瘢痕组织中 PSMA 表达的免疫组化和分子成像机制,为优化此类情况下的放射学报告提供了重要见解。
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