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Hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in patients with probable Alzheimer's disease correlates with cerebral cortical atrophy.
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-04 eCollection Date: 2025-02-01 DOI: 10.1177/20584601251317629
Hiroshi Ishizaka, Akiko Sekine, Minoru Naka, Saeki Nakano, Hiroyuki Nagase, Yoshito Tsushima

Background: The left piriform cortex and amygdala (PC&A) tend to be slightly hyperintense relative to the right PC&A on T2-weighted fluid-attenuated inversion recovery (T2W-FLAIR) images in patients with probable Alzheimer's disease (pAD). This likely represents the antecedent and thus advanced degeneration of the left PC&A.

Purpose: To investigate the relationship between left PC&A hyperintensities and cerebral cortical atrophy on magnetic resonance (MR) voxel-based morphometry in patients with pAD and discuss how this finding could relate to AD progression.

Material and methods: Patients with pAD (n = 47; age range = 68-93 years, mean = 80.8 ± 6.7 years; 14 men and 33 women) who underwent T2W-FLAIR imaging and MR morphometric study using a voxel-based specific regional analysis system for AD (VSRAD) were retrospectively examined. To measure signal intensity ratios of the left to right PC&A (L-PC&A/R-PC&A), regions of interest (ROIs) were set on the transaxial images in which both PC&As were most broadly depicted; the ROIs were defined as large as possible. Correlations between the L-PC&A/R-PC&A and medial temporal lobe cortical atrophy (MTLCA) as well as whole cerebral cortical atrophy (WCCA) on VSRAD were determined. Correlation between the L-PC&A/R-PC&A and age was also determined.

Results: The L-PC&A/R-PC&A correlated with both MTLCA (r = 0.375, p = .010, 95% confidence interval [CI] = 0.095-0.600) and WCCA (r = 0.576, p < .001, 95% CI = 0.343-0.742). The L-PC&A/R-PC&A did not correlate with age (r = 0.013, p = .932, 95% CI = -0.282-0.305).

Conclusion: Left-sided dominance of PC&A degeneration appeared to accelerate with the progression of AD stages.

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引用次数: 0
Cardiac metastasis of a soft tissue sarcoma: Case report and review of literature. 软组织肉瘤心脏转移一例报告及文献复习。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.1177/20584601241313111
Ayoub Chetoui, Oula Alouazen, Lamya Yazghi Martahe, Asmae Oulad Amar, Siham Alaoui Rachidi

Cardiac metastases are the most frequent cardiac tumors. They can cause dysrhythmia, myocardial dysfunction, pericardial effusion, and heart failure. In decreasing order, the major primary malignancies associated with cardiac metastases are pleural mesothelioma, lung adenocarcinoma, undifferentiated carcinomas, lung squamous cell carcinoma, and breast carcinoma. Cardiac metastasis of sarcomas is uncommon, and only a limited number of cases have been found in literature. We report the case of an incidentally discovered cardiac metastasis when assessing the extension of a thigh mass in a 45-year-old man.

心脏转移瘤是最常见的心脏肿瘤。它们可引起心律失常、心肌功能障碍、心包积液和心力衰竭。与心脏转移相关的主要原发恶性肿瘤依次为胸膜间皮瘤、肺腺癌、未分化癌、肺鳞状细胞癌和乳腺癌。肉瘤的心脏转移并不常见,文献中只发现少数病例。我们报告的情况下,偶然发现心脏转移时,评估大腿肿块的延伸在一个45岁的男子。
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引用次数: 0
Endovascular stent graft treatment for stenosis in isolated infrarenal abdominal aortic dissection: A case report. 血管内支架治疗孤立性肾下腹主动脉夹层狭窄1例。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-16 eCollection Date: 2024-12-01 DOI: 10.1177/20584601241309006
Kengo Ohta, Risa Arahata, Junji Horiba, Hitomi Kaneko, Kurando Kondo

We report a case of complicated isolated infrarenal abdominal aortic dissection (IAAD) that was treated with stent graft. A 79-year-old man presented with acute bilateral lower limb pain. A contrast-enhanced CT performed 2 h later revealed sever stenosis of infrarenal abdominal aorta due to IAAD. Angiography identified a primary tear just below the upper end of the IAAD. A smaller stent graft was placed distally to avoid stent graft-induced new entry, and a large stent graft was placed proximally to cover the primary entry. The stenosis improved immediately after the procedure, and pain relief was achieved. Stent graft placement for entry closure appeared to be an effective for IAAD.

我们报告一例复杂的孤立性肾下腹主动脉夹层(IAAD)用支架移植治疗。一名79岁男性,表现为急性双侧下肢疼痛。2小时后行CT增强检查,发现IAAD所致严重的腹下主动脉狭窄。血管造影发现在IAAD上端下方有原发性撕裂。在远端放置一个较小的支架以避免支架诱导的新进入,在近端放置一个较大的支架以覆盖原进入。手术后狭窄立即改善,疼痛得到缓解。对于IAAD来说,放置支架关闭入口似乎是一种有效的方法。
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引用次数: 0
Intense fibroblast activation protein inhibitor localization around the site of embolized gastroduodenal artery in a patient with metachronous pancreatic adenocarcinoma: A potential pitfall in positron imaging. 异时性胰腺腺癌患者胃十二指肠动脉栓塞部位周围强烈的成纤维细胞活化蛋白抑制剂定位:正电子成像的一个潜在缺陷。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-12-09 eCollection Date: 2024-12-01 DOI: 10.1177/20584601241307350
Ahmed Saad Abdlkadir, Hasan Alalawi, Akram Al-Ibraheem

68Gallium-Fibroblast activation protein inhibitor (68Ga-FAPI) positron emission tomography/computed tomography (PET/CT) is increasingly used for evaluating various epithelial neoplasms. Despite addressing some pitfalls, many remain unacknowledged. This report details a 77-year-old man with suspected pancreatic malignancy who underwent a 68Ga-FAPI PET/CT scan post-gastroduodenal coil embolization for upper gastrointestinal bleeding. The scan revealed intense 68Ga-FAPI uptake in the pancreatic body and tail malignancy and around the embolized gastroduodenal artery, indicating a healing process. This highlights the importance of understanding FAPI expression in recent surgical sites for accurate radiologic interpretation.

镓成纤维细胞活化蛋白抑制剂(68Ga-FAPI)正电子发射断层扫描/计算机断层扫描(PET/CT)越来越多地用于评估各种上皮肿瘤。尽管解决了一些问题,但许多问题仍未得到承认。本报告详细介绍了一位77岁的男性疑似胰腺恶性肿瘤,他在胃十二指肠线圈栓塞治疗上消化道出血后接受了68Ga-FAPI PET/CT扫描。扫描显示胰腺体和尾部恶性肿瘤以及栓塞的胃十二指肠动脉周围有强烈的68Ga-FAPI摄取,表明愈合过程。这突出了了解FAPI在近期手术部位表达的重要性,以获得准确的放射学解释。
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引用次数: 0
Automatic segmentation of extensor carpi ulnaris tendon and detection of tendinosis with convolutional neural networks. 尺侧腕伸肌腱的自动分割及卷积神经网络检测。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-11-30 eCollection Date: 2024-11-01 DOI: 10.1177/20584601241297530
Mathias Hämäläinen, Markus Sormaala, Tuomas Kaseva, Eero Salli, Sauli Savolainen, Marko Kangasniemi

Background: Extensor Carpi Ulnaris (ECU) tendinosis, a frequent cause of chronic wrist pain, requires prompt diagnosis to prevent disability. This study demonstrates the use of convolutional neural networks (CNNs) for automated detection and segmentation of the ECU tendon and tendinosis in 2D axial wrist MRI.

Purpose: To develop a CNN for the automated detection of ECU tendon and automatic delineation of tendinosis in 2D wrist MRI. The study serves as a proof-of-concept, demonstrating the feasibility of automating the segmentation of musculoskeletal structures in wrist MRI and offering an efficient solution for detecting tendinosis.

Material and methods: In a retrospective analysis of 1081 patients undergoing wrist MRI imaging, 46 patients exhibited tendinosis. Two deep learning-based methods for segmenting the ECU tendon and T2 hyperintense lesions indicative of tendinosis from 2D axial wrist MRI series were developed and compared in this study. Both methods were trained and evaluated over all 46 patients using Dice score as the main evaluation metric.

Results: The mean ECU tendon segmentation Dice score ranged from 0.61 to 0.64 (± 0.27 to 0.31). Tendinosis detection yielded a Dice score of 0.38 for both the threshold method (±0.19) and the CNN (±0.22). A Dice score > 0.50 indicated successful detection, with our methods achieving a detection rate of 72-76%.

Conclusion: The developed CNN effectively detected and segmented the ECU tendon in 2D MRI series. Tendinosis was detected with comparable accuracy using both signal intensity thresholding and the trained CNN method.

背景:尺侧腕伸肌(ECU)肌腱病是慢性腕关节疼痛的常见原因,需要及时诊断以预防残疾。本研究展示了卷积神经网络(cnn)在二维轴向手腕MRI中用于ECU肌腱和肌腱病的自动检测和分割。目的:研制一种在二维腕关节MRI中用于ECU肌腱自动检测和肌腱病自动圈定的CNN。该研究作为概念验证,证明了在手腕MRI中自动分割肌肉骨骼结构的可行性,并为检测肌腱病提供了有效的解决方案。材料和方法:回顾性分析1081例接受腕关节MRI成像的患者,其中46例表现为肌腱病。本研究开发并比较了两种基于深度学习的方法,用于分割ECU肌腱和2D轴向手腕MRI序列中指示肌腱病的T2高强度病变。以Dice评分作为主要评价指标,对所有46例患者进行两种方法的训练和评价。结果:ECU肌腱分割Dice评分平均值为0.61 ~ 0.64(±0.27 ~ 0.31)。阈值法(±0.19)和CNN(±0.22)的肌腱病检测的Dice评分均为0.38。Dice得分为bb0 0.50表示检测成功,我们的方法实现了72-76%的检测率。结论:发展的CNN在二维MRI序列中能有效地检测和分割ECU肌腱。使用信号强度阈值法和训练后的CNN方法以相当的准确性检测肌腱病。
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引用次数: 0
Differential diagnosis between low-risk and high-risk thymoma: Comparison of diagnostic performance of radiologists with and without deep learning model. 低风险和高风险胸腺瘤的鉴别诊断:使用深度学习模型和不使用深度学习模型的放射科医生诊断效果比较。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-04 eCollection Date: 2024-10-01 DOI: 10.1177/20584601241288509
Yuriko Yoshida, Masahiro Yanagawa, Yukihisa Sato, Tomo Miyata, Atsushi Kawata, Akinori Hata, Noriyuki Tomiyama

Background: There are few CT-based deep learning (DL) studies on thymoma according to the World Health Organization classification.

Purpose: To develop a CT-based DL model to distinguish between low-risk and high-risk thymoma and to compare the diagnostic performance of radiologists with and without the DL model.

Material and methods: 159 patients with 160 thymomas were included. A fine-tuning VGG16 network model with Adam optimizer was used, followed by k-fold cross validation. The dataset consisted of three axial slices, including the maximum tumor size from the CT volume data. The data were augmented 50 times by rotation, zoom, shear, and horizontal/vertical flip. Three independent networks for the CT dataset were considered, and the result was determined by voting. Three radiologists independently diagnosed thymomas with and without the model. The area under the curve (AUC) of the diagnostic performance was compared using receiver operating characteristic analysis.

Results: Accuracy of the DL model was 71.3%. Diagnostic performance of the radiologists was as follows: AUC and accuracy without the DL model, 0.61-0.68 and 61.9%-69.3%; and with the DL model, 0.66-0.69 and 68.1%-70.0%, respectively. AUC of the diagnostic performance showed no significant differences between radiologists with and without the DL model. The DL model tended to increase the diagnostic accuracy, but AUC was not significantly improved.

Conclusion: Diagnostic performance of the DL was comparable to that of radiologists. The DL model assistance tended to increase diagnostic accuracy.

背景:目的:开发一种基于 CT 的深度学习(DL)模型,用于区分低风险和高风险胸腺瘤,并比较放射科医生使用和不使用 DL 模型的诊断性能。使用亚当优化器对 VGG16 网络模型进行微调,然后进行 k 倍交叉验证。数据集由三个轴切片组成,包括 CT 容量数据中肿瘤的最大尺寸。数据通过旋转、缩放、剪切和水平/垂直翻转增强了 50 倍。CT 数据集有三个独立的网络,结果由投票决定。三名放射科医生分别使用和不使用该模型独立诊断胸腺瘤。使用接收器操作特征分析比较了诊断性能的曲线下面积(AUC):结果:DL模型的准确率为71.3%。放射科医生的诊断结果如下:不使用 DL 模型的 AUC 和准确率分别为 0.61-0.68 和 61.9%-69.3%;使用 DL 模型的 AUC 和准确率分别为 0.66-0.69 和 68.1%-70.0%。使用和未使用 DL 模型的放射科医生的诊断性能 AUC 没有明显差异。DL模型倾向于提高诊断准确率,但AUC并没有明显改善:结论:DL的诊断性能与放射科医生的诊断性能相当。结论:DL 的诊断性能与放射科医生的诊断性能相当。
{"title":"Differential diagnosis between low-risk and high-risk thymoma: Comparison of diagnostic performance of radiologists with and without deep learning model.","authors":"Yuriko Yoshida, Masahiro Yanagawa, Yukihisa Sato, Tomo Miyata, Atsushi Kawata, Akinori Hata, Noriyuki Tomiyama","doi":"10.1177/20584601241288509","DOIUrl":"https://doi.org/10.1177/20584601241288509","url":null,"abstract":"<p><strong>Background: </strong>There are few CT-based deep learning (DL) studies on thymoma according to the World Health Organization classification.</p><p><strong>Purpose: </strong>To develop a CT-based DL model to distinguish between low-risk and high-risk thymoma and to compare the diagnostic performance of radiologists with and without the DL model.</p><p><strong>Material and methods: </strong>159 patients with 160 thymomas were included. A fine-tuning VGG16 network model with Adam optimizer was used, followed by k-fold cross validation. The dataset consisted of three axial slices, including the maximum tumor size from the CT volume data. The data were augmented 50 times by rotation, zoom, shear, and horizontal/vertical flip. Three independent networks for the CT dataset were considered, and the result was determined by voting. Three radiologists independently diagnosed thymomas with and without the model. The area under the curve (AUC) of the diagnostic performance was compared using receiver operating characteristic analysis.</p><p><strong>Results: </strong>Accuracy of the DL model was 71.3%. Diagnostic performance of the radiologists was as follows: AUC and accuracy without the DL model, 0.61-0.68 and 61.9%-69.3%; and with the DL model, 0.66-0.69 and 68.1%-70.0%, respectively. AUC of the diagnostic performance showed no significant differences between radiologists with and without the DL model. The DL model tended to increase the diagnostic accuracy, but AUC was not significantly improved.</p><p><strong>Conclusion: </strong>Diagnostic performance of the DL was comparable to that of radiologists. The DL model assistance tended to increase diagnostic accuracy.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"13 10","pages":"20584601241288509"},"PeriodicalIF":0.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cranial nerves bridging the middle ear and cerebellum causing cerebellar peduncle abscess: A case report. 连接中耳和小脑的颅神经导致小脑脚脓肿:病例报告。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 DOI: 10.1177/20584601241279337
Prabin Shrestha, Mani Ratnesh S Sandhu, Katherine J Jensen, Satoka Shidoh, Satoshi Yamaguchi

Cerebellar abscess is a reported complication of chronic suppurative otitis media (CSOM) and is life threatening at times. It usually develops by direct spread of CSOM through the bony erosion in the petrous bone or by thrombophlebitis of the sigmoid sinus. However, an alternative pathway of infection transmission from the petrous bone to the cerebellum through the anatomical bridge of the cranial nerves has possibly not been described before. A 63-year-old female patient with CSOM and cholesteatoma developed ataxia and right facial palsy. Computed tomography (CT) showed bone erosion of the right petrous bone suggesting middle ear infection. Post-contrast MRI revealed an enhancement of swollen 7th/8th nerve complex, suggesting neuritis, and cholesteatoma in the right petrous bone. It also showed ring enhancing lesion in the cerebellar peduncle of the same side suggesting brain abscess. Surgical intervention was performed emergently and pus aspirated. She also underwent mastoidectomy and removal of cholesteatoma later by the otolaryngology team and finally got better. This case illustrates that CSOM can cause cerebellar abscess by spreading infection via anatomical bridge of the cranial nerves without direct invasion from the temporal bone or thrombophlebitis of sinus.

据报道,小脑脓肿是慢性化脓性中耳炎(CSOM)的一种并发症,有时会危及生命。小脑脓肿通常是由慢性化脓性中耳炎通过盆骨的骨质侵蚀或乙状窦的血栓性静脉炎直接传播引起的。然而,通过颅神经的解剖桥将感染从隐骨传播到小脑的另一种途径以前可能从未被描述过。一名患有 CSOM 和胆脂瘤的 63 岁女性患者出现共济失调和右侧面瘫。计算机断层扫描(CT)显示右侧耻骨骨质侵蚀,提示中耳感染。对比后磁共振成像显示,肿胀的第 7/8 神经复合物增强,提示神经炎,右侧岩骨有胆脂瘤。磁共振成像还显示同侧小脑脚有环形强化病变,提示脑脓肿。紧急进行了手术治疗,并抽出了脓液。随后,耳鼻喉科团队还为她进行了乳突切除术和胆脂瘤切除术,最终她的病情有所好转。本病例说明,CSOM 可通过颅神经的解剖桥传播感染而导致小脑脓肿,而不会直接从颞骨或鼻窦血栓性静脉炎侵入。
{"title":"Cranial nerves bridging the middle ear and cerebellum causing cerebellar peduncle abscess: A case report.","authors":"Prabin Shrestha, Mani Ratnesh S Sandhu, Katherine J Jensen, Satoka Shidoh, Satoshi Yamaguchi","doi":"10.1177/20584601241279337","DOIUrl":"10.1177/20584601241279337","url":null,"abstract":"<p><p>Cerebellar abscess is a reported complication of chronic suppurative otitis media (CSOM) and is life threatening at times. It usually develops by direct spread of CSOM through the bony erosion in the petrous bone or by thrombophlebitis of the sigmoid sinus. However, an alternative pathway of infection transmission from the petrous bone to the cerebellum through the anatomical bridge of the cranial nerves has possibly not been described before. A 63-year-old female patient with CSOM and cholesteatoma developed ataxia and right facial palsy. Computed tomography (CT) showed bone erosion of the right petrous bone suggesting middle ear infection. Post-contrast MRI revealed an enhancement of swollen 7<sup>th</sup>/8<sup>th</sup> nerve complex, suggesting neuritis, and cholesteatoma in the right petrous bone. It also showed ring enhancing lesion in the cerebellar peduncle of the same side suggesting brain abscess. Surgical intervention was performed emergently and pus aspirated. She also underwent mastoidectomy and removal of cholesteatoma later by the otolaryngology team and finally got better. This case illustrates that CSOM can cause cerebellar abscess by spreading infection via anatomical bridge of the cranial nerves without direct invasion from the temporal bone or thrombophlebitis of sinus.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"13 10","pages":"20584601241279337"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computed tomography patterns and clinical outcomes of radiation pneumonitis in non-small-cell lung cancer patients. 非小细胞肺癌患者放射性肺炎的计算机断层扫描模式和临床结果。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-01 DOI: 10.1177/20584601241288502
Ji Hoon Choi, Hee Kang, Ji Su Lim, Ki-Nam Lee

Background: Radiation pneumonitis (RP) is not an uncommon complication in lung cancer patients undergoing radiation therapy (RT) and symptomatic RP can affect their quality of life.

Purpose: To investigate the CT findings of RP in non-small cell lung cancer (NSCLC) patients and their relationship with clinical outcomes.

Materials and methods: We reviewed data from 240 NSCLC patients who underwent RT between 2014 and 2022. CT findings of RP were evaluated for parenchymal abnormalities and distribution, which were then classified into three patterns: localized pneumonia (LP), cryptogenic organizing pneumonia (COP), and acute interstitial pneumonia (AIP). Clinical outcomes of RP were evaluated based on Common Terminology Criteria for Adverse Events (CTCAE) grade.

Results: Of the 153 patients, 135 developed RP. The most common pattern was LP (n = 78), followed by COP (n = 30) and AIP (n = 25). Among the three CT patterns, CTCAE grade and days between the start of RT and the onset of RP (RT-RP days) were statistically significantly different (p < 0.05). The patients with AIP patterns exhibited higher CTCAE grade, and fewer RT-RP days compared to those with non-AIP patterns (p < 0.05). In these patients, lung-to-lung metastasis and underlying interstitial lung abnormality were observed more frequently (p < 0.05). Underlying pulmonary fibrosis, the AIP pattern, and higher CT extent scores were more frequently observed in higher CTCAE grade group (p < 0.001). In multiple regression analysis, age, bilateral distribution, RT-RP days, and CT extent score ≥3 were independent predicting factors for higher CTCAE grade.

Conclusions: RP in NSCLC patients can be classified into LP, COP, and AIP patterns and they exhibit different severities in clinical outcomes.

背景:目的:研究非小细胞肺癌(NSCLC)患者放射性肺炎的 CT 检查结果及其与临床结果的关系:我们回顾了2014年至2022年间接受RT治疗的240名NSCLC患者的数据。对RP的CT结果进行了实质异常和分布评估,然后将其分为三种模式:局部肺炎(LP)、隐源性有组织肺炎(COP)和急性间质性肺炎(AIP)。根据不良事件通用术语标准(CTCAE)的分级对RP的临床结果进行了评估:结果:在 153 名患者中,135 人出现了 RP。最常见的模式是 LP(78 例),其次是 COP(30 例)和 AIP(25 例)。在三种 CT 模式中,CTCAE 分级和 RT 开始至 RP 发病之间的天数(RT-RP 天数)有显著统计学差异(P < 0.05)。与非 AIP 模式的患者相比,AIP 模式患者的 CTCAE 分级更高,RT-RP 天数更少(P < 0.05)。在这些患者中,肺转移和潜在的肺间质异常更常见(P < 0.05)。在CTCAE等级较高的组别中,更常观察到潜在的肺纤维化、AIP模式和较高的CT范围评分(P < 0.001)。在多元回归分析中,年龄、双侧分布、RT-RP天数和CT范围评分≥3是较高CTCAE分级的独立预测因素:结论:NSCLC患者的RP可分为LP、COP和AIP模式,它们在临床结果中表现出不同的严重程度。
{"title":"Computed tomography patterns and clinical outcomes of radiation pneumonitis in non-small-cell lung cancer patients.","authors":"Ji Hoon Choi, Hee Kang, Ji Su Lim, Ki-Nam Lee","doi":"10.1177/20584601241288502","DOIUrl":"https://doi.org/10.1177/20584601241288502","url":null,"abstract":"<p><strong>Background: </strong>Radiation pneumonitis (RP) is not an uncommon complication in lung cancer patients undergoing radiation therapy (RT) and symptomatic RP can affect their quality of life.</p><p><strong>Purpose: </strong>To investigate the CT findings of RP in non-small cell lung cancer (NSCLC) patients and their relationship with clinical outcomes.</p><p><strong>Materials and methods: </strong>We reviewed data from 240 NSCLC patients who underwent RT between 2014 and 2022. CT findings of RP were evaluated for parenchymal abnormalities and distribution, which were then classified into three patterns: localized pneumonia (LP), cryptogenic organizing pneumonia (COP), and acute interstitial pneumonia (AIP). Clinical outcomes of RP were evaluated based on Common Terminology Criteria for Adverse Events (CTCAE) grade.</p><p><strong>Results: </strong>Of the 153 patients, 135 developed RP. The most common pattern was LP (<i>n</i> = 78), followed by COP (<i>n</i> = 30) and AIP (<i>n</i> = 25). Among the three CT patterns, CTCAE grade and days between the start of RT and the onset of RP (RT-RP days) were statistically significantly different (<i>p</i> < 0.05). The patients with AIP patterns exhibited higher CTCAE grade, and fewer RT-RP days compared to those with non-AIP patterns (<i>p</i> < 0.05). In these patients, lung-to-lung metastasis and underlying interstitial lung abnormality were observed more frequently (<i>p</i> < 0.05). Underlying pulmonary fibrosis, the AIP pattern, and higher CT extent scores were more frequently observed in higher CTCAE grade group (<i>p</i> < 0.001). In multiple regression analysis, age, bilateral distribution, RT-RP days, and CT extent score ≥3 were independent predicting factors for higher CTCAE grade.</p><p><strong>Conclusions: </strong>RP in NSCLC patients can be classified into LP, COP, and AIP patterns and they exhibit different severities in clinical outcomes.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"13 10","pages":"20584601241288502"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive trigeminal ganglioneuroma: A case report and review of the literature. 侵袭性三叉神经节瘤:病例报告和文献综述。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-09 eCollection Date: 2024-09-01 DOI: 10.1177/20584601241283780
Rama Krishna Narra, Kavya Are, Parveen Nuzhat

Ganglioneuromas are rare tumors arising from retroperitoneal and posterior mediastinal sympathetic nerves. Intracranial trigeminal nerve ganglioneuromas are even more rare, with only seven cases reported to date. We present a case of a 65-year-old male with a right-sided throbbing headache type and blindness in his right eye. Magnetic resonance imaging revealed an ill-defined mass lesion in the middle-cranial fossa, with a few areas having a reduced apparent diffusion coefficient and multiple microhemorrhages. Piecemeal debulking of the tumor was achieved by performing a right-middle craniotomy via the pterionic and sub-temporal approach. The detected histological features matched those of a ganglioneuroma (maturing type) of the trigeminal nerve.

神经节血管瘤是一种罕见的肿瘤,由腹膜后和纵隔后交感神经引起。颅内三叉神经节瘤更为罕见,迄今仅有七例报道。我们报告了一例 65 岁男性的病例,他患有右侧搏动性头痛,右眼失明。磁共振成像显示,中颅窝有一个界限不清的肿块病变,少数区域的表观弥散系数降低,并有多处微出血。通过翼下和颞下入路进行右侧中开颅手术,对肿瘤进行了碎块剥离。检测到的组织学特征与三叉神经节瘤(成熟型)相符。
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引用次数: 0
A case of primary osteosarcoma in the occipital bone: A relatively common tumor in an uncommon location. 一例枕骨原发性骨肉瘤:不常见部位的一种相对常见的肿瘤。
IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-30 eCollection Date: 2024-09-01 DOI: 10.1177/20584601241279134
Kezhou Xing, Guoli Ren, Shuning Liu, Chuanchen Zhang

Osteosarcomas predominantly manifest in the long bones of the extremities, with rare occurrences in the skull. A case involving of a 53-year-old female who presented to the authors' hospital for examination due to dizziness was incidentally found to have an occipital bone mass, which was initially diagnosed as a benign tumor and did not receive sufficient attention. Two years later, owing to tumor enlargement, the patient underwent further evaluation at the same institution, which revealed evidence of occipital bone destruction. Pathological analysis confirmed the diagnosis of osteosarcoma. The patient underwent surgical resection followed by radiotherapy. Despite its infrequency and uncharacteristic initial presentation, skull osteosarcomas should not be overlooked.

骨肉瘤主要发生在四肢的长骨中,在颅骨中很少见。作者所在医院曾接诊过一例 53 岁女性患者,因头晕到医院检查,偶然发现枕骨肿块,最初诊断为良性肿瘤,未引起足够重视。两年后,由于肿瘤增大,患者在同一家医院接受了进一步评估,结果显示枕骨骨质破坏。病理分析证实了骨肉瘤的诊断。患者接受了手术切除和放射治疗。尽管颅骨骨肉瘤并不常见,而且最初表现也不典型,但不应被忽视。
{"title":"A case of primary osteosarcoma in the occipital bone: A relatively common tumor in an uncommon location.","authors":"Kezhou Xing, Guoli Ren, Shuning Liu, Chuanchen Zhang","doi":"10.1177/20584601241279134","DOIUrl":"10.1177/20584601241279134","url":null,"abstract":"<p><p>Osteosarcomas predominantly manifest in the long bones of the extremities, with rare occurrences in the skull. A case involving of a 53-year-old female who presented to the authors' hospital for examination due to dizziness was incidentally found to have an occipital bone mass, which was initially diagnosed as a benign tumor and did not receive sufficient attention. Two years later, owing to tumor enlargement, the patient underwent further evaluation at the same institution, which revealed evidence of occipital bone destruction. Pathological analysis confirmed the diagnosis of osteosarcoma. The patient underwent surgical resection followed by radiotherapy. Despite its infrequency and uncharacteristic initial presentation, skull osteosarcomas should not be overlooked.</p>","PeriodicalId":72063,"journal":{"name":"Acta radiologica open","volume":"13 9","pages":"20584601241279134"},"PeriodicalIF":0.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acta radiologica open
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