Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0027
Rachel Siqueira de Queiroz Simões
More than 200 HPV genotypes and several HPV types associated with particular diseases as oral lesions (Hecks disease, oropharyngeal carcinoma, laryngeal papillomas), anogenital warts (Bowenoid papulosis, Buschike‒Lowenstein tumor), Epidermodysplasia verruciformis (plane warts, Pityriasis‒ like plaques, squamous cell carcinomas of sun‒exposed skin) have been described. Several advances in the genomics era and the development of new technological tools for next-generation sequencing have been showed that approximately 98% of RNAs are not translated into proteins. This study aims to succinctly describe long non-coding RNAs (lncRNAs) and their correlation with the hallmark of cancers since they comprise a class of RNAs that do not code for proteins. Oncogenic mutations occur with higher prevalence in non-coding regions, and the correlation of lncRNAs is extremely important for better understanding the biology of cancer cells as well as elucidating the molecular mechanisms underlying cancer. Thus, these may be promising tumor biomarkers and potential therapeutic targets exemplified in hepatocellular carcinoma, cervical and colorectal cancer induced by oncogenic viruses. Future studies are need to delve deeper into the cellular signaling pathways involved in biological processes. This theme addresses innovative issues on the ONU 2030 agenda from the perspective of global one health.
{"title":"Next generation of mRNA and lncRNAs based-vaccines platforms: Highlighted for HPV in head and neck squamous cell carcinoma, cervical and colorectal cancers and oncogenic viruses HBV/HCV in hepatocellular carcinoma","authors":"Rachel Siqueira de Queiroz Simões","doi":"10.53771/ijbpsa.2024.7.1.0027","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0027","url":null,"abstract":"More than 200 HPV genotypes and several HPV types associated with particular diseases as oral lesions (Hecks disease, oropharyngeal carcinoma, laryngeal papillomas), anogenital warts (Bowenoid papulosis, Buschike‒Lowenstein tumor), Epidermodysplasia verruciformis (plane warts, Pityriasis‒ like plaques, squamous cell carcinomas of sun‒exposed skin) have been described. Several advances in the genomics era and the development of new technological tools for next-generation sequencing have been showed that approximately 98% of RNAs are not translated into proteins. This study aims to succinctly describe long non-coding RNAs (lncRNAs) and their correlation with the hallmark of cancers since they comprise a class of RNAs that do not code for proteins. Oncogenic mutations occur with higher prevalence in non-coding regions, and the correlation of lncRNAs is extremely important for better understanding the biology of cancer cells as well as elucidating the molecular mechanisms underlying cancer. Thus, these may be promising tumor biomarkers and potential therapeutic targets exemplified in hepatocellular carcinoma, cervical and colorectal cancer induced by oncogenic viruses. Future studies are need to delve deeper into the cellular signaling pathways involved in biological processes. This theme addresses innovative issues on the ONU 2030 agenda from the perspective of global one health.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0032
Sodiq Odetunde Babatunde
This theoretical review explores the critical role of business model innovation in the healthcare industry, focusing on entrepreneurial strategies within the medical sector. With the constant evolution of healthcare needs, technologies, and regulations, traditional models are becoming increasingly insufficient to meet the demands of patients, providers, and other stakeholders. Business model innovation offers a pathway for organizations to adapt, thrive, and deliver value in this dynamic landscape. Drawing upon existing literature and case studies, this paper examines the fundamental concepts of business model innovation and its application within healthcare. It explores various entrepreneurial strategies, including opportunity identification, collaboration, technology integration, and patient-centered approaches, highlighting their impact on reshaping the healthcare ecosystem. Furthermore, the theoretical framework delineates key components of successful business model innovation, such as value proposition design, revenue model development, infrastructure optimization, and customer segmentation. Through analysis of real-world examples and challenges, this review elucidates the opportunities and barriers associated with business model innovation in healthcare. It underscores the importance of fostering a culture of innovation, promoting interdisciplinary collaboration, and addressing regulatory complexities to drive sustainable change. Additionally, it outlines future directions for research, implications for healthcare practitioners and policymakers, and the imperative for continuous adaptation and improvement. Ultimately, this review contributes to a deeper understanding of how entrepreneurial strategies can catalyze business model innovation in healthcare, paving the way for enhanced quality, accessibility, and affordability of healthcare services in the digital age.
{"title":"Business model innovation in healthcare: A theoretical review of entrepreneurial strategies in the medical sector","authors":"Sodiq Odetunde Babatunde","doi":"10.53771/ijbpsa.2024.7.1.0032","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0032","url":null,"abstract":"This theoretical review explores the critical role of business model innovation in the healthcare industry, focusing on entrepreneurial strategies within the medical sector. With the constant evolution of healthcare needs, technologies, and regulations, traditional models are becoming increasingly insufficient to meet the demands of patients, providers, and other stakeholders. Business model innovation offers a pathway for organizations to adapt, thrive, and deliver value in this dynamic landscape. Drawing upon existing literature and case studies, this paper examines the fundamental concepts of business model innovation and its application within healthcare. It explores various entrepreneurial strategies, including opportunity identification, collaboration, technology integration, and patient-centered approaches, highlighting their impact on reshaping the healthcare ecosystem. Furthermore, the theoretical framework delineates key components of successful business model innovation, such as value proposition design, revenue model development, infrastructure optimization, and customer segmentation. Through analysis of real-world examples and challenges, this review elucidates the opportunities and barriers associated with business model innovation in healthcare. It underscores the importance of fostering a culture of innovation, promoting interdisciplinary collaboration, and addressing regulatory complexities to drive sustainable change. Additionally, it outlines future directions for research, implications for healthcare practitioners and policymakers, and the imperative for continuous adaptation and improvement. Ultimately, this review contributes to a deeper understanding of how entrepreneurial strategies can catalyze business model innovation in healthcare, paving the way for enhanced quality, accessibility, and affordability of healthcare services in the digital age.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"10 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0023
Devika k, Anandalakshmy K N, Ajitha k
Biological rhythms that sustain life exhibit periodic fluctuations in response to environmental changes. In the absence of external inputs, rhythms are maintained by this internal mechanism. Three primary types of rhythms can be distinguished: Circadian, Ultradian, and Infradian. The Tridosha theory, which forms the basis of Ayurveda, has a deep and innate relationship with the concept of biological rhythms. These rhythms are closely associated with an Ayurvedic theory called "Loka Purusha Samya Siddhanta," which postulates that humans are miniature of the cosmos. Understanding the cyclical variations associated with Tridoshas, Agni, and Sharira Bala concerning variables such as age, time of day, seasonal variations, and nutrition is the foundation of Ayurveda. To maintain maximum health, aligning with this natural cycle is imperative. Breaking from it can lead to a variety of mental and physical ailments. Ayurveda recommends activities like dinacharya, ritucharya, sadvritta, and ahara vidhis, as well as seasonal sodhana procedures and acharya rasayana to maintain the rhythmic balance of doshas in a healthy state. This review paper examines biological rhythm from contemporary and Ayurvedic perspectives. It addresses the physiological and pathological characteristics of these rhythms and their significance in the treatment and prevention of disorders associated with them.
{"title":"Harmonizing health through Biorhythms: Ayurvedic insight","authors":"Devika k, Anandalakshmy K N, Ajitha k","doi":"10.53771/ijbpsa.2024.7.1.0023","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0023","url":null,"abstract":"Biological rhythms that sustain life exhibit periodic fluctuations in response to environmental changes. In the absence of external inputs, rhythms are maintained by this internal mechanism. Three primary types of rhythms can be distinguished: Circadian, Ultradian, and Infradian. The Tridosha theory, which forms the basis of Ayurveda, has a deep and innate relationship with the concept of biological rhythms. These rhythms are closely associated with an Ayurvedic theory called \"Loka Purusha Samya Siddhanta,\" which postulates that humans are miniature of the cosmos. Understanding the cyclical variations associated with Tridoshas, Agni, and Sharira Bala concerning variables such as age, time of day, seasonal variations, and nutrition is the foundation of Ayurveda. To maintain maximum health, aligning with this natural cycle is imperative. Breaking from it can lead to a variety of mental and physical ailments. Ayurveda recommends activities like dinacharya, ritucharya, sadvritta, and ahara vidhis, as well as seasonal sodhana procedures and acharya rasayana to maintain the rhythmic balance of doshas in a healthy state. This review paper examines biological rhythm from contemporary and Ayurvedic perspectives. It addresses the physiological and pathological characteristics of these rhythms and their significance in the treatment and prevention of disorders associated with them.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Alligator pepper, a dietary spice used as food flavor enhancer is a common ingredient in pepper soup, a spicy delight in most parts of West Africa and possesses both medicinal and nutritive properties. Despite the well documented benefits of breastfeeding for mothers and infants, there are a variety of medical situations for which breastfeeding is contraindicated. Therefore, lactation suppression might be indicated for the best interest of the mother and/or infant. This study was undertaken to investigate the Lactation suppression effect of aqueous seed extract of Aframomum Melengueta on female albino rats. Methodology: Thirty (30) adult female albino rats weighing 160 to 200 g were used for the study while eighteen (18) albino mice of body weights (b.w.) range of 25 g to 30 g were used for the preliminary acute toxicity test. Male rats were introduced into the female rat cages of groups II-V within 12h at the expected estrous phase for mating and withdrawn thereafter. Groups I, II and III were orally administered distilled water only, while Groups IV and V received oral doses of 5 µg/kg b.w. Carbagoline and 3,000 mg/kg b.w. aqueous seed extract of Aframomum melegueta respectively 24 hours postpartum once daily by oral gavage for 3 days. Results: LD50 determination revealed no death was recorded among the animals up to 5000 mg extract/kg body weight. Study indicates that Aframomum melengueta extract elicited significant reduction of prolactin with corresponding increase in estrogen and progesterone in postpartum animals. Histological sections of the mammary gland show extensive fibrosis and congested ducts lobular units within the tissue stroma of the mammary gland of Aframomum melengueta treated animals. Conclusion: The results confirms a positive lactation suppression effect of aqueous seed extract of Aframomum Melengueta on postpartum lactating female albino rats
{"title":"Lactation suppression effect of aqueous seed extract of Aframomum melengueta on female albino rats","authors":"Uche Emmanuel Olunkwa, Kizito Munachiso Enyereibenyem Iheanacho, Chidi Uzoma Igwe, Linus Ahuwaraeze Nwaogu","doi":"10.53771/ijbpsa.2024.7.1.0024","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0024","url":null,"abstract":"Background and aims: Alligator pepper, a dietary spice used as food flavor enhancer is a common ingredient in pepper soup, a spicy delight in most parts of West Africa and possesses both medicinal and nutritive properties. Despite the well documented benefits of breastfeeding for mothers and infants, there are a variety of medical situations for which breastfeeding is contraindicated. Therefore, lactation suppression might be indicated for the best interest of the mother and/or infant. This study was undertaken to investigate the Lactation suppression effect of aqueous seed extract of Aframomum Melengueta on female albino rats. Methodology: Thirty (30) adult female albino rats weighing 160 to 200 g were used for the study while eighteen (18) albino mice of body weights (b.w.) range of 25 g to 30 g were used for the preliminary acute toxicity test. Male rats were introduced into the female rat cages of groups II-V within 12h at the expected estrous phase for mating and withdrawn thereafter. Groups I, II and III were orally administered distilled water only, while Groups IV and V received oral doses of 5 µg/kg b.w. Carbagoline and 3,000 mg/kg b.w. aqueous seed extract of Aframomum melegueta respectively 24 hours postpartum once daily by oral gavage for 3 days. Results: LD50 determination revealed no death was recorded among the animals up to 5000 mg extract/kg body weight. Study indicates that Aframomum melengueta extract elicited significant reduction of prolactin with corresponding increase in estrogen and progesterone in postpartum animals. Histological sections of the mammary gland show extensive fibrosis and congested ducts lobular units within the tissue stroma of the mammary gland of Aframomum melengueta treated animals. Conclusion: The results confirms a positive lactation suppression effect of aqueous seed extract of Aframomum Melengueta on postpartum lactating female albino rats","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"10 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0026
Rhoda Nwalozie, Mary Egbukele, Chinonye Oluchi Ezenwaka
Soil-transmitted helminths pose significant public health concerns, particularly among school-aged children in resource-constrained settings. This study aimed to investigate the prevalence of soil-transmitted helminths among school-aged pupils in three selected Community Public Primary Schools, Etche Local Government Area, Rivers State, Nigeria. A cross-sectional study was conducted, involving 150 school-aged pupils (1-14 years old) from three Community Primary Schools which included State School 1, State School 2, and Community Primary School, all in Etche. A structured questionnaire was administered to gather information on socio-demographic factors. Stool samples collected from each pupil were examined using the Kato-Katz technique and the STH parasites identified with keys. The overall prevalence of soil-transmitted helminth infection in the three selected schools in this study was 46%. Results obtained from this study according to sex showed that more males (52%) were infected than females (40%). Children between 5-7 years were the most infected in State School 2 and Community Primary School; while children between 12-14 years were the most infected in State School 1. Also, this study revealed that children in State School 2 had the highest soil-transmitted helminths infection (56%); while State School 1 recorded the least infection rate (34%). In this present study, Strongyloides stercoralis was the least prevalent soil-transmitted helminths while Ascaris lumbricoides (36) was the most occurring parasite in this study. There was no association (p>0.05) between age and gender and the prevalence of the parasite infection. A comprehensive control programme should be implemented in the area to curb the spread of infection.
{"title":"Prevalence of soil-transmitted helminths among school-aged pupils in three selected Community Primary Schools in Etche Local Government Area, Rivers State, Nigeria.","authors":"Rhoda Nwalozie, Mary Egbukele, Chinonye Oluchi Ezenwaka","doi":"10.53771/ijbpsa.2024.7.1.0026","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0026","url":null,"abstract":"Soil-transmitted helminths pose significant public health concerns, particularly among school-aged children in resource-constrained settings. This study aimed to investigate the prevalence of soil-transmitted helminths among school-aged pupils in three selected Community Public Primary Schools, Etche Local Government Area, Rivers State, Nigeria. A cross-sectional study was conducted, involving 150 school-aged pupils (1-14 years old) from three Community Primary Schools which included State School 1, State School 2, and Community Primary School, all in Etche. A structured questionnaire was administered to gather information on socio-demographic factors. Stool samples collected from each pupil were examined using the Kato-Katz technique and the STH parasites identified with keys. The overall prevalence of soil-transmitted helminth infection in the three selected schools in this study was 46%. Results obtained from this study according to sex showed that more males (52%) were infected than females (40%). Children between 5-7 years were the most infected in State School 2 and Community Primary School; while children between 12-14 years were the most infected in State School 1. Also, this study revealed that children in State School 2 had the highest soil-transmitted helminths infection (56%); while State School 1 recorded the least infection rate (34%). In this present study, Strongyloides stercoralis was the least prevalent soil-transmitted helminths while Ascaris lumbricoides (36) was the most occurring parasite in this study. There was no association (p>0.05) between age and gender and the prevalence of the parasite infection. A comprehensive control programme should be implemented in the area to curb the spread of infection.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0022
Sharon John, Ananda Lakshmy K N, Anjali Sivaram
Introduction : Maintaining health is influenced not only by the quantity and quality of food but also by the manner in which it is consumed. The processes of digestion, absorption, and assimilation involve intricate procedures influenced by physical, physiological, social, and emotional factors. To fully reap the benefits of food, adherence to specific guidelines is essential. Ayurveda provides insights into what, when, where, and how food should be consumed to optimize its effects on overall well-being. Aims and Objectives: To assess and compile information on diverse dietary and dining guidelines (Ahara Vidhi Vidhana) documented in Ayurvedic texts, examining their structure and effectiveness within the context of Charaka Samhita. Materials and Methods: The data for the review primarily collected from Ayurvedic Samhitas, including Charaka Samhita, Susrutha Samhita, Ashtanga Sangraha, Ashtanga Hridaya, and Sharangadhara Samhita. Observations: The guidelines are categorized into dietary rules and dining rules. The former outlines the types of food that should be consumed based on their quality and the individual's condition. The latter focuses on the manner in which food should be consumed, directly influencing both the hygiene of the food and the state of the mind. Conclusion: Both Ahara (diet) and Ahara Vidhi Vidhana (dietetic rules) are extremely significant in our day to day life . The appropriate application of both contributes to maintaining a healthy condition, while their improper utilization can lead to various diseases.
{"title":"The Art of Eating Right: Ahara Vidhi Vidhana in Ayurvedic Perspective","authors":"Sharon John, Ananda Lakshmy K N, Anjali Sivaram","doi":"10.53771/ijbpsa.2024.7.1.0022","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0022","url":null,"abstract":"Introduction : Maintaining health is influenced not only by the quantity and quality of food but also by the manner in which it is consumed. The processes of digestion, absorption, and assimilation involve intricate procedures influenced by physical, physiological, social, and emotional factors. To fully reap the benefits of food, adherence to specific guidelines is essential. Ayurveda provides insights into what, when, where, and how food should be consumed to optimize its effects on overall well-being. Aims and Objectives: To assess and compile information on diverse dietary and dining guidelines (Ahara Vidhi Vidhana) documented in Ayurvedic texts, examining their structure and effectiveness within the context of Charaka Samhita. Materials and Methods: The data for the review primarily collected from Ayurvedic Samhitas, including Charaka Samhita, Susrutha Samhita, Ashtanga Sangraha, Ashtanga Hridaya, and Sharangadhara Samhita. Observations: The guidelines are categorized into dietary rules and dining rules. The former outlines the types of food that should be consumed based on their quality and the individual's condition. The latter focuses on the manner in which food should be consumed, directly influencing both the hygiene of the food and the state of the mind. Conclusion: Both Ahara (diet) and Ahara Vidhi Vidhana (dietetic rules) are extremely significant in our day to day life . The appropriate application of both contributes to maintaining a healthy condition, while their improper utilization can lead to various diseases.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0029
E. Adeghe, Chioma Anthonia Okolo, Olumuyiwa Tolulope Ojeyinka
Early Childhood Caries (ECC) is a prevalent and preventable oral health concern among children, presenting unique challenges when managing those with autism and developmental disorders. This paper explores navigating ECC management in this population from a U.S. perspective. Understanding the impact of autism spectrum disorder (ASD) and developmental disorders on oral health is crucial, given their higher risk of ECC due to behavioral, dietary, and hygiene factors. Diagnosis and assessment pose particular challenges, requiring tailored approaches to accommodate sensory sensitivities and communication barriers. Preventive strategies encompass parent/caregiver education, customized oral hygiene instruction, dietary counseling, and fluoride varnish application. Behavioral management techniques, such as desensitization and creating a positive dental experience, are essential for successful treatment. Treatment approaches may involve restorative procedures, considering sedation or anesthesia for children with heightened anxiety or sensory issues, often requiring collaboration with multidisciplinary teams. Long-term management emphasizes maintaining oral health habits and regular dental visits, adjusting to changes in behavior and developmental needs over time. Addressing barriers to care, including access, financial constraints, and provider education, is crucial for effective ECC management in this population. ECC management in children with autism and developmental disorders requires a comprehensive, multidisciplinary approach tailored to individual needs. Future research should focus on refining diagnostic techniques, enhancing preventive interventions, and improving access to dental care services for this vulnerable population. By addressing these challenges, we can strive to improve oral health outcomes and quality of life for children with autism and developmental disorders.
{"title":"Navigating early childhood caries management in children with autism and developmental disorders: A U.S. perspective","authors":"E. Adeghe, Chioma Anthonia Okolo, Olumuyiwa Tolulope Ojeyinka","doi":"10.53771/ijbpsa.2024.7.1.0029","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0029","url":null,"abstract":"Early Childhood Caries (ECC) is a prevalent and preventable oral health concern among children, presenting unique challenges when managing those with autism and developmental disorders. This paper explores navigating ECC management in this population from a U.S. perspective. Understanding the impact of autism spectrum disorder (ASD) and developmental disorders on oral health is crucial, given their higher risk of ECC due to behavioral, dietary, and hygiene factors. Diagnosis and assessment pose particular challenges, requiring tailored approaches to accommodate sensory sensitivities and communication barriers. Preventive strategies encompass parent/caregiver education, customized oral hygiene instruction, dietary counseling, and fluoride varnish application. Behavioral management techniques, such as desensitization and creating a positive dental experience, are essential for successful treatment. Treatment approaches may involve restorative procedures, considering sedation or anesthesia for children with heightened anxiety or sensory issues, often requiring collaboration with multidisciplinary teams. Long-term management emphasizes maintaining oral health habits and regular dental visits, adjusting to changes in behavior and developmental needs over time. Addressing barriers to care, including access, financial constraints, and provider education, is crucial for effective ECC management in this population. ECC management in children with autism and developmental disorders requires a comprehensive, multidisciplinary approach tailored to individual needs. Future research should focus on refining diagnostic techniques, enhancing preventive interventions, and improving access to dental care services for this vulnerable population. By addressing these challenges, we can strive to improve oral health outcomes and quality of life for children with autism and developmental disorders.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"52 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.53771/ijbpsa.2024.7.1.0021
R. Othman, Ghofrane Sellami, Inchirah Karmous, Wahiba Douki, F. Mami, Olfa Berriche, K. Ben-Mahrez, F. B. Slama
Background: Obesity is a chronic disease associated with numerous complications, including metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Adipose tissue functions as an endocrine organ, producing hormones that play a crucial role in regulating metabolic homeostasis, such as ghrelin and resistin. Objective: The aim of this study was to compare the levels of resistin and ghrelin in obese men with metabolic syndrome and age-matched men without metabolic syndrome. Methods: Anthropometric measurements and biochemical assays were conducted to assess glycemia, resistin levels, insulin levels, and ghrelin levels. Results: The study comprised 58 obese men with metabolic syndrome and 53 age-matched control group men. In obese individuals, there was a significant increase in insulin and resistin levels, while ghrelin levels were notably decreased compared to the control group. Additionally, a positive correlation was observed between resistin levels and parameters such as BMI, waist circumference, and insulin levels. Conclusion: The findings from this study suggest that both resistin and ghrelin may serve as potential biomarkers for identifying metabolic syndrome in obese men.
{"title":"Assessment of ghrelin and resistin levels in a group of obese men with metabolic syndrome","authors":"R. Othman, Ghofrane Sellami, Inchirah Karmous, Wahiba Douki, F. Mami, Olfa Berriche, K. Ben-Mahrez, F. B. Slama","doi":"10.53771/ijbpsa.2024.7.1.0021","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0021","url":null,"abstract":"Background: Obesity is a chronic disease associated with numerous complications, including metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Adipose tissue functions as an endocrine organ, producing hormones that play a crucial role in regulating metabolic homeostasis, such as ghrelin and resistin. Objective: The aim of this study was to compare the levels of resistin and ghrelin in obese men with metabolic syndrome and age-matched men without metabolic syndrome. Methods: Anthropometric measurements and biochemical assays were conducted to assess glycemia, resistin levels, insulin levels, and ghrelin levels. Results: The study comprised 58 obese men with metabolic syndrome and 53 age-matched control group men. In obese individuals, there was a significant increase in insulin and resistin levels, while ghrelin levels were notably decreased compared to the control group. Additionally, a positive correlation was observed between resistin levels and parameters such as BMI, waist circumference, and insulin levels. Conclusion: The findings from this study suggest that both resistin and ghrelin may serve as potential biomarkers for identifying metabolic syndrome in obese men.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.53771/ijbpsa.2024.7.1.0017
Kogha Nicholas, Emuoghenerue Ekokidolor Onoriode, Ebereghwa Eguono, Anyanwu Ebiringa Blaise
Magnetic resonance imaging(MRI) is a veritable radiological diagnostic tool for the in-depth diagnosis of various ailment involving virtually all organ systems of the human body. The machinery for this radiological investigation tool is quite huge and needs installation in a spacious, well ventilated and air-conditioned room. It also must have verified working alternative power source as the essential lithium gas needed for its proper working must be kept cool at all times, and the environment where the MRI equipment is installed must always be kept at an ambient room temperature. This requirement means that a regular power supply must be assured as the lack of it may impact negatively on the functional ability of the equipment, which was procured at a great cost, its installation and maintenance also at a great deal of scarce fund. So, all care must be put in place not to endanger the perfect workings of the MRI equipment. Angry hospital workers deliberately shut off the electrical and water supply to the MRI unit in protest, aiming to force management to address their grievances. However, this action had severe consequences for the MRI machine, as its cooling system for the essential helium gas was disrupted, leading to gas depletion from the cannisters. This incident underscores the critical need for uninterrupted power and cooling systems in MRI installations to ensure their proper functioning and avoid costly damage.
{"title":"Overcoming Operational Challenges: A Case Study of MRI Functionality in Resource-Scarce Regions","authors":"Kogha Nicholas, Emuoghenerue Ekokidolor Onoriode, Ebereghwa Eguono, Anyanwu Ebiringa Blaise","doi":"10.53771/ijbpsa.2024.7.1.0017","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0017","url":null,"abstract":"Magnetic resonance imaging(MRI) is a veritable radiological diagnostic tool for the in-depth diagnosis of various ailment involving virtually all organ systems of the human body. The machinery for this radiological investigation tool is quite huge and needs installation in a spacious, well ventilated and air-conditioned room. It also must have verified working alternative power source as the essential lithium gas needed for its proper working must be kept cool at all times, and the environment where the MRI equipment is installed must always be kept at an ambient room temperature. This requirement means that a regular power supply must be assured as the lack of it may impact negatively on the functional ability of the equipment, which was procured at a great cost, its installation and maintenance also at a great deal of scarce fund. So, all care must be put in place not to endanger the perfect workings of the MRI equipment. Angry hospital workers deliberately shut off the electrical and water supply to the MRI unit in protest, aiming to force management to address their grievances. However, this action had severe consequences for the MRI machine, as its cooling system for the essential helium gas was disrupted, leading to gas depletion from the cannisters. This incident underscores the critical need for uninterrupted power and cooling systems in MRI installations to ensure their proper functioning and avoid costly damage.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"470 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.53771/ijbpsa.2024.7.1.0014
Mohammad Vicky Indra Pradicta, Widjiati Widjiati, Ratna Damayanti, Maslichah Mafruchati, Epy Muhammad Luqman
The aim of this research was to demonstrate lung histopathological damage in mice (Mus musculus) caused by carbofuran exposure. Twenty female mice (Mus musculus) aged 10 weeks with a body weight of 25-30 g were used in the study. The mice were divided into four groups: P0, P1, P2, and P3. All samples received 0.5 ml/day of physiological NaCl, and P1, P2, and P3 were additionally exposed to carbofuran at doses of 0.0208, 0.0417, and 0.0833 mg/kg body weight of mice/day, respectively. This treatment was carried out for 10 days. Data analysis was performed using ANOVA followed by the BNJ test. The results showed an increase in necrotic type II cells with increasing doses of carbofuran.
{"title":"The influence of carbofuran insecticide exposure on the number of type II Lung Cells in Mice (Mus musculus)","authors":"Mohammad Vicky Indra Pradicta, Widjiati Widjiati, Ratna Damayanti, Maslichah Mafruchati, Epy Muhammad Luqman","doi":"10.53771/ijbpsa.2024.7.1.0014","DOIUrl":"https://doi.org/10.53771/ijbpsa.2024.7.1.0014","url":null,"abstract":"The aim of this research was to demonstrate lung histopathological damage in mice (Mus musculus) caused by carbofuran exposure. Twenty female mice (Mus musculus) aged 10 weeks with a body weight of 25-30 g were used in the study. The mice were divided into four groups: P0, P1, P2, and P3. All samples received 0.5 ml/day of physiological NaCl, and P1, P2, and P3 were additionally exposed to carbofuran at doses of 0.0208, 0.0417, and 0.0833 mg/kg body weight of mice/day, respectively. This treatment was carried out for 10 days. Data analysis was performed using ANOVA followed by the BNJ test. The results showed an increase in necrotic type II cells with increasing doses of carbofuran.","PeriodicalId":400966,"journal":{"name":"International Journal of Biological and Pharmaceutical Sciences Archive","volume":"579 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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