Assessment of ghrelin and resistin levels in a group of obese men with metabolic syndrome

Abstract

Background: Obesity is a chronic disease associated with numerous complications, including metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Adipose tissue functions as an endocrine organ, producing hormones that play a crucial role in regulating metabolic homeostasis, such as ghrelin and resistin. Objective: The aim of this study was to compare the levels of resistin and ghrelin in obese men with metabolic syndrome and age-matched men without metabolic syndrome. Methods: Anthropometric measurements and biochemical assays were conducted to assess glycemia, resistin levels, insulin levels, and ghrelin levels. Results: The study comprised 58 obese men with metabolic syndrome and 53 age-matched control group men. In obese individuals, there was a significant increase in insulin and resistin levels, while ghrelin levels were notably decreased compared to the control group. Additionally, a positive correlation was observed between resistin levels and parameters such as BMI, waist circumference, and insulin levels. Conclusion: The findings from this study suggest that both resistin and ghrelin may serve as potential biomarkers for identifying metabolic syndrome in obese men.