A new mouse-fixation device for IOP measurement in awake mice

IF 1.5 4区心理学 Q4 NEUROSCIENCES Vision Research Pub Date : 2024-04-04 DOI:10.1016/j.visres.2024.108397

Jiaxin Guo , Jialiang Yang , Haotian Huang , Kai Wu , Xiawei Wu , Haolin Wang , Yu He , Fanfeng Bi , Chenyazhuo Hu , Bo Gong , Houbin Zhang

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Abstract

Glaucoma is an irreversible blinding eye disease. The mechanisms underlying glaucoma are complex. Up to now, no successful remedy has been found to completely cure the condition. High intraocular pressure (IOP) is an established risk factor for glaucoma and the only known modifiable factor for glaucoma treatment. Mice have been widely used to study glaucoma pathogenesis. IOP measurement is an important tool for monitoring the potential development of glaucomatous phenotypes in glaucoma mouse models. Currently, there are two methods of IOP measurement in mice: invasive and non-invasive. As the invasive method can cause corneal damage and inflammation, and most of the noninvasive method involves the use of anesthetics. In the course of our research, we designed a mouse fixation device to facilitate non-invasive measurements of mouse IOPs. Using this device, mouse IOPs can be accurately measured in awake mice. This device will help researchers to accurately assess mouse IOP without the use of anesthetics.

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用于测量清醒小鼠眼压的新型小鼠固定装置

青光眼是一种不可逆的致盲性眼病。青光眼的发病机制十分复杂。迄今为止，还没有找到能够彻底治愈这种疾病的成功疗法。高眼压是青光眼的既定风险因素，也是治疗青光眼的唯一已知可调节因素。小鼠已被广泛用于研究青光眼的发病机制。眼压测量是监测青光眼小鼠模型中青光眼表型潜在发展的重要工具。目前，小鼠眼压测量有两种方法：有创和无创。由于侵入式方法会造成角膜损伤和炎症，而大多数非侵入式方法需要使用麻醉剂。在研究过程中，我们设计了一种小鼠固定装置，以方便对小鼠眼压进行无创测量。使用该装置，可以准确测量清醒小鼠的眼压。该装置将帮助研究人员在不使用麻醉剂的情况下准确评估小鼠的眼压。

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来源期刊

Vision Research 医学-神经科学

CiteScore

3.70

自引率

16.70%

发文量

111

审稿时长

66 days

期刊介绍： Vision Research is a journal devoted to the functional aspects of human, vertebrate and invertebrate vision and publishes experimental and observational studies, reviews, and theoretical and computational analyses. Vision Research also publishes clinical studies relevant to normal visual function and basic research relevant to visual dysfunction or its clinical investigation. Functional aspects of vision is interpreted broadly, ranging from molecular and cellular function to perception and behavior. Detailed descriptions are encouraged but enough introductory background should be included for non-specialists. Theoretical and computational papers should give a sense of order to the facts or point to new verifiable observations. Papers dealing with questions in the history of vision science should stress the development of ideas in the field.

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