Estimation of the Levels of UDP Glucuronosyltransferase 2 Activity and some Vitamins (B12, B17, C and D) for Patients with Colon Cancer

Abstract

One of the most prevalent types of cancer in humans and a well-known cause of mortality is colon cancer. This study aimed to measure the serum levels of UDP glucuronosyltransferase vitamins (B12, B17, C and D) in patients with colon cancer and to determine how these levels affect the course of the disease. The participants in the current study include 45 healthy people (mean age = 62.03±12.3 yrs.) who serve as a comparison group and 65 subjects with subjectively diagnosed colon cancer (mean age = 64.03±12.2 yrs.). The serum UDP glucuronosyltransferase 2B17, Vitamin B12, Vitamin D, and Vitamin C levels were among the determined biochemical markers . When colon cancer patients were compared to the control group, UDP glucuronosyltransferase 2B17 levels were significantly higher (P < 0.0001). In comparison to the control group, the serum Vitamin B12, Vitamin D, and Vitamin C levels in colon cancer patients were all considerably lower (P < 0.0001), P < 0.001, and P< 0.05, respectively). In our investigation, a marker for colon cancer was shown to be an increase in blood UDP glucuronosyltransferase 2B17 and a decrease in vitamin B12