Severe Hypophosphatemia After Ferric Carboxymaltose Infusion: A Case Report

N. Arranz-Pasqual, A. Torrent-Rodríguez, M. T. Miana-Mena, E. López-Suñé, N. Corominas-García, I. Blanco, D. Soy-Muner
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Abstract

Ferric carboxymaltose (FCM) allows for rapid and total correction of iron deficiency with a lower risk of hypersensitivity reactions compared to other IV iron preparations. However, FCM is associated with potentially serious adverse events, including hypophosphatemia, following the infusion. The mechanism behind FCM-induced hypophosphatemia is not well understood, but pre-existing risk factors can increase the likelihood of severe and persistent hypophosphatemia. We report a clinical case of a male patient who developed severe hypophosphatemia (1.0 mg/dL) after administration of FCM for the treatment of post-cardiotomy normocytic anemia. He required hospital admission and 16 weeks of phosphorous supplementation.
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输注羧甲基铁后出现严重低磷血症:病例报告
与其他静脉注射铁制剂相比,羧甲基铁(FCM)能快速、彻底地纠正缺铁症状,且发生过敏反应的风险较低。然而,FCM 在输注后可能会出现严重的不良反应,包括低磷血症。FCM诱发低磷血症的机制尚不十分清楚,但已有的风险因素会增加发生严重和持续性低磷血症的可能性。我们报告了一例男性患者的临床病例,他在使用 FCM 治疗心肌梗死术后正常血细胞性贫血后,出现了严重的低磷血症(1.0 mg/dL)。他需要入院接受为期 16 周的磷补充治疗。
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