Establishment of a bio-industry-need hemisection of spinal cord rat model

Abstract

Spinal cord injury (SCI) is a severe central nervous system disorder, and due to its complex pathophysiology, effective treatment strategies are currently lacking, posing a significant challenge in the field of medicine. While research into the fundamentals of SCI continues to advance and innovate, there exists a gap between basic research and clinical applications, hindering the translation of basic research findings into clinical practice. One of the reasons for this gap is the use of non-standardized animal models for SCI, which leads to inaccuracies in research results and reduces the guidance value of basic research for clinical treatment. This study provides a SCI rat model for R&D of SCI medicine target research and therapeutic strategy designs.